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Literature DB >> 879762

Distribution of gentamicin and amikacin in rabbit tissues.

Abstract

Rabbits were injected intramuscularly with gentamicin and amikacin (15 mg of base per kg), and the antibiotic levels in tissues were determined 20 h after either a single or multiple injections. Disk diffusion assays, with Bacillus subtilis ATCC 6633, were carried out both on homogenates and on supernatants deproteinized with trichloroacetic acid. Both assays indicated that the kidney is the major site of antibiotic deposition. Antibiotic levels increased after multiple doses. Gentamicin levels in other tissues were higher than those of amikacin. The assay of trichloroacetic acid-treated material was more sensitive than the assay of the total homogenate.

Entities: Chemical Species

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Year: 1977 PMID： 879762 PMCID： PMC352113 DOI： 10.1128/AAC.11.6.974

Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN： 0066-4804 Impact factor: 5.191

9 in total

1. Protein measurement with the Folin phenol reagent.

Authors: O H LOWRY; N J ROSEBROUGH; A L FARR; R J RANDALL
Journal: J Biol Chem Date: 1951-11 Impact factor: 5.157

2. Renal extraction of gentamicin in anesthetized dogs.

Authors: P J Chiu; A Brown; G Miller; J F Long
Journal: Antimicrob Agents Chemother Date: 1976-08 Impact factor: 5.191

3. Nephrotoxicity of cephalosporin-gentamicin combinations in rats.

Authors: F C Luft; V Patel; M N Yum; S A Kleit
Journal: Antimicrob Agents Chemother Date: 1976-05 Impact factor: 5.191

4. Concentrations of gentamicin and amikacin in human kidneys.

Authors: C Q Edwards; C R Smith; K L Baughman; J F Rogers; P S Lietman
Journal: Antimicrob Agents Chemother Date: 1976-06 Impact factor: 5.191

5. Binding of antibiotics to tissue homogenates.

Authors: C M Kunin
Journal: J Infect Dis Date: 1970-01 Impact factor: 5.226

6. Renal parenchymal accumulation of aminoglycoside antibiotics in rats.

Authors: F C Luft; S A Kleit
Journal: J Infect Dis Date: 1974-12 Impact factor: 5.226

7. Comparative pharmacokinetics of amikacin and kanamycin.

Authors: J T Clarke; R D Libke; C Regamey; W M Kirby
Journal: Clin Pharmacol Ther Date: 1974-06 Impact factor: 6.875

8. Relation between dose and levels of gentamicin in blood.

Authors: R E Winters; K D Litwack; W L Hewitt
Journal: J Infect Dis Date: 1971-12 Impact factor: 5.226

9. Pharmacology of amikacin in humans.

Authors: G P Bodey; M Valdivieso; R Feld; V Rodriguez
Journal: Antimicrob Agents Chemother Date: 1974-05 Impact factor: 5.191

9 in total

16 in total

1. Pharmacokinetic and nephrotoxic study of gentamicin in rabbits using a new dosage regimen.

Authors: M A Trapote; M A Arévalo; J M Lanao; M G Macias; A S Navarro; M J Alonso; M L Sayalero; A Domínguez-Gil
Journal: Eur J Drug Metab Pharmacokinet Date: 1989 Apr-Jun Impact factor: 2.441

2. Total extraction of aminoglycosides from guinea pig and bullfrog tissues with sodium hydroxide or trichloroacetic acid.

Authors: K E Fox
Journal: Antimicrob Agents Chemother Date: 1989-04 Impact factor: 5.191

3. Effect of fetal exposure to gentamicin on kidneys of young guinea pigs.

Authors: M Lelievre-Pegorier; T Gilbert; R Sakly; A Meulemans; C Merlet-Benichou
Journal: Antimicrob Agents Chemother Date: 1987-01 Impact factor: 5.191

4. Influence of single or multiple doses of gentamicin and netilmicin on their cortical, medullary, and papillary distribution.

Authors: M G Bergeron; S Trottier
Journal: Antimicrob Agents Chemother Date: 1979-05 Impact factor: 5.191