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Literature DB >> 277212

Some factors affecting the specific toxicity of misonidazole towards hypoxic mammalian cells.

Abstract

The toxic action of misonidazole towards hypoxic mammalian cells has been shown to be a function of serum concentration, with higher serum concentrations enhancing the toxic effect. Added thiols protect cells against misonidazole toxicity. In addition, the action of misonidazole on hypoxic cells labelled with 5-BUdR has been examined. Cells with incroported 5-BUdR are no more sensitive to misonidazole toxicity than are cells without label.

Entities: Chemical

Mesh：

Substances：

Year: 1978 PMID： 277212 PMCID： PMC2149360

Source DB: PubMed Journal: Br J Cancer Suppl ISSN： 0306-9443

9 in total

1. Electron affinic sensitization. V. Radiosensitization of hypoxic bacteria and mammalian cells in vitro by some nitroimidazoles and nitropyrazoles.

Authors: J C Asquith; M E Watts; K Patel; C E Smithen; G E Adams
Journal: Radiat Res Date: 1974-10 Impact factor: 2.841

2. Hypoxic sensitizers: radiobiological studies at the cellular level.

Authors: E J Hall; L Roizin-Towle
Journal: Radiology Date: 1975-11 Impact factor: 11.105

3. Cytotoxicity of two nitroimidazole radiosensitizers in an in vitro tumor model.

Authors: R Sridhar; C Koch; R Suterland
Journal: Int J Radiat Oncol Biol Phys Date: 1976 Nov-Dec Impact factor: 7.038

4. Radiosensitizing and toxic effects on the 2-nitroimidazole Ro-07-0582 in hypoxic mammation cells.

Authors: B A Moore; B Palcic; L D Skarsgard
Journal: Radiat Res Date: 1976-09 Impact factor: 2.841

5. Survival response of asynchronous and synchronous Chinese hamster cells exposed to fluorescent light following 5-bromodeoxyuridine incorporation.

Authors: E Ben-Hur; M M Elkind
Journal: Mutat Res Date: 1972-02 Impact factor: 2.433

6. Sensitization of anoxic mammalian cells to x-rays by triacetoneamine N-oxyl. Survival and toxicity studies.

Authors: L Parker; L D Skarsgard; P T Emmerson
Journal: Radiat Res Date: 1969-06 Impact factor: 2.841

7. Increased sensitivity of mammalian cell cultures to radiomimetic alkylating agents following incorporation of 5-bromodeoxyuridine into cellular DNA.

Authors: R Schindler; L Ramseier; A Grieder
Journal: Biochem Pharmacol Date: 1966-12 Impact factor: 5.858

8. Effect of hyperthermia on differential cytotoxicity of a hypoxic cell radiosensitizer, Ro-07-0582, on mammalian cells in vitro.

Authors: I J Stratford; G E Adams
Journal: Br J Cancer Date: 1977-03 Impact factor: 7.640

9. Cytotoxicity of Ro-07-0582; enhancement by hyperthermia and protection by cysteamine.

Authors: E J Hall; M Astor; C Geard; J Biaglow
Journal: Br J Cancer Date: 1977-06 Impact factor: 7.640

9 in total

7 in total

Some factors affecting the specific toxicity of misonidazole towards hypoxic mammalian cells.

1. Electron affinic sensitization. V. Radiosensitization of hypoxic bacteria and mammalian cells in vitro by some nitroimidazoles and nitropyrazoles.

2. Hypoxic sensitizers: radiobiological studies at the cellular level.

3. Cytotoxicity of two nitroimidazole radiosensitizers in an in vitro tumor model.

4. Radiosensitizing and toxic effects on the 2-nitroimidazole Ro-07-0582 in hypoxic mammation cells.

5. Survival response of asynchronous and synchronous Chinese hamster cells exposed to fluorescent light following 5-bromodeoxyuridine incorporation.

6. Sensitization of anoxic mammalian cells to x-rays by triacetoneamine N-oxyl. Survival and toxicity studies.

7. Increased sensitivity of mammalian cell cultures to radiomimetic alkylating agents following incorporation of 5-bromodeoxyuridine into cellular DNA.

8. Effect of hyperthermia on differential cytotoxicity of a hypoxic cell radiosensitizer, Ro-07-0582, on mammalian cells in vitro.

9. Cytotoxicity of Ro-07-0582; enhancement by hyperthermia and protection by cysteamine.

1. Low concentrations of misonidazole counteract effects of extreme hypoxia on cells in S.

2. Mitochondrial alterations produced by misonidazole: a study using Amoeba proteus as a single-cell model.

3. Sulphydryls, ascorbate and oxygen as modifiers of the toxicity and metabolism of misonidazole in vitro.

4. Split dose cytotoxic experiments with misonidazole.

5. Enhancement of the cytotoxicity of radiosensitizers by modest hyperthermia: the electron-affinity relationship.

6. Ascorbate anion potentiates cytotoxicity of nitro-aromatic compounds under hypoxic and anoxic conditions.

7. Enhancing effect of pre-treatment of cells with misonidazole in hypoxia on their response to melphalan in air.