Literature DB >> 8725944

The molecular basis of somatic hypermutation of immunoglobulin genes.

U Storb1.   

Abstract

Somatic hypermutation amplifies the variable region repertoire of immunoglobulin genes. Recent experimental evidence has thrown light on various molecular models of somatic hypermutation. A link between somatic hypermutation and transcription coupled DNA repair is shaping up.

Mesh：

Year:  1996        PMID： 8725944     DOI： 10.1016/s0952-7915(96)80059-8

Source DB:  PubMed          Journal:  Curr Opin Immunol        ISSN： 0952-7915            Impact factor:   7.486


  22 in total

Review 1.  A new class of errant DNA polymerases provides candidates for somatic hypermutation.

Authors:  B Tippin; M F Goodman
Journal:  Philos Trans R Soc Lond B Biol Sci       Date:  2001-01-29       Impact factor: 6.237

Review 2.  Somatic hypermutation of immunoglobulin and non-immunoglobulin genes.

Authors:  U Storb; H M Shen; N Michael; N Kim
Journal:  Philos Trans R Soc Lond B Biol Sci       Date:  2001-01-29       Impact factor: 6.237

3.  The intrinsic hypermutability of antibody heavy and light chain genes decays exponentially.

Authors:  C Rada; C Milstein
Journal:  EMBO J       Date:  2001-08-15       Impact factor: 11.598

4.  Problems in using statistical analysis of replacement and silent mutations in antibody genes for determining antigen-driven affinity selection.

Authors:  Biplab Bose; Subrata Sinha
Journal:  Immunology       Date:  2005-10       Impact factor: 7.397

Review 5.  Evaluation of molecular models for the affinity maturation of antibodies: roles of cytosine deamination by AID and DNA repair.

Authors:  Mala Samaranayake; Janusz M Bujnicki; Michael Carpenter; Ashok S Bhagwat
Journal:  Chem Rev       Date:  2006-02       Impact factor: 60.622

6.  Cells strongly expressing Ig(kappa) transgenes show clonal recruitment of hypermutation: a role for both MAR and the enhancers.

Authors:  B Goyenechea; N Klix; J Yélamos; G T Williams; A Riddell; M S Neuberger; C Milstein
Journal:  EMBO J       Date:  1997-07-01       Impact factor: 11.598

7.  Sequence dependent hypermutation of the immunoglobulin heavy chain in cultured B cells.

Authors:  M M Lin; M Zhu; M D Scharff
Journal:  Proc Natl Acad Sci U S A       Date:  1997-05-13       Impact factor: 11.205

8.  The mutation patterns in B-cell immunoglobulin receptors reflect the influence of selection acting at multiple time-scales.

Authors:  Gur Yaari; Jennifer I C Benichou; Jason A Vander Heiden; Steven H Kleinstein; Yoram Louzoun
Journal:  Philos Trans R Soc Lond B Biol Sci       Date:  2015-09-05       Impact factor: 6.237

Review 9.  Functions and Malfunctions of Mammalian DNA-Cytosine Deaminases.

Authors:  Sachini U Siriwardena; Kang Chen; Ashok S Bhagwat
Journal:  Chem Rev       Date:  2016-09-01       Impact factor: 60.622

10.  Transcriptional pausing and stalling causes multiple clustered mutations by human activation-induced deaminase.

Authors:  Chandrika Canugovi; Mala Samaranayake; Ashok S Bhagwat
Journal:  FASEB J       Date:  2008-09-04       Impact factor: 5.191
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