BACKGROUND AND STUDY AIMS: The correct histological diagnosis of gastric borderline adenomas is often difficult, especially in excluding malignancy, since the usual diagnostic methods, such as radiography and histological examination of forceps biopsy specimens, are of limited accuracy. The aim of this study was to retrospectively analyze the value of endoscopic mucosal resection in establishing the correct diagnosis of borderline adenomas. RESULTS: Fourteen borderline adenomas were finally diagnosed as containing early gastric cancer type IIa (well-differentiated tubular adenocarcinoma) after endoscopic mucosal resection, of the remaining 36 tubular adenomas, six represented mild dysplasia, 24 moderate dysplasia, and six severe dysplasia. Most parts of the 14 adenomas containing early gastric cancers had regions of structural atypia, and cellular atypia was moderate in all. Seven of 14 cancers were completely resected, all patients being tumor-free after a follow-up of 33-61 months. CONCLUSIONS: These results suggest that diagnosing borderline adenoma on the basis of radiographic and endoscopic-bioptic findings is generally unreliable, because biopsy specimens may not be representative of the entire lesion. Borderline adenomas of the stomach should be completely resected by endoscopic mucosal resection to obtain a final diagnosis and - depending on the size and type of the lesion - possibly also definitive treatment.
BACKGROUND AND STUDY AIMS: The correct histological diagnosis of gastric borderline adenomas is often difficult, especially in excluding malignancy, since the usual diagnostic methods, such as radiography and histological examination of forceps biopsy specimens, are of limited accuracy. The aim of this study was to retrospectively analyze the value of endoscopic mucosal resection in establishing the correct diagnosis of borderline adenomas. RESULTS: Fourteen borderline adenomas were finally diagnosed as containing early gastric cancer type IIa (well-differentiated tubular adenocarcinoma) after endoscopic mucosal resection, of the remaining 36 tubular adenomas, six represented mild dysplasia, 24 moderate dysplasia, and six severe dysplasia. Most parts of the 14 adenomas containing early gastric cancers had regions of structural atypia, and cellular atypia was moderate in all. Seven of 14 cancers were completely resected, all patients being tumor-free after a follow-up of 33-61 months. CONCLUSIONS: These results suggest that diagnosing borderline adenoma on the basis of radiographic and endoscopic-bioptic findings is generally unreliable, because biopsy specimens may not be representative of the entire lesion. Borderline adenomas of the stomach should be completely resected by endoscopic mucosal resection to obtain a final diagnosis and - depending on the size and type of the lesion - possibly also definitive treatment.
Authors: Won Jae Yoon; Dong Ho Lee; Yong Jin Jung; Ji Bong Jeong; Ji Won Kim; Byeong Gwan Kim; Kook Lae Lee; Kwang Hyuck Lee; Young Soo Park; Jin-Hyeok Hwang; Jin-Wook Kim; Nayoung Kim; Jun Kyu Lee; Hyun Chae Jung; Yong Bum Yoon; In Sung Song Journal: World J Gastroenterol Date: 2006-07-07 Impact factor: 5.742
Authors: Henry Córdova; Lidia Argüello; Carme Loras; Antonio Naranjo Rodríguez; Faust Riu Pons; Joan B Gornals; David Nicolás-Pérez; Xavier Andújar Murcia; Luis Hernández; Santos Santolaria; Carles Leal; Carles Pons; Enrique Pérez-Cuadrado-Robles; Orlando García-Bosch; Michel Papo Berger; José Luis Ulla Rocha; Cristina Sánchez-Montes; Gloria Fernández-Esparrach Journal: World J Gastroenterol Date: 2017-12-21 Impact factor: 5.742
Authors: Tae Young Park; Su Jin Jeong; Tae Hyung Kim; Jin Lee; Jongha Park; Tae Oh Kim; Yong Eun Park Journal: Medicine (Baltimore) Date: 2020-03 Impact factor: 1.817