Literature DB >> 12543697

Growth-inhibitory effects of artesunate, pyrimethamine, and pamaquine against Babesia equi and Babesia caballi in in vitro cultures.

Akiko Nagai1, Naoaki Yokoyama, Tomohide Matsuo, Sabine Bork, Haruyuki Hirata, Xuenan Xuan, Yinchang Zhu, Florencia G Claveria, Kozo Fujisaki, Ikuo Igarashi.   

Abstract

Three antimalarial drugs, artesunate, pyrimethamine, and pamaquine, were evaluated for their growth-inhibitory effects against Babesia equi and Babesia caballi in in vitro culture. B. equi was more resistant to pyrimethamine than B. caballi. B. equi was also found to be more sensitive to artesunate and pamaquine than B. caballi. Of the three compounds, pyrimethamine gave the most promise for in vivo effectiveness.

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Year:  2003        PMID： 12543697      PMCID： PMC151728          DOI： 10.1128/AAC.47.2.800-803.2003

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  19 in total

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Authors:  I Igarashi; F K Njonge; Y Kaneko; Y Nakamura
Journal:  Exp Parasitol       Date:  1998-11       Impact factor: 2.011

2.  Ultrastructural characteristics of Babesia caballi in equine erythrocytes in vitro.

Authors:  S Kawai; I Igarashi; A Abgaandorjiin; K Miyazawa; H Ikadai; H Nagasawa; K Fujisaki; T Mikami; N Suzuki; H Matsuda
Journal:  Parasitol Res       Date:  1999-10       Impact factor: 2.289

3.  In vitro generation of novel pyrimethamine resistance mutations in the Toxoplasma gondii dihydrofolate reductase.

Authors:  M G Reynolds; J Oh; D S Roos
Journal:  Antimicrob Agents Chemother       Date:  2001-04       Impact factor: 5.191

4.  Plasmodium falciparum antimalarial drug susceptibility on the north-western border of Thailand during five years of extensive use of artesunate-mefloquine.

Authors:  A Brockman; R N Price; M van Vugt; D G Heppner; D Walsh; P Sookto; T Wimonwattrawatee; S Looareesuwan; N J White; F Nosten
Journal:  Trans R Soc Trop Med Hyg       Date:  2000 Sep-Oct       Impact factor: 2.184

5.  Transformation with human dihydrofolate reductase renders malaria parasites insensitive to WR99210 but does not affect the intrinsic activity of proguanil.

Authors:  D A Fidock; T E Wellems
Journal:  Proc Natl Acad Sci U S A       Date:  1997-09-30       Impact factor: 11.205

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Authors:  A W van Weert; H J Geuze; B Groothuis; W Stoorvogel
Journal:  Eur J Cell Biol       Date:  2000-06       Impact factor: 4.492

7.  The effects of quinine and artesunate treatment on plasma tumor necrosis factor levels in malaria-infected patients.

Authors:  W Ittarat; R Udomsangpetch; K T Chotivanich; S Looareesuwan
Journal:  Southeast Asian J Trop Med Public Health       Date:  1999-03       Impact factor: 0.267

8.  8-Aminoquinolines active against blood stage Plasmodium falciparum in vitro inhibit hematin polymerization.

Authors:  J L Vennerstrom; E O Nuzum; R E Miller; A Dorn; L Gerena; P A Dande; W Y Ellis; R G Ridley; W K Milhous
Journal:  Antimicrob Agents Chemother       Date:  1999-03       Impact factor: 5.191

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Review 10.  Equine piroplasmosis an update on diagnosis, treatment and prevention.

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  13 in total

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Journal:  Parasitol Res       Date:  2013-10-31       Impact factor: 2.289

2.  Inhibitory effects of pepstatin A and mefloquine on the growth of Babesia parasites.

Authors:  Tserendorj Munkhjargal; Mahmoud AbouLaila; Mohamad Alaa Terkawi; Thillaiampalam Sivakumar; Madoka Ichikawa; Batdorj Davaasuren; Tserendorj Nyamjargal; Naoaki Yokoyama; Ikuo Igarashi
Journal:  Am J Trop Med Hyg       Date:  2012-08-13       Impact factor: 2.345

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4.  Inhibitory effect of cyclophilin A from the hard tick Haemaphysalis longicornis on the growth of Babesia bovis and Babesia bigemina.

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Journal:  Parasitol Res       Date:  2013-03-27       Impact factor: 2.289

5.  Cloning, expression, and characterization of Babesia gibsoni dihydrofolate reductase-thymidylate synthase: inhibitory effect of antifolates on its catalytic activity and parasite proliferation.

Authors:  Gabriel O Aboge; Honglin Jia; Mohamad A Terkawi; Youn-Kyoung Goo; Yoshifumi Nishikawa; Fujiko Sunaga; Kuzuhiko Namikawa; Naotoshi Tsuji; Ikuo Igarashi; Hiroshi Suzuki; Kozo Fujisaki; Xuenan Xuan
Journal:  Antimicrob Agents Chemother       Date:  2008-09-15       Impact factor: 5.191

6.  Growth-inhibitory effect of heparin on Babesia parasites.

Authors:  Sabine Bork; Naoaki Yokoyama; Yuzuru Ikehara; Sanjay Kumar; Chihiro Sugimoto; Ikuo Igarashi
Journal:  Antimicrob Agents Chemother       Date:  2004-01       Impact factor: 5.191

Review 7.  Current advances in detection and treatment of babesiosis.

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Journal:  Curr Med Chem       Date:  2012       Impact factor: 4.530

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9.  Comparative genomic analysis and phylogenetic position of Theileria equi.

Authors:  Lowell S Kappmeyer; Mathangi Thiagarajan; David R Herndon; Joshua D Ramsay; Elisabet Caler; Appolinaire Djikeng; Joseph J Gillespie; Audrey Ot Lau; Eric H Roalson; Joana C Silva; Marta G Silva; Carlos E Suarez; Massaro W Ueti; Vishvanath M Nene; Robert H Mealey; Donald P Knowles; Kelly A Brayton
Journal:  BMC Genomics       Date:  2012-11-09       Impact factor: 3.969

10.  Activities of artesunate-based combinations and tafenoquine against Babesia bovis in vitro and Babesia microti in vivo.

Authors:  Leonardo J M Carvalho; Bunduurem Tuvshintulga; Arifin B Nugraha; Thillaiampalam Sivakumar; Naoaki Yokoyama
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