Literature DB >> 8761447

The chemical mechanism of beta-haematin formation studied by Mössbauer spectroscopy.

P A Adams1, T J Egan, D C Ross, J Silver, P J Marsh.   

Abstract

Spontaneous formation of beta-haematin (malaria pigment) from haematin in acetate solution follows pseudo-zero-order and not autocatalytic kinetics. Acetate appears to facilitate the reaction by solubilizing the haematin and acting as a phase-transfer catalyst, a role which, in vivo, could be fulfilled by carboxylic acids or amino acids.

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Year:  1996        PMID： 8761447      PMCID： PMC1217583          DOI： 10.1042/bj3180025

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  11 in total

1.  The iron environment in heme and heme-antimalarial complexes of pharmacological interest.

Authors:  P A Adams; P A Berman; T J Egan; P J Marsh; J Silver
Journal:  J Inorg Biochem       Date:  1996-07       Impact factor: 4.155

2.  Inhibition by chloroquine of a novel haem polymerase enzyme activity in malaria trophozoites.

Authors:  A F Slater; A Cerami
Journal:  Nature       Date:  1992-01-09       Impact factor: 49.962

3.  Synthesis of beta-hematin by dehydrohalogenation of hemin.

Authors:  D S Bohle; J B Helms
Journal:  Biochem Biophys Res Commun       Date:  1993-06-15       Impact factor: 3.575

4.  Quinoline anti-malarial drugs inhibit spontaneous formation of beta-haematin (malaria pigment).

Authors:  T J Egan; D C Ross; P A Adams
Journal:  FEBS Lett       Date:  1994-09-19       Impact factor: 4.124

5.  An iron-carboxylate bond links the heme units of malaria pigment.

Authors:  A F Slater; W J Swiggard; B R Orton; W D Flitter; D E Goldberg; A Cerami; G B Henderson
Journal:  Proc Natl Acad Sci U S A       Date:  1991-01-15       Impact factor: 11.205

6.  Plasmodium hemozoin formation mediated by histidine-rich proteins.

Authors:  D J Sullivan; I Y Gluzman; D E Goldberg
Journal:  Science       Date:  1996-01-12       Impact factor: 47.728

7.  Malarial haemozoin/beta-haematin supports haem polymerization in the absence of protein.

Authors:  A Dorn; R Stoffel; H Matile; A Bubendorf; R G Ridley
Journal:  Nature       Date:  1995-03-16       Impact factor: 49.962

8.  Hemoglobin degradation in the human malaria pathogen Plasmodium falciparum: a catabolic pathway initiated by a specific aspartic protease.

Authors:  D E Goldberg; A F Slater; R Beavis; B Chait; A Cerami; G B Henderson
Journal:  J Exp Med       Date:  1991-04-01       Impact factor: 14.307

9.  Antimalarials increase vesicle pH in Plasmodium falciparum.

Authors:  D J Krogstad; P H Schlesinger; I Y Gluzman
Journal:  J Cell Biol       Date:  1985-12       Impact factor: 10.539

10.  The feeding mechanism of avian malarial parasites.

Authors:  M Aikawa; P K Hepler; C G Huff; H Sprinz
Journal:  J Cell Biol       Date:  1966-02       Impact factor: 10.539
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  6 in total

1.  Fate of haem iron in the malaria parasite Plasmodium falciparum.

Authors:  Timothy J Egan; Jill M Combrinck; Joanne Egan; Giovanni R Hearne; Helder M Marques; Skhumbuzo Ntenteni; B Trevor Sewell; Peter J Smith; Dale Taylor; Donelly A van Schalkwyk; Jason C Walden
Journal:  Biochem J       Date:  2002-07-15       Impact factor: 3.857

2.  Computational studies of new potential antimalarial compounds--stereoelectronic complementarity with the receptor.

Authors:  César Portela; Carlos M M Afonso; Madalena M M Pinto; Maria João Ramos
Journal:  J Comput Aided Mol Des       Date:  2003-09       Impact factor: 3.686

3.  Colorimetric high-throughput screen for detection of heme crystallization inhibitors.

Authors:  Margaret A Rush; Mary Lynn Baniecki; Ralph Mazitschek; Joseph F Cortese; Roger Wiegand; Jon Clardy; Dyann F Wirth
Journal:  Antimicrob Agents Chemother       Date:  2009-03-23       Impact factor: 5.191

4.  The periodontopathogen Porphyromonas gingivalis binds iron protoporphyrin IX in the mu-oxo dimeric form: an oxidative buffer and possible pathogenic mechanism.

Authors:  J W Smalley; J Silver; P J Marsh; A J Birss
Journal:  Biochem J       Date:  1998-05-01       Impact factor: 3.857

5.  Studies on the binding of nitrogenous bases to protoporphyrin IX iron(II) in aqueous solution at high pH values.

Authors:  Jack Silver; Golzar Al-Jaff; Michael T Wilson; Daniel den Engelsen; George R Fern; Terry G Ireland
Journal:  J Biol Inorg Chem       Date:  2022-03-02       Impact factor: 3.862

Review 6.  Potential biomarkers and their applications for rapid and reliable detection of malaria.

Authors:  Priyamvada Jain; Babina Chakma; Sanjukta Patra; Pranab Goswami
Journal:  Biomed Res Int       Date:  2014-04-02       Impact factor: 3.411
  6 in total

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