| Literature DB >> 8740102 |
M Rodriguez-Zapata1, M Alvarez-Mon, I Salmeron, A Prieto, L Manzano, O J Salmeron, J Carballido.
Abstract
T lymphocytes from 21 untreated patients with acute brucellosis were tested for their proliferative response to polyclonal mitogens. The purified T lymphocytes from these patients showed a defective proliferative response to plant lectins and anti CD3 monoclonal antibodies with respect to the response observed in T lymphocytes from 21 healthy controls (p < 0.05). This defective proliferative response was not corrected by the exogenous addition of interleukin-2 or tumor necrosis factors alpha or beta to the culture medium. After antibiotic therapy, the proliferative response to the mitogens in T lymphocytes was found to be similar to that of the healthy controls (p > 0.05), and significantly higher than that found before treatment (p < 0.05). It was concluded that T lymphocytes from acute brucellosis patients have a defective proliferative response to membrane mitogenic signals, which disappears when the patients are cured after antibiotic treatment.Entities:
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Year: 1996 PMID： 8740102 DOI： 10.1007/bf01713314
Source DB: PubMed Journal: Infection ISSN： 0300-8126 Impact factor: 3.553