Literature DB >> 3500512

Lymphotoxin is an important T cell-derived growth factor for human B cells.

J H Kehrl1, M Alvarez-Mon, G A Delsing, A S Fauci.   

Abstract

Two different assays for B cell growth factors (BCGF) and an antibody against lymphotoxin were used to show that the presence of lymphotoxin in conditioned media derived from normal activated T cells and in a partially purified BCGF accounts for a substantial portion of their B cell growth-promoting activity. A competitive binding assay confirmed the presence of significant amounts of lymphotoxin in the partially purified BCGF. Recombinant lymphotoxin enhanced the proliferation of activated B cells and augmented B cell proliferation and immunoglobulin secretion induced by interleukin-2.

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Year:  1987        PMID： 3500512     DOI： 10.1126/science.3500512

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  28 in total

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7.  Tumor necrosis factor alpha induces expression of human immunodeficiency virus in a chronically infected T-cell clone.

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9.  Diminished T lymphocyte proliferative response to polyclonal mitogens in acute brucellosis patients.

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Review 10.  Pathogenesis of human immunodeficiency virus infection.

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