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Literature DB >> 19644994

Disruption of transcriptionally active Stat3 dimers with non-phosphorylated, salicylic acid-based small molecules: potent in vitro and tumor cell activities.

Steven Fletcher¹, Jagdeep Singh, Xiaolei Zhang, Peibin Yue, Brent D G Page, Sumaiya Sharmeen, Vijay M Shahani, Wei Zhao, Aaron D Schimmer, James Turkson, Patrick T Gunning.

Abstract

Entities: CellLine Chemical Disease Gene Species

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Year: 2009 PMID： 19644994 PMCID： PMC2919050 DOI： 10.1002/cbic.200900172

Source DB: PubMed Journal: Chembiochem ISSN： 1439-4227 Impact factor: 3.164

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35 in total

1. Identification of a high-affinity phosphopeptide inhibitor of Stat3.

Authors: Zhiyong Ren; Larry A Cabell; Timothy S Schaefer; John S McMurray
Journal: Bioorg Med Chem Lett Date: 2003-02-24 Impact factor: 2.823

2. Inhibition of constitutively active Stat3 suppresses growth of human ovarian and breast cancer cells.

Authors: W M Burke; X Jin; H J Lin; M Huang; R Liu; R K Reynolds; J Lin
Journal: Oncogene Date: 2001-11-29 Impact factor: 9.867

Review 3. The JAK-STAT pathway: summary of initial studies and recent advances.

Authors: J E Darnell
Journal: Recent Prog Horm Res Date: 1996

Review 4. STATs in oncogenesis.

Authors: T Bowman; R Garcia; J Turkson; R Jove
Journal: Oncogene Date: 2000-05-15 Impact factor: 9.867

5. Constitutive activation of Stat3 in human prostate tumors and cell lines: direct inhibition of Stat3 signaling induces apoptosis of prostate cancer cells.

Authors: Linda B Mora; Ralf Buettner; John Seigne; Jose Diaz; Nazeel Ahmad; Roy Garcia; Tammy Bowman; Robert Falcone; Rita Fairclough; Alan Cantor; Carlos Muro-Cacho; Sandy Livingston; James Karras; Julio Pow-Sang; Richard Jove
Journal: Cancer Res Date: 2002-11-15 Impact factor: 12.701

6. Constitutive activation of Stat3 by the Src and JAK tyrosine kinases participates in growth regulation of human breast carcinoma cells.

Authors: R Garcia; T L Bowman; G Niu; H Yu; S Minton; C A Muro-Cacho; C E Cox; R Falcone; R Fairclough; S Parsons; A Laudano; A Gazit; A Levitzki; A Kraker; R Jove
Journal: Oncogene Date: 2001-05-03 Impact factor: 9.867

7. Expression of a retinoic acid receptor gene in myeloid leukemia cells.

Authors: C Wang; J E Curtis; M D Minden; E A McCulloch
Journal: Leukemia Date: 1989-04 Impact factor: 11.528

Review 8. Activated STAT signaling in human tumors provides novel molecular targets for therapeutic intervention.

Authors: Ralf Buettner; Linda B Mora; Richard Jove
Journal: Clin Cancer Res Date: 2002-04 Impact factor: 12.531

9. A high-throughput fluorescence polarization assay for signal transducer and activator of transcription 3.

Authors: Jochen Schust; Thorsten Berg
Journal: Anal Biochem Date: 2004-07-01 Impact factor: 3.365

10. Epidermal growth factor receptor gene-amplified MDA-468 breast cancer cell line and its nonamplified variants.

Authors: J Filmus; J M Trent; M N Pollak; R N Buick
Journal: Mol Cell Biol Date: 1987-01 Impact factor: 4.272

30 in total

1. An activatable multimodal/multifunctional nanoprobe for direct imaging of intracellular drug delivery.

Authors: Rajendra N Mitra; Mona Doshi; Xiaolei Zhang; Jessica C Tyus; Niclas Bengtsson; Steven Fletcher; Brent D G Page; James Turkson; Andre J Gesquiere; Patrick T Gunning; Glenn A Walter; Swadeshmukul Santra
Journal: Biomaterials Date: 2011-11-10 Impact factor: 12.479

2. Applying Small Molecule Signal Transducer and Activator of Transcription-3 (STAT3) Protein Inhibitors as Pancreatic Cancer Therapeutics.

Authors: Carolyn C Arpin; Stephen Mac; Yanlin Jiang; Huiwen Cheng; Michelle Grimard; Brent D G Page; Malgorzata M Kamocka; Sina Haftchenary; Han Su; Daniel P Ball; David A Rosa; Ping-Shan Lai; Rodolfo F Gómez-Biagi; Ahmed M Ali; Rahul Rana; Helmut Hanenberg; Kagan Kerman; Kyle C McElyea; George E Sandusky; Patrick T Gunning; Melissa L Fishel
Journal: Mol Cancer Ther Date: 2016-02-12 Impact factor: 6.261

3. A potent and selective inhibitor for the UBLCP1 proteasome phosphatase.

Authors: Yantao He; Xing Guo; Zhi-Hong Yu; Li Wu; Andrea M Gunawan; Yan Zhang; Jack E Dixon; Zhong-Yin Zhang
Journal: Bioorg Med Chem Date: 2015-03-31 Impact factor: 3.641

Review 4. Phosphotyrosine isosteres: past, present and future.

Authors: Robert A Cerulli; Joshua A Kritzer
Journal: Org Biomol Chem Date: 2019-11-28 Impact factor: 3.876

5. Antagonism of the Stat3-Stat3 protein dimer with salicylic acid based small molecules.

Authors: Steven Fletcher; Brent D G Page; Xialoei Zhang; Peibin Yue; Zhi Hua Li; Sumaiya Sharmeen; Jagdeep Singh; Wei Zhao; Aaron D Schimmer; Suzanne Trudel; James Turkson; Patrick T Gunning
Journal: ChemMedChem Date: 2011-05-25 Impact factor: 3.466

6. Potent and selective phosphopeptide mimetic prodrugs targeted to the Src homology 2 (SH2) domain of signal transducer and activator of transcription 3.

Authors: Pijus K Mandal; Fengqin Gao; Zhen Lu; Zhiyong Ren; Rajagopal Ramesh; J Sanderson Birtwistle; Kumaralal K Kaluarachchi; Xiaomin Chen; Robert C Bast; Warren S Liao; John S McMurray
Journal: J Med Chem Date: 2011-04-26 Impact factor: 7.446