Literature DB >> 871368

Cytotoxicity of Ro-07-0582; enhancement by hyperthermia and protection by cysteamine.

E J Hall, M Astor, C Geard, J Biaglow.   

Abstract

The selective cytotoxicity which Ro-07-0582 exhibits towards hypoxic cells is strongly temperature-dependent. This cytotoxicity is reduced by the radical scavenger cysteamine, suggesting that nitro radicals or nitroso intermediates are involved in cell killing by the drug. Chromosome aberrations are not induced by Ro-07-0582 even when the surviving fraction is reduced to 0-01.

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Year:  1977        PMID： 871368      PMCID： PMC2025538          DOI： 10.1038/bjc.1977.122

Source DB:  PubMed          Journal:  Br J Cancer        ISSN： 0007-0920            Impact factor:   7.640


  20 in total

1.  Pre-therapeutic experiments with the fast neutron beam from the Medical Research Council cyclotron. I. The biological and physical advantages and problems of neutron therapy.

Authors:  J F FOWLER; R L MORGAN; C A WOOD
Journal:  Br J Radiol       Date:  1963-02       Impact factor: 3.039

2.  Electron transfer in Ehrlich ascites tumor cells in the presence of nitrofurans.

Authors:  J E Biaglow; O F Nygaard; C L Greenstock
Journal:  Biochem Pharmacol       Date:  1976-02-15       Impact factor: 5.858

3.  Clinical testing of the radiosensitiser Ro-07-0582. I. Dose tolerance, serum and tumour concentrations.

Authors:  A J Gray; S Dische; G E Adams; I R Flockhart; J L Foster
Journal:  Clin Radiol       Date:  1976-04       Impact factor: 2.350

4.  Metronidazole ('Flagyl'): mechanisms of radiosensitization.

Authors:  R L Willson; W A Cramp; R M Ings
Journal:  Int J Radiat Biol Relat Stud Phys Chem Med       Date:  1974-12

5.  Selective chemotherapy of noncycling cells in an in vitro tumor model.

Authors:  R M Sutherland
Journal:  Cancer Res       Date:  1974-12       Impact factor: 12.701

6.  Chemical radioprotection and radiosensitization of mammalian cells growing in vitro.

Authors:  J D Chapman; A P Reuvers; J Borsa; C L Greenstock
Journal:  Radiat Res       Date:  1973-11       Impact factor: 2.841

7.  Split-dose experiments with hypoxic cells. Implications for fractionated and low-dose-rate radiotherapy.

Authors:  E J Hall; S Lehnert; L Roizin-Towle
Journal:  Radiology       Date:  1974-08       Impact factor: 11.105

8.  The histological structure of some human lung cancers and the possible implications for radiotherapy.

Authors:  R H THOMLINSON; L H GRAY
Journal:  Br J Cancer       Date:  1955-12       Impact factor: 7.640

9.  Radiosensitization of C3H mouse mammary tumours by a 2-nitroimidazole drug.

Authors:  P W Sheldon; J L Foster; J F Fowler
Journal:  Br J Cancer       Date:  1974-12       Impact factor: 7.640

10.  Metronidazole (Flagyl): characterization as a cytotoxic drug specific for hypoxic tumour cells.

Authors:  J L Foster; P J Conroy; A J Searle; R L Willson
Journal:  Br J Cancer       Date:  1976-05       Impact factor: 7.640
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  21 in total

1.  Effects of sensitizers on cell respiration: III. The effects of hypoxic cell radiosensitizers on oxidative metabolism and the radiation response of an in vitro tumour model.

Authors:  R E Durand; J E Biaglow; C L Greenstock
Journal:  Br J Cancer Suppl       Date:  1978-06

2.  The nitroimidazoles as radiosensitizers and cytotoxic agents.

Authors:  E J Hall; R Miller; M Astro; F Rini
Journal:  Br J Cancer Suppl       Date:  1978-06

3.  Enhancement of local tumour control by misonidazole and hyperthermia.

Authors:  H B Stone
Journal:  Br J Cancer Suppl       Date:  1978-06

4.  Effect of local hyperthermia on the acute toxicity of misonidazole in mice.

Authors:  J Overgaard
Journal:  Br J Cancer       Date:  1979-01       Impact factor: 7.640

5.  Some factors affecting the specific toxicity of misonidazole towards hypoxic mammalian cells.

Authors:  I J Stratford; P Gray
Journal:  Br J Cancer Suppl       Date:  1978-06

6.  Enhancement of hyperthermochemotherapy for human gastric cancer in nude mice by thermosensitization with nitroimidazoles.

Authors:  S Fujimoto; M Ohta; R D Shrestha; M Kokubun; T Miyoshi; T Mori; N Arimizu; K Okui
Journal:  Br J Cancer       Date:  1988-07       Impact factor: 7.640

7.  Effects on tumour microcirculation in mice of misonidazole and tumour necrosis factor plus hyperthermia.

Authors:  S Fujimoto; K Kobayashi; M Takahashi; C Konno; M Kokubun; M Ohta; R D Shrestha; S Kiuchi
Journal:  Br J Cancer       Date:  1992-01       Impact factor: 7.640

8.  Sulphydryls, ascorbate and oxygen as modifiers of the toxicity and metabolism of misonidazole in vitro.

Authors:  Y C Taylor; A M Rauth
Journal:  Br J Cancer       Date:  1980-06       Impact factor: 7.640

9.  Interaction of misonidazole and WR-2721--II. Modification of tumour radiosensitization.

Authors:  A Rojas; F A Stewart; J Denekamp
Journal:  Br J Cancer       Date:  1983-01       Impact factor: 7.640

10.  Cytotoxicity of metronidazole (Flagyl) and misonidazole (Ro-07-0582): enhancement by lactate.

Authors:  J S Mahood; R L Willson
Journal:  Br J Cancer       Date:  1981-03       Impact factor: 7.640
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