Literature DB >> 8849229

Differential regulation of the mcb and emr operons of Escherichia coli: role of mcb in multidrug resistance.

O Lomovskaya1, F Kawai, A Matin.   

Abstract

The mcb operon (which is responsible for microcin B17 production) and the emr operon (which encodes a multidrug resistance pump) share a common negative regulator, EmrR. Nevertheless, compounds that induce the emr operon repress the mcb operon. The pump dedicated to microcin B17 extrusion can also protect the calls against sparfloxacin and other toxic compounds.

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Year:  1996        PMID： 8849229      PMCID： PMC163261     

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  14 in total

Review 1.  Genetics of ribosomally synthesized peptide antibiotics.

Authors:  R Kolter; F Moreno
Journal:  Annu Rev Microbiol       Date:  1992       Impact factor: 15.500

2.  Nucleotide sequence of the Escherichia coli regulatory gene mprA and construction and characterization of mprA-deficient mutants.

Authors:  I del Castillo; J E González-Pastor; J L San Millán; F Moreno
Journal:  J Bacteriol       Date:  1991-06       Impact factor: 3.490

3.  Stationary-phase-inducible "gearbox" promoters: differential effects of katF mutations and role of sigma 70.

Authors:  D E Bohannon; N Connell; J Keener; A Tormo; M Espinosa-Urgel; M M Zambrano; R Kolter
Journal:  J Bacteriol       Date:  1991-07       Impact factor: 3.490

4.  Growth phase and ompR regulation of transcription of microcin B17 genes.

Authors:  C Hernández-Chico; J L San Millán; R Kolter; F Moreno
Journal:  J Bacteriol       Date:  1986-09       Impact factor: 3.490

5.  Improved single and multicopy lac-based cloning vectors for protein and operon fusions.

Authors:  R W Simons; F Houman; N Kleckner
Journal:  Gene       Date:  1987       Impact factor: 3.688

6.  Nucleotide sequence and characterization of the Staphylococcus aureus norA gene, which confers resistance to quinolones.

Authors:  H Yoshida; M Bogaki; S Nakamura; K Ubukata; M Konno
Journal:  J Bacteriol       Date:  1990-12       Impact factor: 3.490

7.  Posttranslational modifications in microcin B17 define an additional class of DNA gyrase inhibitor.

Authors:  P Yorgey; J Lee; J Kördel; E Vivas; P Warner; D Jebaratnam; R Kolter
Journal:  Proc Natl Acad Sci U S A       Date:  1994-05-10       Impact factor: 11.205

8.  Emr, an Escherichia coli locus for multidrug resistance.

Authors:  O Lomovskaya; K Lewis
Journal:  Proc Natl Acad Sci U S A       Date:  1992-10-01       Impact factor: 11.205

9.  EmrR is a negative regulator of the Escherichia coli multidrug resistance pump EmrAB.

Authors:  O Lomovskaya; K Lewis; A Matin
Journal:  J Bacteriol       Date:  1995-05       Impact factor: 3.490

10.  Plasmid genes required for microcin B17 production.

Authors:  J L San Millán; R Kolter; F Moreno
Journal:  J Bacteriol       Date:  1985-09       Impact factor: 3.490
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  13 in total

1.  Purification and ligand binding of EmrR, a regulator of a multidrug transporter.

Authors:  A Brooun; J J Tomashek; K Lewis
Journal:  J Bacteriol       Date:  1999-08       Impact factor: 3.490

2.  The EmrR protein represses the Escherichia coli emrRAB multidrug resistance operon by directly binding to its promoter region.

Authors:  A Xiong; A Gottman; C Park; M Baetens; S Pandza; A Matin
Journal:  Antimicrob Agents Chemother       Date:  2000-10       Impact factor: 5.191

Review 3.  Linkage map of Escherichia coli K-12, edition 10: the traditional map.

Authors:  M K Berlyn
Journal:  Microbiol Mol Biol Rev       Date:  1998-09       Impact factor: 11.056

Review 4.  Adaptive and mutational resistance: role of porins and efflux pumps in drug resistance.

Authors:  Lucía Fernández; Robert E W Hancock
Journal:  Clin Microbiol Rev       Date:  2012-10       Impact factor: 26.132

Review 5.  Regulation of bacterial drug export systems.

Authors:  Steve Grkovic; Melissa H Brown; Ronald A Skurray
Journal:  Microbiol Mol Biol Rev       Date:  2002-12       Impact factor: 11.056

6.  Mechanism of plasmid-mediated quinolone resistance.

Authors:  John H Tran; George A Jacoby
Journal:  Proc Natl Acad Sci U S A       Date:  2002-04-09       Impact factor: 11.205

7.  Intrinsic resistance of Mycobacterium smegmatis to fluoroquinolones may be influenced by new pentapeptide protein MfpA.

Authors:  C Montero; G Mateu; R Rodriguez; H Takiff
Journal:  Antimicrob Agents Chemother       Date:  2001-12       Impact factor: 5.191

8.  Prevalence of plasmid-mediated quinolone resistance.

Authors:  George A Jacoby; Nancy Chow; Ken B Waites
Journal:  Antimicrob Agents Chemother       Date:  2003-02       Impact factor: 5.191

Review 9.  Efflux-mediated drug resistance in bacteria.

Authors:  Xian-Zhi Li; Hiroshi Nikaido
Journal:  Drugs       Date:  2004       Impact factor: 9.546

Review 10.  Exploiting bacterial DNA gyrase as a drug target: current state and perspectives.

Authors:  Frédéric Collin; Shantanu Karkare; Anthony Maxwell
Journal:  Appl Microbiol Biotechnol       Date:  2011-09-09       Impact factor: 4.813
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