Literature DB >> 872882

Action of some natural polypeptides on the longitudinal muscle of the guinea pig ileum.

J Széli, E Molina, L Zappia, G Bertaccini.   

Abstract

The structure--activity relationship of some natural tachykinins was investigated in the longitudinal muscle of the guinea pig ileum. The order of potency was eledoisin greater than uperolein greater than substance P greater than phyllomedusin greater than physalaemin. This ratio of activity is different from that observed in other experimental conditions, and in different in vivo or in vitro preparations; it is suggested that the N-terminal part of the molecule of the tachykinins plays a role in determining the degree of potency of these compounds.

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Year:  1977        PMID： 872882     DOI： 10.1016/0014-2999(77)90030-9

Source DB:  PubMed          Journal:  Eur J Pharmacol        ISSN： 0014-2999            Impact factor:   4.432


  9 in total

1.  Evidence for the release of endogenous substance P from intestinal nerves.

Authors:  R Franco; M Costa; J B Furness
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1979-04       Impact factor: 3.000

2.  Action of some natural peptides on the stomach of the anaesthetized rat.

Authors:  G Bertaccini; G Coruzzi
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1977-06       Impact factor: 3.000

3.  Effect of substance P and its natural analogues on gastric emptying of the conscious rat.

Authors:  G Bertaccini; R de Castiglione; C Scarpignato
Journal:  Br J Pharmacol       Date:  1981-02       Impact factor: 8.739

4.  Antidiuretic activities of substance P and its analogs.

Authors:  M Ukai; T Nagase; M Hirohashi; N Yanaihara
Journal:  Experientia       Date:  1981-05-15

5.  Substance P can contract the longitudinal muscle of the guinea-pig small intestine by releasing intracellular calcium.

Authors:  P Holzer; I T Lippe
Journal:  Br J Pharmacol       Date:  1984-05       Impact factor: 8.739

6.  Innervation of the muscularis mucosae of canine proximal colon.

Authors:  F Angel; V L Go; J H Szurszewski
Journal:  J Physiol       Date:  1984-12       Impact factor: 5.182

7.  Effect of substitution of glycine by D- or L-alanine on the activity of the C-terminal hexapeptide analogue of substance P on isolated guinea-pig ileum.

Authors:  A W Lipkowski; S Drabarek; T Majewski; A M Konecka; B Sadowski
Journal:  Experientia       Date:  1981-05-15

8.  Substance P action on phosphoinositides in guinea-pig intestinal muscle: a possible transduction mechanism?

Authors:  P Holzer; I T Lippe
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1985-03       Impact factor: 3.000

9.  Comparison of cardiovascular and bronchoconstrictor effects of substance P, substance K and other tachykinins.

Authors:  X Hua; J M Lundberg; E Theodorsson-Norheim; E Brodin
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1984-12       Impact factor: 3.000
  9 in total

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