Literature DB >> 2991428

The physical state of human papillomavirus type 16 DNA in benign and malignant genital tumours.

M Dürst, A Kleinheinz, M Hotz, L Gissmann.   

Abstract

Cloned DNA from human papillomavirus (HPV) type 16 was subjected to restriction enzyme analysis. A genome size of 7.8 +/- 0.1 kb was determined and restriction maps were prepared. Fragments of HPV 16 DNA were nick-translated and hybridized with fragments of HPV 6b DNA. The two genomes appeared to be colinear. The physical state of HPV 16 DNA in genital tumours was analysed. In each of six benign tumours the viral DNA was detected exclusively as 8 kb circles. In four malignant tumours the viral DNA appeared to be integrated within the host genome but one cervical carcinoma and one case of Bowen's disease also contained oligomeric episomal molecules of viral DNA. One cervical carcinoma (WV 2965), containing only integrated viral DNA, was examined in detail. HPV 16 DNA was integrated as head-to-tail tandem repeats at more than one site. Three virus/cell junction fragments from this tumour were cloned. Two contained lengths of repetitive cellular DNA and one a length of apparently single copy cellular DNA.

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Year:  1985        PMID： 2991428     DOI： 10.1099/0022-1317-66-7-1515

Source DB:  PubMed          Journal:  J Gen Virol        ISSN： 0022-1317            Impact factor:   3.891


  132 in total

1.  Intranuclear localization of human papillomavirus 16 E7 during transformation and preferential binding of E7 to the Rb family member p130.

Authors:  K Smith-McCune; D Kalman; C Robbins; S Shivakumar; L Yuschenkoff; J M Bishop
Journal:  Proc Natl Acad Sci U S A       Date:  1999-06-08       Impact factor: 11.205

2.  E6-associated protein is required for human papillomavirus type 16 E6 to cause cervical cancer in mice.

Authors:  Anny Shai; Henry C Pitot; Paul F Lambert
Journal:  Cancer Res       Date:  2010-06-08       Impact factor: 12.701

3.  Viral and bacterial aetiologies of epithelial ovarian cancer.

Authors:  S Shanmughapriya; G Senthilkumar; K Vinodhini; B C Das; N Vasanthi; K Natarajaseenivasan
Journal:  Eur J Clin Microbiol Infect Dis       Date:  2012-03-09       Impact factor: 3.267

Review 4.  Laboratory techniques in the investigation of human papillomavirus infection.

Authors:  E M de Villiers
Journal:  Genitourin Med       Date:  1992-02

5.  Chromosomal insertion of human papillomavirus 18 sequences in HeLa cells detected by nonisotopic in situ hybridization and reflection contrast microscopy.

Authors:  P F Ambros; H I Karlic
Journal:  Hum Genet       Date:  1987-11       Impact factor: 4.132

6.  Human papillomavirus detection in paraffin-embedded cervical carcinomas and metastases of the carcinomas by the polymerase chain reaction.

Authors:  E C Claas; W J Melchers; H C van der Linden; J Lindeman; W G Quint
Journal:  Am J Pathol       Date:  1989-10       Impact factor: 4.307

7.  Examination of the pRb-dependent and pRb-independent functions of E7 in vivo.

Authors:  Scott Balsitis; Fred Dick; Denis Lee; Linda Farrell; R Katherine Hyde; Anne E Griep; Nicholas Dyson; Paul F Lambert
Journal:  J Virol       Date:  2005-09       Impact factor: 5.103

8.  Identification of differentially expressed genes in HPV-positive and HPV-negative oropharyngeal squamous cell carcinomas.

Authors:  Ivan Martinez; Jun Wang; Kenosha F Hobson; Robert L Ferris; Saleem A Khan
Journal:  Eur J Cancer       Date:  2006-10-31       Impact factor: 9.162

9.  Study of viral integration of HPV-16 in young patients with LSIL.

Authors:  G Gallo; M Bibbo; L Bagella; A Zamparelli; F Sanseverino; M R Giovagnoli; A Vecchione; A Giordano
Journal:  J Clin Pathol       Date:  2003-07       Impact factor: 3.411

10.  Integration of human papillomavirus type 16 into the human genome correlates with a selective growth advantage of cells.

Authors:  S Jeon; B L Allen-Hoffmann; P F Lambert
Journal:  J Virol       Date:  1995-05       Impact factor: 5.103
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