Literature DB >> 8460642

Genetic heterogeneity and localization of a familial breast-ovarian cancer gene on chromosome 17q12-q21.

S A Smith1, D F Easton, D Ford, J Peto, K Anderson, D Averill, M Stratton, M Ponder, C Pye, B A Ponder.   

Abstract

In a study of 31 breast cancer families and 12 breast-ovarian cancer families, we have obtained clear evidence of linkage to markers on chromosome 17q in the families with ovarian cancer (maximum lod score 3.34 at theta = .04) but only weak evidence in those without ovarian cancer. Recombinant events indicate that the gene lies between D17S588 and D17S250.

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Year:  1993        PMID： 8460642      PMCID： PMC1682078     

Source DB:  PubMed          Journal:  Am J Hum Genet        ISSN： 0002-9297            Impact factor:   11.025


  6 in total

1.  Dinucleotide repeat polymorphisms at the D17S250 and D17S261 loci.

Authors:  J L Weber; A E Kwitek; P E May; M R Wallace; F S Collins; D H Ledbetter
Journal:  Nucleic Acids Res       Date:  1990-08-11       Impact factor: 16.971

2.  Closing in on a breast cancer gene on chromosome 17q.

Authors:  J M Hall; L Friedman; C Guenther; M K Lee; J L Weber; D M Black; M C King
Journal:  Am J Hum Genet       Date:  1992-06       Impact factor: 11.025

3.  A mapped set of DNA markers for human chromosome 17.

Authors:  Y Nakamura; M Lathrop; P O'Connell; M Leppert; D Barker; E Wright; M Skolnick; S Kondoleon; M Litt; J M Lalouel
Journal:  Genomics       Date:  1988-05       Impact factor: 5.736

4.  Familial breast-ovarian cancer locus on chromosome 17q12-q23.

Authors:  S A Narod; J Feunteun; H T Lynch; P Watson; T Conway; J Lynch; G M Lenoir
Journal:  Lancet       Date:  1991-07-13       Impact factor: 79.321

5.  Linkage of early-onset familial breast cancer to chromosome 17q21.

Authors:  J M Hall; M K Lee; B Newman; J E Morrow; L A Anderson; B Huey; M C King
Journal:  Science       Date:  1990-12-21       Impact factor: 47.728

6.  Genetic linkage analysis in familial breast and ovarian cancer: results from 214 families. The Breast Cancer Linkage Consortium.

Authors:  D F Easton; D T Bishop; D Ford; G P Crockford
Journal:  Am J Hum Genet       Date:  1993-04       Impact factor: 11.025
  6 in total
  19 in total

1.  Biological indices in the assessment of breast cancer.

Authors:  A S Leong; A K Lee
Journal:  Clin Mol Pathol       Date:  1995-10

2.  Modifying effect of reproductive risk factors on the age at onset of breast cancer for German BRCA1 mutation carriers.

Authors:  J Chang-Claude; H Becher; N Eby; G Bastert; J Wahrendorf; U Hamann
Journal:  J Cancer Res Clin Oncol       Date:  1997       Impact factor: 4.553

3.  Evidence for genetic anticipation in non-Mendelian diseases.

Authors:  A D Paterson; J L Kennedy; A Petronis
Journal:  Am J Hum Genet       Date:  1996-07       Impact factor: 11.025

4.  Variability of genotype-specific penetrance probabilities in the calculation of risk support intervals.

Authors:  S M Leal; J Ott
Journal:  Genet Epidemiol       Date:  1995       Impact factor: 2.135

5.  Genetic mapping of the BRCA1 region on chromosome 17q21.

Authors:  H Albertsen; R Plaetke; L Ballard; E Fujimoto; J Connolly; E Lawrence; P Rodriguez; M Robertson; P Bradley; B Milner
Journal:  Am J Hum Genet       Date:  1994-03       Impact factor: 11.025

6.  Loss of the tumor suppressor spinophilin (PPP1R9B) increases the cancer stem cell population in breast tumors.

Authors:  I Ferrer; E M Verdugo-Sivianes; M A Castilla; R Melendez; J J Marin; S Muñoz-Galvan; J L Lopez-Guerra; B Vieites; M J Ortiz-Gordillo; J M De León; J M Praena-Fernandez; M Perez; J Palacios; A Carnero
Journal:  Oncogene       Date:  2015-09-21       Impact factor: 9.867

7.  Linkage analysis of 26 Canadian breast and breast-ovarian cancer families.

Authors:  P Tonin; R Moslehi; R Green; B Rosen; D Cole; N Boyd; C Cutler; R Margolese; R Carter; B McGillivray
Journal:  Hum Genet       Date:  1995-05       Impact factor: 4.132

Review 8.  Hereditary breast cancer and family cancer syndromes.

Authors:  H T Lynch; J Lynch; T Conway; P Watson; J Feunteun; G Lenoir; S Narod; R Fitzgibbons
Journal:  World J Surg       Date:  1994 Jan-Feb       Impact factor: 3.352

9.  Genetic linkage analysis in familial breast and ovarian cancer: results from 214 families. The Breast Cancer Linkage Consortium.

Authors:  D F Easton; D T Bishop; D Ford; G P Crockford
Journal:  Am J Hum Genet       Date:  1993-04       Impact factor: 11.025

10.  Absence of linkage to the ataxia telangiectasia locus in familial breast cancer.

Authors:  R Wooster; D Ford; J Mangion; B A Ponder; J Peto; D F Easton; M R Stratton
Journal:  Hum Genet       Date:  1993-08       Impact factor: 4.132
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