OBJECTIVES: To determine rates of other atopic manifestations in people with peanut allergy and the prevalence of such allergy in their families. DESIGN: A survey of people with self reported peanut allergy and people referred by their general practitioner for suspected peanut allergy; survey and skin testing of 50 children with reported peanut allergy and their available first degree relatives. SUBJECTS: 622 adults and children with reported, suspected, or known peanut allergy. MAIN OUTCOME MEASURES: Prevalence of peanut allergy and other allergies in the families of people with peanut allergy. RESULTS: 622 valid completed questionnaires were returned out of the 833 questionnaires dispatched (74.7%). All forms of atopy were both more common in successive generations (P < 0.0001) and more common in maternal than paternal relatives (P < 0.0001). Peanut allergy was reported by 0.1% (3/2409) of grandparents, 0.6% (7/1213) of aunts and uncles, 1.6% (19/1218) of parents, and 6.9% (42/610) of siblings. Consumption of peanuts while pregnant or breast feeding was more common among mothers of probands aged < or = 5 years than mothers of probands aged > 5 years (P < 0.001). Age of onset correlated inversely with year of birth (r = -0.6, P < 0.001). Skin prick testing of 50 children with reported peanut allergy and their families: 7 probands (14%) had a negative result for peanut. Peanut allergy was refuted by food challenge in all those tested (5/7). No parent and 13% (5/39) of siblings had a positive result on skin prick testing for peanut. Two of these siblings had negative challenge with peanuts. The prevalence of peanut allergy in siblings is therefore 3/39 (7%). CONCLUSIONS: Peanut allergy is more common in siblings of people with peanut allergy than in the parents or the general population. Its apparently increasing prevalence may reflect a general increase of atopy, which is inherited more commonly from the mother. Peanut allergy is presenting earlier in life, possibly reflecting increased consumption of peanut by pregnant and nursing mothers.
OBJECTIVES: To determine rates of other atopic manifestations in people with peanutallergy and the prevalence of such allergy in their families. DESIGN: A survey of people with self reported peanutallergy and people referred by their general practitioner for suspected peanutallergy; survey and skin testing of 50 children with reported peanutallergy and their available first degree relatives. SUBJECTS: 622 adults and children with reported, suspected, or known peanutallergy. MAIN OUTCOME MEASURES: Prevalence of peanutallergy and other allergies in the families of people with peanutallergy. RESULTS: 622 valid completed questionnaires were returned out of the 833 questionnaires dispatched (74.7%). All forms of atopy were both more common in successive generations (P < 0.0001) and more common in maternal than paternal relatives (P < 0.0001). Peanutallergy was reported by 0.1% (3/2409) of grandparents, 0.6% (7/1213) of aunts and uncles, 1.6% (19/1218) of parents, and 6.9% (42/610) of siblings. Consumption of peanuts while pregnant or breast feeding was more common among mothers of probands aged < or = 5 years than mothers of probands aged > 5 years (P < 0.001). Age of onset correlated inversely with year of birth (r = -0.6, P < 0.001). Skin prick testing of 50 children with reported peanutallergy and their families: 7 probands (14%) had a negative result for peanut. Peanutallergy was refuted by food challenge in all those tested (5/7). No parent and 13% (5/39) of siblings had a positive result on skin prick testing for peanut. Two of these siblings had negative challenge with peanuts. The prevalence of peanutallergy in siblings is therefore 3/39 (7%). CONCLUSIONS:Peanutallergy is more common in siblings of people with peanutallergy than in the parents or the general population. Its apparently increasing prevalence may reflect a general increase of atopy, which is inherited more commonly from the mother. Peanutallergy is presenting earlier in life, possibly reflecting increased consumption of peanut by pregnant and nursing mothers.
Authors: J W Yunginger; K G Sweeney; W Q Sturner; L A Giannandrea; J D Teigland; M Bray; P A Benson; J A York; L Biedrzycki; D L Squillace Journal: JAMA Date: 1988-09-09 Impact factor: 56.272
Authors: D W Hide; S Matthews; L Matthews; M Stevens; S Ridout; R Twiselton; C Gant; S H Arshad Journal: J Allergy Clin Immunol Date: 1994-05 Impact factor: 10.793
Authors: Scott H Sicherer; Robert A Wood; Donald Stablein; Robert Lindblad; A Wesley Burks; Andrew H Liu; Stacie M Jones; David M Fleischer; Donald Y M Leung; Hugh A Sampson Journal: J Allergy Clin Immunol Date: 2010-10-28 Impact factor: 10.793
Authors: A Wesley Burks; Stacie M Jones; Joshua A Boyce; Scott H Sicherer; Robert A Wood; Amal Assa'ad; Hugh A Sampson Journal: Pediatrics Date: 2011-10-10 Impact factor: 7.124