Literature DB >> 6163494

Effect of substance P and its natural analogues on gastric emptying of the conscious rat.

G Bertaccini, R de Castiglione, C Scarpignato.   

Abstract

1 Substance P and its natural analogues were tested for their effect on gastric emptying in the rat. 2 Substance P and kassinin were virtually inactive even at the maximum dose tests. 3 The other tachykinins significantly delayed gastric emptying their effect being quite remarkable with 100 micrograms/kg. The lowest doses (30 microgram/kg) caused a slight and non-significant increase in emptying rate. 4 The effect on gastric emptying was most probably correlated with a spasmogenic effect on the gastroduodenal junction, as pointed out in previous work.

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Year:  1981        PMID： 6163494      PMCID： PMC2071498          DOI： 10.1111/j.1476-5381.1981.tb09116.x

Source DB:  PubMed          Journal:  Br J Pharmacol        ISSN： 0007-1188            Impact factor:   8.739


  10 in total

1.  Action of bombesin on the motility of the stomach.

Authors:  G Bertaccini; M Impicciatore
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1975       Impact factor: 3.000

2.  Effects of natural analogues of substance P on the motility of human gastrointestinal tract in vitro.

Authors:  L Zappia; E Molina; M Sianesi; G Bertaccini
Journal:  J Pharm Pharmacol       Date:  1978-09       Impact factor: 3.765

3.  Action of some natural polypeptides on the longitudinal muscle of the guinea pig ileum.

Authors:  J Széli; E Molina; L Zappia; G Bertaccini
Journal:  Eur J Pharmacol       Date:  1977-06-01       Impact factor: 4.432

4.  Action of some natural peptides on the stomach of the anaesthetized rat.

Authors:  G Bertaccini; G Coruzzi
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1977-06       Impact factor: 3.000

5.  Action of caerulein and related substances on the pyloric sphincter of the anaesthetized rat.

Authors:  G Bertaccini; M Impicciatore; G De Caro
Journal:  Eur J Pharmacol       Date:  1973-06       Impact factor: 4.432

6.  Measurement of blood pressure in unanaesthetized rats and mice.

Authors:  M Gerold; H Tschirky
Journal:  Arzneimittelforschung       Date:  1968-10

Review 7.  Active polypeptides of nonmammalian origin.

Authors:  G Bertaccini
Journal:  Pharmacol Rev       Date:  1976-06       Impact factor: 25.468

8.  Studies on peptides. LXXVI. Synthesis of kassinin, a new frog skin peptide.

Authors:  H Yajima; T Sasaki; H Ogawa; N Juji; T Segawa; Y Nakata
Journal:  Chem Pharm Bull (Tokyo)       Date:  1978-04       Impact factor: 1.645

9.  Action of caerulein on gastric emptying of the conscious rat.

Authors:  C Scarpignato; T Capovilla; G Bertaccini
Journal:  Arch Int Pharmacodyn Ther       Date:  1980-08

10.  Bombesin delays gastric emptying in the rat.

Authors:  C Scarpignato; G Bertaccini
Journal:  Digestion       Date:  1981       Impact factor: 3.216
  10 in total
  7 in total

1.  Effect of substance P on rat gastrointestinal transit.

Authors:  P Silkoff; F Karmeli; E Goldin; A Ewenson; C Gilon; M Chorev; R Laufer; Z Selinger; D Rachmilewitz
Journal:  Dig Dis Sci       Date:  1988-01       Impact factor: 3.199

2.  Histamine H2-antagonists modify gastric emptying in the rat.

Authors:  G Bertaccini; C Scarpignato
Journal:  Br J Pharmacol       Date:  1982-11       Impact factor: 8.739

3.  Loss of intestinal GATA4 prevents diet-induced obesity and promotes insulin sensitivity in mice.

Authors:  Jay V Patankar; Prakash G Chandak; Sascha Obrowsky; Thomas Pfeifer; Clemens Diwoky; Andreas Uellen; Wolfgang Sattler; Rudolf Stollberger; Gerald Hoefler; Akos Heinemann; Michele Battle; Stephen Duncan; Dagmar Kratky; Sanja Levak-Frank
Journal:  Am J Physiol Endocrinol Metab       Date:  2010-12-21       Impact factor: 4.310

4.  Gastric neuropeptides and gastric motor abnormality in streptozotocin-induced diabetic rats: observation for four weeks after streptozotocin.

Authors:  Y Miyamoto; M Yoneda; A Morikawa; H Itoh; I Makino
Journal:  Dig Dis Sci       Date:  2001-08       Impact factor: 3.199

5.  Different effects of the H2-antagonists on gastric emptying in the rat.

Authors:  G Bertaccini; C Scarpignato
Journal:  Experientia       Date:  1982-03-15

6.  Stimulation and inhibition of gastrointestinal propulsion induced by substance P and substance K in the rat.

Authors:  P Holzer
Journal:  Br J Pharmacol       Date:  1985-09       Impact factor: 8.739

7.  Evaluation of Antiulcer Properties of Ethanolic and Hot Aqueous Stem Extracts of Synclisia scabrida on Experimentally Induced Ulcer Models in Albino Mice.

Authors:  Tc Onwudiwe; Po Ughachukwu; Pc Unekwe; Jo Ogamba
Journal:  Ann Med Health Sci Res       Date:  2012-07
  7 in total

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