Literature DB >> 8788022

Variability of genotype-specific penetrance probabilities in the calculation of risk support intervals.

S M Leal1, J Ott.   

Abstract

Previously, a maximum likelihood method was described to construct a support interval for the risk. This method is extended to incorporate genotype specific penetrance probabilities in the calculation of a risk support interval. As an empirical example, the support interval for the risk is calculated for a member of a published breast-ovarian cancer kindred.

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Year:  1995        PMID： 8788022      PMCID： PMC6141013          DOI： 10.1002/gepi.1370120655

Source DB:  PubMed          Journal:  Genet Epidemiol        ISSN： 0741-0395            Impact factor:   2.135


  11 in total

1.  Approximate confidence intervals for risk prediction in genetic counseling.

Authors:  K Lange
Journal:  Am J Hum Genet       Date:  1986-05       Impact factor: 11.025

2.  Recurrence risks for multifactorial inheritance.

Authors:  C Smith
Journal:  Am J Hum Genet       Date:  1971-11       Impact factor: 11.025

3.  Evaluating the uncertainty of risk prediction in genetic counseling: a Bayesian approach.

Authors:  A Rogatko
Journal:  Am J Med Genet       Date:  1988-11

4.  Risk calculations under heterogeneity.

Authors:  D E Weeks; J Ott
Journal:  Am J Hum Genet       Date:  1989-11       Impact factor: 11.025

5.  Easy calculations of lod scores and genetic risks on small computers.

Authors:  G M Lathrop; J M Lalouel
Journal:  Am J Hum Genet       Date:  1984-03       Impact factor: 11.025

6.  Genetic counseling in rare syndromes: a resampling method for determining an approximate confidence interval for gene location with linkage data from a single pedigree.

Authors:  G K Suthers; S R Wilson
Journal:  Am J Hum Genet       Date:  1990-07       Impact factor: 11.025

7.  A likelihood approach to calculating risk support intervals.

Authors:  S M Leal; J Ott
Journal:  Am J Hum Genet       Date:  1994-05       Impact factor: 11.025

8.  Genetic linkage analysis in familial breast and ovarian cancer: results from 214 families. The Breast Cancer Linkage Consortium.

Authors:  D F Easton; D T Bishop; D Ford; G P Crockford
Journal:  Am J Hum Genet       Date:  1993-04       Impact factor: 11.025

9.  Genetic heterogeneity and localization of a familial breast-ovarian cancer gene on chromosome 17q12-q21.

Authors:  S A Smith; D F Easton; D Ford; J Peto; K Anderson; D Averill; M Stratton; M Ponder; C Pye; B A Ponder
Journal:  Am J Hum Genet       Date:  1993-04       Impact factor: 11.025

10.  Genetic analysis of breast cancer in the cancer and steroid hormone study.

Authors:  E B Claus; N Risch; W D Thompson
Journal:  Am J Hum Genet       Date:  1991-02       Impact factor: 11.025
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