Literature DB >> 3723193

Dual tracer autoradiographic study of beta-methyl-(1-14C) heptadecanoic acid and 15-p-(131I)-iodophenyl-beta-methylpentadecanoic acid in normotensive and hypertensive rats.

K Yamamoto, P Som, A B Brill, Y Yonekura, S C Srivastava, G E Meinken, J Iwai, M M Goodman, F F Knapp, D R Elmaleh.   

Abstract

The myocardial distribution of 15-p-[131I]iodophenyl-3-(R,S)-methylpentadecanoic acid (BMPDA) and 1[14C]-3-(R,S)-methylheptadecanoic acid (BMHDA) was compared in normotensive and hypertensive rats using quantitative dual tracer autoradiographic techniques. The myocardial distribution of carbon-14 [14C] BMHDA and iodine-131 [131I] BMPDA was nearly homogeneous in the normotensive rats, while both tracers showed similar, though very heterogeneous, distribution in hypertensive hearts with decreased uptake in the endocardial region. Our data demonstrate that myocardial distribution of [131I]BMPDA was essentially the same as [14C]BMHDA, and thus single photon emission computed tomographic imaging with 123I-labeled BMPDA could be useful for the detection of regional changes of myocardial fatty acid uptake in patients with prolonged and severe hypertension.

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Year:  1986        PMID： 3723193

Source DB:  PubMed          Journal:  J Nucl Med        ISSN： 0161-5505            Impact factor:   10.057


  19 in total

Review 1.  BMIPP-design and development.

Authors:  F F Knapp; J Kropp
Journal:  Int J Card Imaging       Date:  1999-02

Review 2.  BMIPP compared with thallium redistribution.

Authors:  J Taki; I Matsunari; K Nakajima; N Tonami
Journal:  Int J Card Imaging       Date:  1999-02

Review 3.  Iodine-123-labelled fatty acids for myocardial single-photon emission tomography: current status and future perspectives.

Authors:  F F Knapp; J Kropp
Journal:  Eur J Nucl Med       Date:  1995-04

Review 4.  Metabolic imaging using SPECT.

Authors:  Junichi Taki; Ichiro Matsunari
Journal:  Eur J Nucl Med Mol Imaging       Date:  2007-06       Impact factor: 9.236

5.  Both total chain length and position of dimethyl-branching effect the myocardial uptake and retention of radioiodinated analogues of 15-(p-iodophenyl)-3,3-dimethylpentadecanoic acid (DMIPP).

Authors:  F F Knapp; M M Goodman; G Kirsch; S N Reske; J Kropp; H J Biersack; K R Ambrose; C R Lambert; A Goudonnet
Journal:  Ann Nucl Med       Date:  1996-02       Impact factor: 2.668

6.  Combined study with I-123 fatty acid and thallium-201 to assess ischemic myocardium: comparison with thallium redistribution and glucose metabolism.

Authors:  M Kawamoto; N Tamaki; Y Yonekura; E Tadamura; Y Fujibayashi; Y Magata; R Nohara; S Sasayama; K Ikekubo; H Kato
Journal:  Ann Nucl Med       Date:  1994-02       Impact factor: 2.668

7.  Impairment of regional fatty acid uptake in relation to wall motion and thallium-201 uptake in ischaemic but viable myocardium: assessment with iodine-123-labelled beta-methyl-branched fatty acid.

Authors:  J Taki; K Nakajima; I Matsunari; H Bunko; S Takada; N Tonami
Journal:  Eur J Nucl Med       Date:  1995-12

8.  Evaluation of cellular viability by quantitative autoradiographic study of myocardial uptake of a fatty acid analogue in isoproterenol-induced focal rat heart necrosis.

Authors:  T Humbert; C Luu-Duc; M Comet; P Demenge
Journal:  Eur J Nucl Med       Date:  1991

9.  Heterogeneous myocardial distribution of iodine-123 15-(p-iodophenyl)-3-R,S-methylpentadecanoic acid (BMIPP) in patients with hypertrophic cardiomyopathy.

Authors:  Y Takeishi; J Chiba; S Abe; I Tonooka; A Komatani; H Tomoike
Journal:  Eur J Nucl Med       Date:  1992

10.  beta-Methyl-15-p-iodophenylpentadecanoic acid metabolism and kinetics in the isolated rat heart.

Authors:  T R DeGrado; J E Holden; C K Ng; D M Raffel; S J Gatley
Journal:  Eur J Nucl Med       Date:  1989
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