Literature DB >> 8701087

The JAK-STAT pathway: summary of initial studies and recent advances.

J E Darnell1.   

Abstract

Polypeptides redirect cells by causing immediate changes in gene transcription. A direct connection between polypeptide receptors on the cell surface and genes in the nucleus has been provided by the recognition of the JAK-STAT pathway. Results leading to our present understanding of this pathway are reviewed.

Mesh：

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Year:  1996        PMID： 8701087

Source DB:  PubMed          Journal:  Recent Prog Horm Res        ISSN： 0079-9963


  17 in total

1.  Activation of signal-transducer and activator of transcription 1 (STAT1) in pouchitis.

Authors:  T Kühbacher; P Gionchetti; J Hampe; U Helwig; P Rosenstiel; M Campieri; H J Buhr; S Schreiber
Journal:  Clin Exp Immunol       Date:  2001-03       Impact factor: 4.330

Review 2.  The role of c5b-9 terminal complement complex in activation of the cell cycle and transcription.

Authors:  Matthew Fosbrink; Florin Niculescu; Horea Rus
Journal:  Immunol Res       Date:  2005       Impact factor: 2.829

Review 3.  Roles and regulation of stat family transcription factors in human breast cancer.

Authors:  Charles V Clevenger
Journal:  Am J Pathol       Date:  2004-11       Impact factor: 4.307

4.  The feedback phase of type I interferon induction in dendritic cells requires interferon regulatory factor 8.

Authors:  Prafullakumar Tailor; Tomohiko Tamura; Hee Jeong Kong; Toru Kubota; Mayumi Kubota; Paola Borghi; Lucia Gabriele; Keiko Ozato
Journal:  Immunity       Date:  2007-08-16       Impact factor: 31.745

5.  A Rac GTPase-activating protein, MgcRacGAP, is a nuclear localizing signal-containing nuclear chaperone in the activation of STAT transcription factors.

Authors:  Toshiyuki Kawashima; Ying Chun Bao; Yukinori Minoshima; Yasushi Nomura; Tomonori Hatori; Tetsuya Hori; Tatsuo Fukagawa; Toshiyuki Fukada; Noriko Takahashi; Tetsuya Nosaka; Makoto Inoue; Tomohiro Sato; Mutsuko Kukimoto-Niino; Mikako Shirouzu; Shigeyuki Yokoyama; Toshio Kitamura
Journal:  Mol Cell Biol       Date:  2009-01-21       Impact factor: 4.272

6.  Expansion of spleen myeloid suppressor cells represses NK cell cytotoxicity in tumor-bearing host.

Authors:  Cunren Liu; Shaohua Yu; John Kappes; Jianhua Wang; William E Grizzle; Kurt R Zinn; Huang-Ge Zhang
Journal:  Blood       Date:  2007-01-23       Impact factor: 22.113

Review 7.  Downregulation of signal transducer and activator of transcription 3 by sorafenib: a novel mechanism for hepatocellular carcinoma therapy.

Authors:  Man-Hsin Hung; Wei-Tien Tai; Chung-Wai Shiau; Kuen-Feng Chen
Journal:  World J Gastroenterol       Date:  2014-11-07       Impact factor: 5.742

8.  Inducible STAT3 NH2 terminal mono-ubiquitination promotes BRD4 complex formation to regulate apoptosis.

Authors:  Sutapa Ray; Yingxin Zhao; Mohammad Jamaluddin; Chukwudi B Edeh; Chang Lee; Allan R Brasier
Journal:  Cell Signal       Date:  2014-03-20       Impact factor: 4.315

Review 9.  Molecular approaches towards the inhibition of the signal transducer and activator of transcription 3 (Stat3) protein.

Authors:  Steven Fletcher; James Turkson; Patrick T Gunning
Journal:  ChemMedChem       Date:  2008-08       Impact factor: 3.466

10.  Disruption of transcriptionally active Stat3 dimers with non-phosphorylated, salicylic acid-based small molecules: potent in vitro and tumor cell activities.

Authors:  Steven Fletcher; Jagdeep Singh; Xiaolei Zhang; Peibin Yue; Brent D G Page; Sumaiya Sharmeen; Vijay M Shahani; Wei Zhao; Aaron D Schimmer; James Turkson; Patrick T Gunning
Journal:  Chembiochem       Date:  2009-08-17       Impact factor: 3.164
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