Literature DB >> 738411

Renal accumulation of amikacin, tobramycin and gentamycin in the rat.

L Nieminen, A Kasanen, L Kangas, E Sairio, M Anttila.   

Abstract

Free and total concentrations of amikacin, tobramycin and gentamycin were measured separately in the rat kidney after equal weight by weight doses. The accumulation of aminoglycosides followed the order amikacin less than tobramycin less than gentamycin. The ratio between free and total aminoglycosides was similar (about 0.6) in all 3 aminoglycosides and independent on the length of administration.

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Year:  1978        PMID： 738411     DOI： 10.1007/bf01981456

Source DB:  PubMed          Journal:  Experientia        ISSN： 0014-4754


  7 in total

1.  The nephrotoxicity of antimicrobial agents (second of three parts).

Authors:  G B Appel; H C Neu
Journal:  N Engl J Med       Date:  1977-03-31       Impact factor: 91.245

2.  Distribution of gentamicin and amikacin in rabbit tissues.

Authors:  M L Kornguth; C M Kunin
Journal:  Antimicrob Agents Chemother       Date:  1977-06       Impact factor: 5.191

3.  Binding of antibiotics to tissue homogenates.

Authors:  C M Kunin
Journal:  J Infect Dis       Date:  1970-01       Impact factor: 5.226

4.  Renal parenchymal accumulation of aminoglycoside antibiotics in rats.

Authors:  F C Luft; S A Kleit
Journal:  J Infect Dis       Date:  1974-12       Impact factor: 5.226

5.  Persistence of sisomicin and gentamicin in renal cortex and medulla compared with other organs and serum of rats.

Authors:  J Fabre; M Rudhardt; P Blanchard; C Regamey
Journal:  Kidney Int       Date:  1976-12       Impact factor: 10.612

6.  Comparative nephrotoxicities of netilmicin and gentamicin in rats.

Authors:  F C Luft; M N Yum; S A Kleit
Journal:  Antimicrob Agents Chemother       Date:  1976-11       Impact factor: 5.191

7.  Controlled comparison of amikacin and gentamicin.

Authors:  C R Smith; K L Baughman; C Q Edwards; J F Rogers; P S Lietman
Journal:  N Engl J Med       Date:  1977-02-17       Impact factor: 91.245
  7 in total
  1 in total

1.  Supra-normal sensitivity to ototoxic antibiotic of the developing rat cochlea.

Authors:  E Carlier; R Pujol
Journal:  Arch Otorhinolaryngol       Date:  1980
  1 in total

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