Literature DB >> 10991887

The EmrR protein represses the Escherichia coli emrRAB multidrug resistance operon by directly binding to its promoter region.

A Xiong1, A Gottman, C Park, M Baetens, S Pandza, A Matin.   

Abstract

EmrR negatively regulates the transcription of the multidrug resistance pump-encoding operon, emrRAB, by binding to its regulatory region. The binding site spans the promoter and the downstream sequence up to the transcriptional start site of the operon. Structurally unrelated drugs that induce the pump interfere with this binding.

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Year:  2000        PMID： 10991887      PMCID： PMC90178          DOI： 10.1128/AAC.44.10.2905-2907.2000

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  12 in total

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Authors:  A Brooun; J J Tomashek; K Lewis
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Review 2.  Proton-dependent multidrug efflux systems.

Authors:  I T Paulsen; M H Brown; R A Skurray
Journal:  Microbiol Rev       Date:  1996-12

3.  Improved M13 phage cloning vectors and host strains: nucleotide sequences of the M13mp18 and pUC19 vectors.

Authors:  C Yanisch-Perron; J Vieira; J Messing
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4.  Structural basis of multidrug recognition by BmrR, a transcription activator of a multidrug transporter.

Authors:  E E Zheleznova; P N Markham; A A Neyfakh; R G Brennan
Journal:  Cell       Date:  1999-02-05       Impact factor: 41.582

Review 5.  Major facilitator superfamily.

Authors:  S S Pao; I T Paulsen; M H Saier
Journal:  Microbiol Mol Biol Rev       Date:  1998-03       Impact factor: 11.056

6.  A protein that activates expression of a multidrug efflux transporter upon binding the transporter substrates.

Authors:  M Ahmed; C M Borsch; S S Taylor; N Vázquez-Laslop; A A Neyfakh
Journal:  J Biol Chem       Date:  1994-11-11       Impact factor: 5.157

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Authors:  O Lomovskaya; K Lewis
Journal:  Proc Natl Acad Sci U S A       Date:  1992-10-01       Impact factor: 11.205

8.  EmrR is a negative regulator of the Escherichia coli multidrug resistance pump EmrAB.

Authors:  O Lomovskaya; K Lewis; A Matin
Journal:  J Bacteriol       Date:  1995-05       Impact factor: 3.490

9.  Binding of purified multiple antibiotic-resistance repressor protein (MarR) to mar operator sequences.

Authors:  R G Martin; J L Rosner
Journal:  Proc Natl Acad Sci U S A       Date:  1995-06-06       Impact factor: 11.205

10.  QacR is a repressor protein that regulates expression of the Staphylococcus aureus multidrug efflux pump QacA.

Authors:  S Grkovic; M H Brown; N J Roberts; I T Paulsen; R A Skurray
Journal:  J Biol Chem       Date:  1998-07-17       Impact factor: 5.157
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  26 in total

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5.  The dimeric form of the unphosphorylated response regulator BaeR.

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6.  Amino acid residues involved in inactivation of the Escherichia coli multidrug resistance repressor MarR by salicylate, 2,4-dinitrophenol, and plumbagin.

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7.  MarA, SoxS and Rob of Escherichia coli - Global regulators of multidrug resistance, virulence and stress response.

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9.  Characterization of NorR protein, a multifunctional regulator of norA expression in Staphylococcus aureus.

Authors:  Que Chi Truong-Bolduc; Xiamei Zhang; David C Hooper
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10.  Structural and biochemical characterization of MepR, a multidrug binding transcription regulator of the Staphylococcus aureus multidrug efflux pump MepA.

Authors:  Muthiah Kumaraswami; Jason T Schuman; Susan M Seo; Glenn W Kaatz; Richard G Brennan
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