Literature DB >> 11353644

In vitro activities of DU-1102, a new trioxaquine derivative, against Plasmodium falciparum isolates.

L K Basco1, O Dechy-Cabaret, M Ndounga, F S Meche, A Robert, B Meunier.   

Abstract

The antimalarial trioxaquine derivative DU-1102, synthesized by covalent linkage between aminoquinoline and trioxane moieties, was highly active against Cameroonian isolates (mean 50% inhibitory concentration of 43 nmol/liter) of Plasmodium falciparum. There was no correlation between the responses to DU-1102 and chloroquine and only a low correlation between the responses to DU-1102 and pyrimethamine, suggesting an independent mode of action of the trioxaquine against the parasites.

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Year:  2001        PMID： 11353644      PMCID： PMC90564          DOI： 10.1128/AAC.45.6.1886-1888.2001

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  13 in total

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6.  In vitro activity of lumefantrine (benflumetol) against clinical isolates of Plasmodium falciparum in Yaoundé, Cameroon.

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Journal:  Antimicrob Agents Chemother       Date:  1998-09       Impact factor: 5.191

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Journal:  Microbiol Rev       Date:  1996-06

8.  Structure-activity relationships of the antimalarial agent artemisinin. 1. Synthesis and comparative molecular field analysis of C-9 analogs of artemisinin and 10-deoxoartemisinin.

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Journal:  J Med Chem       Date:  1993-12-24       Impact factor: 7.446

9.  Adaptations of the Saker-Solomons test: simple, reliable colorimetric field assays for chloroquine and its metabolites in urine.

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Journal:  Bull World Health Organ       Date:  1989       Impact factor: 9.408

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Authors:  P Ringwald; J Bickii; L Basco
Journal:  Lancet       Date:  1996-01-06       Impact factor: 79.321
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  9 in total

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Journal:  Antimicrob Agents Chemother       Date:  2005-03       Impact factor: 5.191

Review 2.  Are Antimalarial Hybrid Molecules a Close Reality or a Distant Dream?

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3.  Trioxaquines are new antimalarial agents active on all erythrocytic forms, including gametocytes.

Authors:  Françoise Benoit-Vical; Joël Lelièvre; Antoine Berry; Caroline Deymier; Odile Dechy-Cabaret; Jérôme Cazelles; Christophe Loup; Anne Robert; Jean-François Magnaval; Bernard Meunier
Journal:  Antimicrob Agents Chemother       Date:  2007-01-22       Impact factor: 5.191

4.  Synthesis, Structure-Activity Relationship, and Antimalarial Efficacy of 6-Chloro-2-arylvinylquinolines.

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Journal:  J Med Chem       Date:  2020-10-06       Impact factor: 7.446

5.  Next-Generation Antimalarial Drugs: Hybrid Molecules as a New Strategy in Drug Design.

Authors:  Francis W Muregi; Akira Ishih
Journal:  Drug Dev Res       Date:  2010-02       Impact factor: 4.360

6.  1-Bromo-2-(10β-dihydro-artemisin-oxy)ethane.

Authors:  Marli C Lombard; Manuel A Fernandes; Jaco C Breytenbach; David D N'da
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2010-07-31

7.  Anti-malarial effect of novel chloroquine derivatives as agents for the treatment of malaria.

Authors:  Seon-Ju Yeo; Dong-Xu Liu; Hak Sung Kim; Hyun Park
Journal:  Malar J       Date:  2017-02-17       Impact factor: 2.979

Review 8.  Endoperoxide antimalarials: development, structural diversity and pharmacodynamic aspects with reference to 1,2,4-trioxane-based structural scaffold.

Authors:  Mithun Rudrapal; Dipak Chetia
Journal:  Drug Des Devel Ther       Date:  2016-11-01       Impact factor: 4.162

9.  Artemisinin-(Iso)quinoline Hybrids by C-H Activation and Click Chemistry: Combating Multidrug-Resistant Malaria.

Authors:  Aysun Çapcı; Mélanie M Lorion; Hui Wang; Nina Simon; Maria Leidenberger; Mariana C Borges Silva; Diogo R M Moreira; Yongping Zhu; Yuqing Meng; Jia Yun Chen; Yew Mun Lee; Oliver Friedrich; Barbara Kappes; Jigang Wang; Lutz Ackermann; Svetlana B Tsogoeva
Journal:  Angew Chem Int Ed Engl       Date:  2019-08-08       Impact factor: 15.336
  9 in total

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