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Literature DB >> 8826856

Confocal microscopy of idarubicin localisation in sensitive and multidrug-resistant bladder cancer cell lines.

P M Duffy¹, M C Hayes, A Cooper, C J Smart.

Abstract

Idarubicin is a highly lipophilic anthracycline and appears effective against tumours resistant to conventional anthracyclines. Confocal microscopy demonstrates predominantly cytoplasmic idarubicin accumulation. This distribution is unaltered by resistance status or the resistance reversing agent verapamil. Our results contrast with studies on conventional anthracyclines and suggest that nuclear accumulation may not be a prerequisite for anthracycline cytotoxicity.

Entities: Chemical Disease

Mesh：

Substances：

Year: 1996 PMID： 8826856 PMCID： PMC2074719 DOI： 10.1038/bjc.1996.455

Source DB: PubMed Journal: Br J Cancer ISSN： 0007-0920 Impact factor: 7.640

12 in total

1. Analysis of the steady-state and initial rate of doxorubicin efflux from a series of multidrug-resistant cells expressing different levels of P-glycoprotein.

Authors: P D Roepe
Journal: Biochemistry Date: 1992-12-22 Impact factor: 3.162

2. Comparative cellular pharmacology of daunorubicin and idarubicin in human multidrug-resistant leukemia cells.

Authors: E Berman; M McBride
Journal: Blood Date: 1992-06-15 Impact factor: 22.113

3. Subcellular distribution of daunorubicin in P-glycoprotein-positive and -negative drug-resistant cell lines using laser-assisted confocal microscopy.

Authors: J E Gervasoni; S Z Fields; S Krishna; M A Baker; M Rosado; K Thuraisamy; A A Hindenburg; R N Taub
Journal: Cancer Res Date: 1991-09-15 Impact factor: 12.701

4. The human multidrug resistance-associated protein MRP is a plasma membrane drug-efflux pump.

Authors: G J Zaman; M J Flens; M R van Leusden; M de Haas; H S Mülder; J Lankelma; H M Pinedo; R J Scheper; F Baas; H J Broxterman
Journal: Proc Natl Acad Sci U S A Date: 1994-09-13 Impact factor: 11.205

Review 5. Multidrug resistance.

Authors: J A Moscow; E Schneider; K H Cowan
Journal: Cancer Chemother Biol Response Modif Date: 1993

6. Multi-drug resistance of a doxorubicin-resistant bladder cancer cell line.

Authors: J W Floyd; C W Lin; G R Prout
Journal: J Urol Date: 1990-07 Impact factor: 7.450

7. Determination and reversal of resistance to epirubicin intravesical chemotherapy. A confocal imaging study.

Authors: P M Duffy; M C Hayes; S K Gatrell; A Cooper; C J Smart
Journal: Br J Urol Date: 1996-06

Review 8. Epirubicin. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic use in cancer chemotherapy.

Authors: G L Plosker; D Faulds
Journal: Drugs Date: 1993-05 Impact factor: 9.546

9. Cellular daunomycin fluorescence in multidrug resistant 2780AD cells and its relation to cellular drug localisation.

Authors: J Lankelma; H S Mülder; F van Mourik; H W Wong Fong Sang; R Kraayenhof; R van Grondelle
Journal: Biochim Biophys Acta Date: 1991-07-10

10. Examination by laser scanning confocal fluorescence imaging microscopy of the subcellular localisation of anthracyclines in parent and multidrug resistant cell lines.

Authors: H M Coley; W B Amos; P R Twentyman; P Workman
Journal: Br J Cancer Date: 1993-06 Impact factor: 7.640

3 in total