Literature DB >> 8854864

A radiation hybrid map spanning the entire human X chromosome integrating YACs, genes, and STS markers.

J Kumlien1, A Grigoriev, H Roest Crollius, M Ross, P N Goodfellow, H Lehrach.   

Abstract

We present a radiation hybrid (RH) map of human Chromosome (Chr) X, using 50 markers on 72 radiation hybrids. The markers, obtained from the consensus map, form a grid spanning the entire chromosome. To check the RH map, the marker order was determined by analysis of presence or absence of retained human DNA fragments in the RHs; the comparison with the consensus showed a similar order. Any STSs, microsatellites, genes, and clones can be positioned and ordered relative to the marker grid. This approach integrates genetic, physical, and large-scale clone mapping and is used to link YAC contigs containing data from various experimental sources.

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Year:  1996        PMID： 8854864     DOI： 10.1007/s003359900227

Source DB:  PubMed          Journal:  Mamm Genome        ISSN： 0938-8990            Impact factor:   2.957


  23 in total

1.  Radiation fusion hybrids for human chromosomes 3 and X generated at various irradiation doses.

Authors:  T S Sidén; J Kumlien; C E Schwartz; D Röhme
Journal:  Somat Cell Mol Genet       Date:  1992-01

2.  Mapping irradiation hybrids to cosmid and yeast artificial chromosome libraries by direct hybridization of Alu-PCR products.

Authors:  A P Monaco; V M Lam; G Zehetner; G G Lennon; C Douglas; D Nizetic; P N Goodfellow; H Lehrach
Journal:  Nucleic Acids Res       Date:  1991-06-25       Impact factor: 16.971

3.  A theory for radiation hybrid (Goss-Harris) mapping: application to proximal 21q markers.

Authors:  A Chakravarti; J E Reefer
Journal:  Cytogenet Cell Genet       Date:  1992

4.  Statistical methods for multipoint radiation hybrid mapping.

Authors:  M Boehnke; K Lange; D R Cox
Journal:  Am J Hum Genet       Date:  1991-12       Impact factor: 11.025

5.  Rapid construction of integrated maps using inner product mapping: YAC coverage of human chromosome 11.

Authors:  M W Perlin; D J Duggan; K Davis; J E Farr; R B Findler; M J Higgins; N J Nowak; G A Evans; S Qin; J Zhang
Journal:  Genomics       Date:  1995-07-20       Impact factor: 5.736

Review 6.  Radiation hybrids: irradiation and fusion gene transfer.

Authors:  M A Walter; P N Goodfellow
Journal:  Trends Genet       Date:  1993-10       Impact factor: 11.639

7.  Criterion for the completeness of large-scale physical maps of DNA.

Authors:  M V Olson; P Green
Journal:  Cold Spring Harb Symp Quant Biol       Date:  1993

8.  Generation of novel sequence tagged sites (STSs) from discrete chromosomal regions using Alu-PCR.

Authors:  C G Cole; P N Goodfellow; M Bobrow; D R Bentley
Journal:  Genomics       Date:  1991-07       Impact factor: 5.736

9.  A radiation hybrid map of human chromosome 18.

Authors:  U Francke; E Chang; K Comeau; E M Geigl; J Giacalone; X Li; J Luna; A Moon; S Welch; P Wilgenbus
Journal:  Cytogenet Cell Genet       Date:  1994

10.  A radiation hybrid map of the region on human chromosome 22 containing the neurofibromatosis type 2 locus.

Authors:  K A Frazer; M Boehnke; M L Budarf; R K Wolff; B S Emanuel; R M Myers; D R Cox
Journal:  Genomics       Date:  1992-11       Impact factor: 5.736
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  1 in total

1.  Interspersed repetitive sequence (IRS)-PCR for typing of whole genome radiation hybrid panels.

Authors:  H Himmelbauer; L C Schalkwyk; H Lehrach
Journal:  Nucleic Acids Res       Date:  2000-01-15       Impact factor: 16.971
  1 in total

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