Literature DB >> 7225286

Cytotoxicity of metronidazole (Flagyl) and misonidazole (Ro-07-0582): enhancement by lactate.

J S Mahood, R L Willson.   

Abstract

The cytotoxic activity of metronidazole (Flagyl) and misonidazole (MISO) to hypoxic Chinese hamster ovary (CHO) cells suspended in standard medium in sealed vials and in gassed spinner flasks has been investigated. Flagyl (5 mM) was only cytotoxic at high initial cell densities. However, when lactate (20 mM) was included in the medium the cytotoxicity of Flagyl at low cell densities was considerable, and similar to that of misonidazole under the same conditions. The relevance of this "lactate effect" to in vivo systems, and the possible mechanisms involved, are discussed.

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Year:  1981        PMID： 7225286      PMCID： PMC2010608          DOI： 10.1038/bjc.1981.55

Source DB:  PubMed          Journal:  Br J Cancer        ISSN： 0007-0920            Impact factor:   7.640


  22 in total

1.  Hypoxic cell radiosensitizers: comparative tests of some electron affinic compounds using epidermal cell survival in vivo.

Authors:  J Denekamp; B D Michael; S R Harris
Journal:  Radiat Res       Date:  1974-10       Impact factor: 2.841

2.  Phase 1 study of high-dose metronidazole: a specific in vivo and in vitro radiosensitizer of hypoxic cells.

Authors:  R C Urtasun; J D Chapman; P Band; H R Rabin; C G Fryer; J Sturmwind
Journal:  Radiology       Date:  1975-10       Impact factor: 11.105

3.  Radiosensitization of anoxic cells by metronidazole.

Authors:  J L Foster; R L Willson
Journal:  Br J Radiol       Date:  1973-03       Impact factor: 3.039

Review 4.  Some biochemical aspects of the relationship between the tumor and the host.

Authors:  V S Shapot
Journal:  Adv Cancer Res       Date:  1972       Impact factor: 6.242

5.  Metronidazole ('Flagyl'): mechanisms of radiosensitization.

Authors:  R L Willson; W A Cramp; R M Ings
Journal:  Int J Radiat Biol Relat Stud Phys Chem Med       Date:  1974-12

6.  Tumor and normal tissue response to metronidazole and irradiation in mice.

Authors:  H B Stone; H R Withers
Journal:  Radiology       Date:  1974-11       Impact factor: 11.105

7.  Selective chemotherapy of noncycling cells in an in vitro tumor model.

Authors:  R M Sutherland
Journal:  Cancer Res       Date:  1974-12       Impact factor: 12.701

8.  Increased cell killing by metronidazole and nitrofurazone of hypoxic compared to aerobic mammalian cells.

Authors:  J K Mohindra; A M Rauth
Journal:  Cancer Res       Date:  1976-03       Impact factor: 12.701

9.  Effects of l-(2-nitro-l-imidazolyl)-3-methoxy-2-propanol and 2-methyl-5-nitroimidazole-l-ethanol against anaerobic and aerobic bacteria and protozoa.

Authors:  H N Prince; E Grunberg; E Titsworth; W F DeLorenzo
Journal:  Appl Microbiol       Date:  1969-11

10.  Metronidazole (Flagyl): characterization as a cytotoxic drug specific for hypoxic tumour cells.

Authors:  J L Foster; P J Conroy; A J Searle; R L Willson
Journal:  Br J Cancer       Date:  1976-05       Impact factor: 7.640
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  3 in total

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Journal:  Pharm Res       Date:  2018-05-22       Impact factor: 4.200

2.  Multiple resistance modulators combined with carboplatin for resistant malignancies: a pilot study.

Authors:  D J Stewart; R Goel; M C Cripps; S Huan; J Yau; S Verma
Journal:  Invest New Drugs       Date:  1997       Impact factor: 3.850

3.  Metronidazole decreases viability of DLD-1 colorectal cancer cell line.

Authors:  Anna Sadowska; Rafał Krętowski; Beata Szynaka; Marzanna Cechowska-Pasko; Halina Car
Journal:  Cancer Biother Radiopharm       Date:  2013-06-18       Impact factor: 3.099
  3 in total

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