Literature DB >> 12033986

Fate of haem iron in the malaria parasite Plasmodium falciparum.

Timothy J Egan1, Jill M Combrinck, Joanne Egan, Giovanni R Hearne, Helder M Marques, Skhumbuzo Ntenteni, B Trevor Sewell, Peter J Smith, Dale Taylor, Donelly A van Schalkwyk, Jason C Walden.   

Abstract

Chemical analysis has shown that Plasmodium falciparum trophozoites contain 61+/-2% of the iron within parasitized erythrocytes, of which 92+/-6% is located within the food vacuole. Of this, 88+/-9% is in the form of haemozoin. (57)Fe-Mössbauer spectroscopy shows that haemozoin is the only detectable iron species in trophozoites. Electron spectroscopic imaging confirms this conclusion.

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Year:  2002        PMID： 12033986      PMCID： PMC1222701          DOI： 10.1042/BJ20020793

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  19 in total

1.  Intraerythrocytic Plasmodium falciparum utilizes only a fraction of the amino acids derived from the digestion of host cell cytosol for the biosynthesis of its proteins.

Authors:  Miriam Krugliak; Jianmin Zhang; Hagai Ginsburg
Journal:  Mol Biochem Parasitol       Date:  2002-02       Impact factor: 1.759

2.  Inhibition by chloroquine of a novel haem polymerase enzyme activity in malaria trophozoites.

Authors:  A F Slater; A Cerami
Journal:  Nature       Date:  1992-01-09       Impact factor: 49.962

3.  The structure of malaria pigment beta-haematin.

Authors:  S Pagola; P W Stephens; D S Bohle; A D Kosar; S K Madsen
Journal:  Nature       Date:  2000-03-16       Impact factor: 49.962

4.  Magnetic and spectroscopic probes for FeOFe linkages in hemin systems.

Authors:  D H O'Keeffe; C H Barlow; G A Smythe; W H Fuchsman; T H Moss; H R Lilienthal; W S Caughey
Journal:  Bioinorg Chem       Date:  1975

5.  Spectrophotometric determination of serum iron at the submicrogram level with a new reagent (ferrozine).

Authors:  P Carter
Journal:  Anal Biochem       Date:  1971-04       Impact factor: 3.365

6.  Inhibition of the peroxidative degradation of haem as the basis of action of chloroquine and other quinoline antimalarials.

Authors:  P Loria; S Miller; M Foley; L Tilley
Journal:  Biochem J       Date:  1999-04-15       Impact factor: 3.857

7.  Identification of isolate-specific proteins on sorbitol-enriched Plasmodium falciparum infected erythrocytes from Gambian patients.

Authors:  S B Aley; J A Sherwood; K Marsh; O Eidelman; R J Howard
Journal:  Parasitology       Date:  1986-06       Impact factor: 3.234

8.  Human malaria parasites in continuous culture.

Authors:  W Trager; J B Jensen
Journal:  Science       Date:  1976-08-20       Impact factor: 47.728

9.  Synchronization of Plasmodium falciparum erythrocytic stages in culture.

Authors:  C Lambros; J P Vanderberg
Journal:  J Parasitol       Date:  1979-06       Impact factor: 1.276

10.  The feeding mechanism of avian malarial parasites.

Authors:  M Aikawa; P K Hepler; C G Huff; H Sprinz
Journal:  J Cell Biol       Date:  1966-02       Impact factor: 10.539
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  69 in total

1.  X-ray structure of glutathione S-transferase from the malarial parasite Plasmodium falciparum.

Authors:  Karin Fritz-Wolf; Andreas Becker; Stefan Rahlfs; Petra Harwaldt; R Heiner Schirmer; Wolfgang Kabsch; Katja Becker
Journal:  Proc Natl Acad Sci U S A       Date:  2003-11-17       Impact factor: 11.205

2.  Antimalarial 9-anilinoacridine compounds directed at hematin.

Authors:  Saranya Auparakkitanon; Wilai Noonpakdee; Raymond K Ralph; William A Denny; Prapon Wilairat
Journal:  Antimicrob Agents Chemother       Date:  2003-12       Impact factor: 5.191

3.  Anti-plasmodial activity of aroylhydrazone and thiosemicarbazone iron chelators: effect on erythrocyte membrane integrity, parasite development and the intracellular labile iron pool.

Authors:  Asikiya Walcourt; Joseph Kurantsin-Mills; John Kwagyan; Babafemi B Adenuga; Danuta S Kalinowski; David B Lovejoy; Darius J R Lane; Des R Richardson
Journal:  J Inorg Biochem       Date:  2013-08-26       Impact factor: 4.155

4.  Speciation and structure of ferriprotoporphyrin IX in aqueous solution: spectroscopic and diffusion measurements demonstrate dimerization, but not mu-oxo dimer formation.

Authors:  Katherine A de Villiers; Catherine H Kaschula; Timothy J Egan; Helder M Marques
Journal:  J Biol Inorg Chem       Date:  2006-09-14       Impact factor: 3.358

5.  Targeting of hematin by the antimalarial pyronaridine.

Authors:  Saranya Auparakkitanon; Soebsakul Chapoomram; Kannika Kuaha; Thamrong Chirachariyavej; Prapon Wilairat
Journal:  Antimicrob Agents Chemother       Date:  2006-06       Impact factor: 5.191

6.  The neutral lipid composition present in the digestive vacuole of Plasmodium falciparum concentrates heme and mediates β-hematin formation with an unusually low activation energy.

Authors:  Anh N Hoang; Rebecca D Sandlin; Aneesa Omar; Timothy J Egan; David W Wright
Journal:  Biochemistry       Date:  2010-11-08       Impact factor: 3.162

7.  Potencies of human immunodeficiency virus protease inhibitors in vitro against Plasmodium falciparum and in vivo against murine malaria.

Authors:  Katherine T Andrews; David P Fairlie; Praveen K Madala; John Ray; David M Wyatt; Petrina M Hilton; Lewis A Melville; Lynette Beattie; Donald L Gardiner; Robert C Reid; Martin J Stoermer; Tina Skinner-Adams; Colin Berry; James S McCarthy
Journal:  Antimicrob Agents Chemother       Date:  2006-02       Impact factor: 5.191

Review 8.  Malarial hemozoin: from target to tool.

Authors:  Lorena M Coronado; Christopher T Nadovich; Carmenza Spadafora
Journal:  Biochim Biophys Acta       Date:  2014-02-17

9.  The single crystal X-ray structure of β-hematin DMSO solvate grown in the presence of chloroquine, a β-hematin growth-rate inhibitor.

Authors:  Johandie Gildenhuys; Tanya le Roex; Timothy J Egan; Katherine A de Villiers
Journal:  J Am Chem Soc       Date:  2013-01-09       Impact factor: 15.419

10.  Glutathione-deficient Plasmodium berghei parasites exhibit growth delay and nuclear DNA damage.

Authors:  Vivian Padín-Irizarry; Emilee E Colón-Lorenzo; Joel Vega-Rodríguez; María Del R Castro; Ricardo González-Méndez; Sylvette Ayala-Peña; Adelfa E Serrano
Journal:  Free Radic Biol Med       Date:  2016-03-04       Impact factor: 7.376
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