Literature DB >> 8512553

Synthesis of beta-hematin by dehydrohalogenation of hemin.

D S Bohle1, J B Helms.   

Abstract

beta-Hematin, the metalloporphyrin coordination polymer present in malaria pigment, is prepared in high yield by the abstraction of HCl from hemin with a non-coordinating base in strictly anhydrous conditions. The product of this preparation is characterized by elemental analysis, infrared and diffuse reflectance spectroscopies and demonstrated to be identical to prior preparations.

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Year:  1993        PMID： 8512553     DOI： 10.1006/bbrc.1993.1652

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  10 in total

1.  On the preparation of beta-haematin.

Authors:  G Blauer; M Akkawi
Journal:  Biochem J       Date:  2000-03-01       Impact factor: 3.857

2.  Lipophilic mediated assays for beta-hematin inhibitors.

Authors:  Melissa D Carter; Vanessa V Phelan; Rebecca D Sandlin; Brian O Bachmann; David W Wright
Journal:  Comb Chem High Throughput Screen       Date:  2010-03       Impact factor: 1.339

3.  Identification and Mechanistic Evaluation of Hemozoin-Inhibiting Triarylimidazoles Active against Plasmodium falciparum.

Authors:  Kathryn J Wicht; Jill M Combrinck; Peter J Smith; Roger Hunter; Timothy J Egan
Journal:  ACS Med Chem Lett       Date:  2017-01-24       Impact factor: 4.345

4.  The chemical mechanism of beta-haematin formation studied by Mössbauer spectroscopy.

Authors:  P A Adams; T J Egan; D C Ross; J Silver; P J Marsh
Journal:  Biochem J       Date:  1996-08-15       Impact factor: 3.857

5.  The basis of the immunomodulatory activity of malaria pigment (hemozoin).

Authors:  Clare K Carney; Alexandra C Schrimpe; Kristin Halfpenny; Reese S Harry; Crystal M Miller; Malgorzata Broncel; Sarah L Sewell; Jacob E Schaff; Ravinder Deol; Melissa D Carter; David W Wright
Journal:  J Biol Inorg Chem       Date:  2006-07-26       Impact factor: 3.358

6.  The single crystal X-ray structure of β-hematin DMSO solvate grown in the presence of chloroquine, a β-hematin growth-rate inhibitor.

Authors:  Johandie Gildenhuys; Tanya le Roex; Timothy J Egan; Katherine A de Villiers
Journal:  J Am Chem Soc       Date:  2013-01-09       Impact factor: 15.419

7.  Identification of hydroxyeicosatetraenoic acid components of schistosomal hemozoin.

Authors:  Melissa D Carter; S Reese Harry; David W Wright
Journal:  Biochem Biophys Res Commun       Date:  2007-09-24       Impact factor: 3.575

8.  Comparative analysis of gene expression changes mediated by individual constituents of hemozoin.

Authors:  Alexandra C Schrimpe; David W Wright
Journal:  Chem Res Toxicol       Date:  2009-03-16       Impact factor: 3.739

9.  Detergent-Mediated Formation of β-Hematin: Heme Crystallization Promoted by Detergents Implicates Nanostructure Formation for Use as a Biological Mimic.

Authors:  Rebecca D Sandlin; Kim Y Fong; Renata Stiebler; Christopher P Gulka; Jenny E Nesbitt; Matheus P Oliveira; Marcus F Oliveira; David W Wright
Journal:  Cryst Growth Des       Date:  2016-04-11       Impact factor: 4.076

10.  Malaria pigment crystals as magnetic micro-rotors: key for high-sensitivity diagnosis.

Authors:  A Butykai; A Orbán; V Kocsis; D Szaller; S Bordács; E Tátrai-Szekeres; L F Kiss; A Bóta; B G Vértessy; T Zelles; I Kézsmárki
Journal:  Sci Rep       Date:  2013       Impact factor: 4.379
  10 in total

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