Literature DB >> 8790326

Long-range repression in the Drosophila embryo.

H N Cai1, D N Arnosti, M Levine.   

Abstract

Transcriptional repressors can be characterized by their range of action on promoters and enhancers. Short-range repressors interact over distances of 50-150 bp to inhibit, or quench, either upstream activators or the basal transcription complex. In contrast, long-range repressors act over several kilobases to silence basal promoters. We describe recent progress in characterizing the functional properties of one such long-range element in the Drosophila embryo and discuss the contrasting types of gene regulation that are made possible by short- and long-range repressors.

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Year:  1996        PMID： 8790326      PMCID： PMC38424          DOI： 10.1073/pnas.93.18.9309

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  29 in total

1.  The gap protein knirps mediates both quenching and direct repression in the Drosophila embryo.

Authors:  D N Arnosti; S Gray; S Barolo; J Zhou; M Levine
Journal:  EMBO J       Date:  1996-07-15       Impact factor: 11.598

2.  Spatial regulation of zerknüllt: a dorsal-ventral patterning gene in Drosophila.

Authors:  H J Doyle; R Kraut; M Levine
Journal:  Genes Dev       Date:  1989-10       Impact factor: 11.361

Review 3.  Transcriptional repression of eukaryotic promoters.

Authors:  M Levine; J L Manley
Journal:  Cell       Date:  1989-11-03       Impact factor: 41.582

4.  Genes affecting the segmental subdivision of the Drosophila embryo.

Authors:  C Nüsslein-Volhard; H Kluding; G Jürgens
Journal:  Cold Spring Harb Symp Quant Biol       Date:  1985

5.  Role of a conserved retinoic acid response element in rhombomere restriction of Hoxb-1.

Authors:  M Studer; H Pöpperl; H Marshall; A Kuroiwa; R Krumlauf
Journal:  Science       Date:  1994-09-16       Impact factor: 47.728

6.  Short-range transcriptional repressors mediate both quenching and direct repression within complex loci in Drosophila.

Authors:  S Gray; M Levine
Journal:  Genes Dev       Date:  1996-03-15       Impact factor: 11.361

7.  Identification of a Stat gene that functions in Drosophila development.

Authors:  R Yan; S Small; C Desplan; C R Dearolf; J E Darnell
Journal:  Cell       Date:  1996-02-09       Impact factor: 41.582

8.  Complementary patterns of even-skipped and fushi tarazu expression involve their differential regulation by a common set of segmentation genes in Drosophila.

Authors:  M Frasch; M Levine
Journal:  Genes Dev       Date:  1987-11       Impact factor: 11.361

9.  Isolation, structure, and expression of even-skipped: a second pair-rule gene of Drosophila containing a homeo box.

Authors:  P M Macdonald; P Ingham; G Struhl
Journal:  Cell       Date:  1986-12-05       Impact factor: 41.582

10.  Three hormone receptor-like Drosophila genes encode an identical DNA-binding finger.

Authors:  M Rothe; U Nauber; H Jäckle
Journal:  EMBO J       Date:  1989-10       Impact factor: 11.598
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  36 in total

1.  Relief of gene repression by torso RTK signaling: role of capicua in Drosophila terminal and dorsoventral patterning.

Authors:  G Jiménez; A Guichet; A Ephrussi; J Casanova
Journal:  Genes Dev       Date:  2000-01-15       Impact factor: 11.361

2.  Genome-wide analysis of clustered Dorsal binding sites identifies putative target genes in the Drosophila embryo.

Authors:  Michele Markstein; Peter Markstein; Vicky Markstein; Michael S Levine
Journal:  Proc Natl Acad Sci U S A       Date:  2001-12-18       Impact factor: 11.205

3.  An anteroposterior Dorsal gradient in the Drosophila embryo.

Authors:  A M Huang; J Rusch; M Levine
Journal:  Genes Dev       Date:  1997-08-01       Impact factor: 11.361

4.  The gypsy insulator can function as a promoter-specific silencer in the Drosophila embryo.

Authors:  H N Cai; M Levine
Journal:  EMBO J       Date:  1997-04-01       Impact factor: 11.598

Review 5.  Logic functions of the genomic cis-regulatory code.

Authors:  Sorin Istrail; Eric H Davidson
Journal:  Proc Natl Acad Sci U S A       Date:  2005-03-23       Impact factor: 11.205

Review 6.  How the Dorsal gradient works: insights from postgenome technologies.

Authors:  Joung-Woo Hong; David A Hendrix; Dmitri Papatsenko; Michael S Levine
Journal:  Proc Natl Acad Sci U S A       Date:  2008-12-22       Impact factor: 11.205

7.  Groucho corepressor functions as a cofactor for the Knirps short-range transcriptional repressor.

Authors:  Sandhya Payankaulam; David N Arnosti
Journal:  Proc Natl Acad Sci U S A       Date:  2009-09-28       Impact factor: 11.205

8.  Position-dependent activity of alpha -fetoprotein enhancer element III in the adult liver is due to negative regulation.

Authors:  D K Peyton; T Ramesh; B T Spear
Journal:  Proc Natl Acad Sci U S A       Date:  2000-09-26       Impact factor: 11.205

9.  dCtBP mediates transcriptional repression by Knirps, Krüppel and Snail in the Drosophila embryo.

Authors:  Y Nibu; H Zhang; E Bajor; S Barolo; S Small; M Levine
Journal:  EMBO J       Date:  1998-12-01       Impact factor: 11.598

10.  Groucho and dCtBP mediate separate pathways of transcriptional repression in the Drosophila embryo.

Authors:  H Zhang; M Levine
Journal:  Proc Natl Acad Sci U S A       Date:  1999-01-19       Impact factor: 11.205
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