BACKGROUND: Myocardial contractile dysfunction has been frequently observed in adolescents or adults with cyanotic congenital heart disease. Impaired energy metabolism may be present in such dysfunctional myocardium. METHODS AND RESULTS: To evaluate the findings of myocardial free fatty acid metabolism, and its relations to ventricular wall motion and myocardial perfusion in cyanotic congenital heart disease, we performed a combined study of iodine 123-labeled 15-(p-iodophenyl)-3-(R,S)-methylpentadecanoic acid (BMIPP) scintigraphy, thallium scintigraphy, and contrast cine-angiography in seven patients with single right or left ventricle. The results showed that wall motion was reduced in 17 of 35 ventricular segments (49%), which were mostly identical in location to decreased BMIPP uptake. The severity of BMIPP uptake deficit correlated positively with the degree of impairment of wall motion. On the other hand, thallium uptake was abnormal only in 5 of 35 segments (14%), and the severity of the perfusion defect did not correlate with the degree of wall motion abnormality. CONCLUSIONS: Contractile dysfunction in cyanotic heart disease was primarily linked to impaired free fatty acid metabolism rather than to myocardial scar as represented by perfusion defect on thallium imaging.
BACKGROUND:Myocardial contractile dysfunction has been frequently observed in adolescents or adults with cyanotic congenital heart disease. Impaired energy metabolism may be present in such dysfunctional myocardium. METHODS AND RESULTS: To evaluate the findings of myocardial free fatty acid metabolism, and its relations to ventricular wall motion and myocardial perfusion in cyanotic congenital heart disease, we performed a combined study of iodine 123-labeled 15-(p-iodophenyl)-3-(R,S)-methylpentadecanoic acid (BMIPP) scintigraphy, thallium scintigraphy, and contrast cine-angiography in seven patients with single right or left ventricle. The results showed that wall motion was reduced in 17 of 35 ventricular segments (49%), which were mostly identical in location to decreased BMIPP uptake. The severity of BMIPP uptake deficit correlated positively with the degree of impairment of wall motion. On the other hand, thallium uptake was abnormal only in 5 of 35 segments (14%), and the severity of the perfusion defect did not correlate with the degree of wall motion abnormality. CONCLUSIONS:Contractile dysfunction in cyanotic heart disease was primarily linked to impaired free fatty acid metabolism rather than to myocardial scar as represented by perfusion defect on thallium imaging.
Authors: Y Fujibayashi; Y Yonekura; Y Takemura; K Wada; K Matsumoto; N Tamaki; K Yamamoto; J Konishi; A Yokoyama Journal: J Nucl Med Date: 1990-11 Impact factor: 10.057
Authors: N Tamaki; M Kawamoto; Y Yonekura; Y Fujibayashi; N Takahashi; J Konishi; R Nohara; H Kambara; C Kawai; K Ikekubo Journal: J Nucl Med Date: 1992-05 Impact factor: 10.057
Authors: M Kawamoto; N Tamaki; Y Yonekura; E Tadamura; Y Fujibayashi; Y Magata; R Nohara; S Sasayama; K Ikekubo; H Kato Journal: Ann Nucl Med Date: 1994-02 Impact factor: 2.668
Authors: C Kurata; K Tawarahara; T Taguchi; S Aoshima; A Kobayashi; N Yamazaki; H Kawai; M Kaneko Journal: J Nucl Med Date: 1992-01 Impact factor: 10.057
Authors: K Yamamoto; P Som; A B Brill; Y Yonekura; S C Srivastava; G E Meinken; J Iwai; M M Goodman; F F Knapp; D R Elmaleh Journal: J Nucl Med Date: 1986-07 Impact factor: 10.057