Literature DB >> 18683176

Molecular approaches towards the inhibition of the signal transducer and activator of transcription 3 (Stat3) protein.

Steven Fletcher1, James Turkson, Patrick T Gunning.   

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Year:  2008        PMID： 18683176      PMCID： PMC2603136          DOI： 10.1002/cmdc.200800123

Source DB:  PubMed          Journal:  ChemMedChem        ISSN： 1860-7179            Impact factor:   3.466


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  50 in total

1.  Glide: a new approach for rapid, accurate docking and scoring. 2. Enrichment factors in database screening.

Authors:  Thomas A Halgren; Robert B Murphy; Richard A Friesner; Hege S Beard; Leah L Frye; W Thomas Pollard; Jay L Banks
Journal:  J Med Chem       Date:  2004-03-25       Impact factor: 7.446

2.  Solid-phase synthesis of Stat3 inhibitors incorporating O-carbamoylserine and O-carbamoylthreonine as glutamine mimics.

Authors:  Pijus K Mandal; Patricia A Heard; Zhiyong Ren; Xiaomin Chen; John S McMurray
Journal:  Bioorg Med Chem Lett       Date:  2006-11-06       Impact factor: 2.823

3.  Validating Stat3 in cancer therapy.

Authors:  James E Darnell
Journal:  Nat Med       Date:  2005-06       Impact factor: 53.440

4.  Isoform selective inhibition of STAT1 or STAT3 homo-dimerization via peptidomimetic probes: structural recognition of STAT SH2 domains.

Authors:  Patrick T Gunning; William P Katt; Matthew Glenn; Khandaker Siddiquee; Khandaker Siddique; Joon S Kim; Richard Jove; Saïd M Sebti; James Turkson; Andrew D Hamilton
Journal:  Bioorg Med Chem Lett       Date:  2007-01-27       Impact factor: 2.823

5.  Stat3 activation by Src induces specific gene regulation and is required for cell transformation.

Authors:  J Turkson; T Bowman; R Garcia; E Caldenhoven; R P De Groot; R Jove
Journal:  Mol Cell Biol       Date:  1998-05       Impact factor: 4.272

6.  Long-term human breast carcinoma cell lines of metastatic origin: preliminary characterization.

Authors:  R Cailleau; M Olivé; Q V Cruciger
Journal:  In Vitro       Date:  1978-11

7.  A low-molecular-weight compound discovered through virtual database screening inhibits Stat3 function in breast cancer cells.

Authors:  Hui Song; Renxiao Wang; Shaomeng Wang; Jiayuh Lin
Journal:  Proc Natl Acad Sci U S A       Date:  2005-03-21       Impact factor: 11.205

8.  Choice of STATs and other substrates specified by modular tyrosine-based motifs in cytokine receptors.

Authors:  N Stahl; T J Farruggella; T G Boulton; Z Zhong; J E Darnell; G D Yancopoulos
Journal:  Science       Date:  1995-03-03       Impact factor: 47.728

9.  An oxazole-based small-molecule Stat3 inhibitor modulates Stat3 stability and processing and induces antitumor cell effects.

Authors:  Khandaker A Z Siddiquee; Patrick T Gunning; Matthew Glenn; William P Katt; Shumin Zhang; Christopher Schrock; Christopher Schroeck; Said M Sebti; Richard Jove; Andrew D Hamilton; James Turkson
Journal:  ACS Chem Biol       Date:  2007-12-21       Impact factor: 5.100

Review 10.  Targeting signal-transducer-and-activator-of-transcription-3 for prevention and therapy of cancer: modern target but ancient solution.

Authors:  Bharat B Aggarwal; Gautam Sethi; Kwang Seok Ahn; Santosh K Sandur; Manoj K Pandey; Ajaikumar B Kunnumakkara; Bokyung Sung; Haruyo Ichikawa
Journal:  Ann N Y Acad Sci       Date:  2006-12       Impact factor: 5.691
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  36 in total

Review 1.  Targeting STAT3 in cancer: how successful are we?

Authors:  Peibin Yue; James Turkson
Journal:  Expert Opin Investig Drugs       Date:  2009-01       Impact factor: 6.206

2.  ING4 enhances paclitaxel's effect on colorectal cancer growth in vitro and in vivo.

Authors:  Liyu Cao; Shunhua Chen; Cong Zhang; Cong Chen; Nana Lu; Yan Jiang; Yongping Cai; Yu Yin; Jianming Xu
Journal:  Int J Clin Exp Pathol       Date:  2015-03-01

Review 3.  Chemical modulation of transcription factors.

Authors:  Bianca Wiedemann; Jörn Weisner; Daniel Rauh
Journal:  Medchemcomm       Date:  2018-07-11       Impact factor: 3.597

4.  Correlation analysis of STAT3 and VEGF expression and eosinophil infiltration in nasal polyps.

Authors:  Qingsong Cao; Tao Zhang; Jie Zhang
Journal:  Eur Arch Otorhinolaryngol       Date:  2014-09-25       Impact factor: 2.503

5.  Orally bioavailable small-molecule inhibitor of transcription factor Stat3 regresses human breast and lung cancer xenografts.

Authors:  Xiaolei Zhang; Peibin Yue; Brent D G Page; Tianshu Li; Wei Zhao; Andrew T Namanja; David Paladino; Jihe Zhao; Yuan Chen; Patrick T Gunning; James Turkson
Journal:  Proc Natl Acad Sci U S A       Date:  2012-05-23       Impact factor: 11.205

6.  Antagonism of the Stat3-Stat3 protein dimer with salicylic acid based small molecules.

Authors:  Steven Fletcher; Brent D G Page; Xialoei Zhang; Peibin Yue; Zhi Hua Li; Sumaiya Sharmeen; Jagdeep Singh; Wei Zhao; Aaron D Schimmer; Suzanne Trudel; James Turkson; Patrick T Gunning
Journal:  ChemMedChem       Date:  2011-05-25       Impact factor: 3.466

7.  Identification of Niclosamide as a New Small-Molecule Inhibitor of the STAT3 Signaling Pathway.

Authors:  Xiaomei Ren; Lei Duan; Qiang He; Zhang Zhang; Yi Zhou; Donghai Wu; Jingxuan Pan; Duanqing Pei; Ke Ding
Journal:  ACS Med Chem Lett       Date:  2010-09-07       Impact factor: 4.345

8.  Foxp3 expression in CD4+CD25+Foxp3+ regulatory T cells promotes development of colorectal cancer by inhibiting tumor immunity.

Authors:  Xiao-Wen Zhu; Hai-Zhen Zhu; You-Qing Zhu; Mao-Hui Feng; Jian Qi; Zhi-Fen Chen
Journal:  J Huazhong Univ Sci Technolog Med Sci       Date:  2016-10-18

Review 9.  Repurposing platinum-based chemotherapies for multi-modal treatment of glioblastoma.

Authors:  Nathan B Roberts; Aniket S Wadajkar; Jeffrey A Winkles; Eduardo Davila; Anthony J Kim; Graeme F Woodworth
Journal:  Oncoimmunology       Date:  2016-08-19       Impact factor: 8.110

10.  The small molecule curcumin analog FLLL32 induces apoptosis in melanoma cells via STAT3 inhibition and retains the cellular response to cytokines with anti-tumor activity.

Authors:  Matthew A Bill; James R Fuchs; Chenglong Li; Jennifer Yui; Courtney Bakan; Don M Benson; Eric B Schwartz; Dalia Abdelhamid; Jiayuh Lin; Dale G Hoyt; Stacey L Fossey; Gregory S Young; William E Carson; Pui-Kai Li; Gregory B Lesinski
Journal:  Mol Cancer       Date:  2010-06-25       Impact factor: 27.401
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