Literature DB >> 8698523

Interleukin-10 protects neonatal mice from lethal group B streptococcal infection.

V Cusumano1, F Genovese, G Mancuso, M Carbone, M T Fera, G Teti.   

Abstract

We investigated the role of interleukin-10 (IL-10) in a neonatal mouse model of lethal group B streptococci (GBS) sepsis. Plasma IL-10 levels significantly increased at 24 and 48 h after GBS inoculation. Neutralization of IL-10 with specific antibodies had no effect on lethality. Administration of recombinant IL-10 at 20 or 4 h before challenge, but not at later times, resulted in decreased tumor necrosis factor alpha levels and improved survival. IL-10 could be potentially useful for the treatment of GBS sepsis.

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Year:  1996        PMID： 8698523      PMCID： PMC174154          DOI： 10.1128/iai.64.7.2850-2852.1996

Source DB:  PubMed          Journal:  Infect Immun        ISSN： 0019-9567            Impact factor:   3.441


  21 in total

1.  Group B streptococcal infection in newborns: prevention at last?

Authors:  C J Baker
Journal:  N Engl J Med       Date:  1986-06-26       Impact factor: 91.245

2.  Production of cytokines by mouse B cells: B lymphomas and normal B cells produce interleukin 10.

Authors:  A O'Garra; G Stapleton; V Dhar; M Pearce; J Schumacher; H Rugo; D Barbis; A Stall; J Cupp; K Moore
Journal:  Int Immunol       Date:  1990       Impact factor: 4.823

3.  Isolation of monoclonal antibodies specific for IL-4, IL-5, IL-6, and a new Th2-specific cytokine (IL-10), cytokine synthesis inhibitory factor, by using a solid phase radioimmunoadsorbent assay.

Authors:  T R Mosmann; J H Schumacher; D F Fiorentino; J Leverah; K W Moore; M W Bond
Journal:  J Immunol       Date:  1990-11-01       Impact factor: 5.422

4.  Isolation and expression of human cytokine synthesis inhibitory factor cDNA clones: homology to Epstein-Barr virus open reading frame BCRFI.

Authors:  P Vieira; R de Waal-Malefyt; M N Dang; K E Johnson; R Kastelein; D F Fiorentino; J E deVries; M G Roncarolo; T R Mosmann; K W Moore
Journal:  Proc Natl Acad Sci U S A       Date:  1991-02-15       Impact factor: 11.205

5.  Ly-1 B (B-1) cells are the main source of B cell-derived interleukin 10.

Authors:  A O'Garra; R Chang; N Go; R Hastings; G Haughton; M Howard
Journal:  Eur J Immunol       Date:  1992-03       Impact factor: 5.532

6.  Prevention of C3 deposition by capsular polysaccharide is a virulence mechanism of type III group B streptococci.

Authors:  M B Marques; D L Kasper; M K Pangburn; M R Wessels
Journal:  Infect Immun       Date:  1992-10       Impact factor: 3.441

7.  Cytokine appearance and effects of anti-tumor necrosis factor alpha antibodies in a neonatal rat model of group B streptococcal infection.

Authors:  G Teti; G Mancuso; F Tomasello
Journal:  Infect Immun       Date:  1993-01       Impact factor: 3.441

Review 8.  Molecular mechanism in tolerance to lipopolysaccharide.

Authors:  H W Ziegler-Heitbrock
Journal:  J Inflamm       Date:  1995

9.  Two types of mouse T helper cell. IV. Th2 clones secrete a factor that inhibits cytokine production by Th1 clones.

Authors:  D F Fiorentino; M W Bond; T R Mosmann
Journal:  J Exp Med       Date:  1989-12-01       Impact factor: 14.307

10.  Interleukin 10(IL-10) inhibits cytokine synthesis by human monocytes: an autoregulatory role of IL-10 produced by monocytes.

Authors:  R de Waal Malefyt; J Abrams; B Bennett; C G Figdor; J E de Vries
Journal:  J Exp Med       Date:  1991-11-01       Impact factor: 14.307
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  22 in total

1.  Human monocyte receptors involved in tumor necrosis factor responses to group B streptococcal products.

Authors:  M Cuzzola; G Mancuso; C Beninati; C Biondo; C von Hunolstein; G Orefici; T Espevik; T H Flo; G Teti
Journal:  Infect Immun       Date:  2000-02       Impact factor: 3.441

2.  Soluble antigens from group B streptococci induce cytokine production in human blood cultures.

Authors:  C von Hunolstein; A Totolian; G Alfarone; G Mancuso; V Cusumano; G Teti; G Orefici
Journal:  Infect Immun       Date:  1997-10       Impact factor: 3.441

3.  Endotoxin-induced lethality in neonatal mice is counteracted by interleukin-10 (IL-10) and exacerbated by anti-IL-10.

Authors:  F Nicoletti; G Mancuso; F A Ciliberti; C Beninati; M Carbone; S Franco; V Cusumano
Journal:  Clin Diagn Lab Immunol       Date:  1997-09

4.  Group B Streptococci Induce Proinflammatory Responses via a Protein Kinase D1-Dependent Pathway.

Authors:  Kirtikumar Upadhyay; Jeoung-Eun Park; Tae Won Yoon; Priyanka Halder; Young-In Kim; Victoria Metcalfe; Ajay J Talati; B Keith English; Ae-Kyung Yi
Journal:  J Immunol       Date:  2017-05-01       Impact factor: 5.422

5.  Role of interleukin 12 in experimental neonatal sepsis caused by group B streptococci.

Authors:  G Mancuso; V Cusumano; F Genovese; M Gambuzza; C Beninati; G Teti
Journal:  Infect Immun       Date:  1997-09       Impact factor: 3.441

6.  Interleukin-18 is an essential element in host resistance to experimental group B streptococcal disease in neonates.

Authors:  Vitaliano Cusumano; Angelina Midiri; Valentina Valeria Cusumano; Antonella Bellantoni; Giuseppe De Sossi; Giuseppe Teti; Concetta Beninati; Giuseppe Mancuso
Journal:  Infect Immun       Date:  2004-01       Impact factor: 3.441

7.  Comparison of the susceptibilities of C57BL/6 and A/J mouse strains to Streptococcus suis serotype 2 infection.

Authors:  María de la Cruz Domínguez-Punaro; Mariela Segura; Danuta Radzioch; Serge Rivest; Marcelo Gottschalk
Journal:  Infect Immun       Date:  2008-06-23       Impact factor: 3.441

8.  Increased weight loss with reduced viral replication in interleukin-10 knock-out mice infected with murine cytomegalovirus.

Authors:  O R Oakley; B A Garvy; S Humphreys; M H Qureshi; C Pomeroy
Journal:  Clin Exp Immunol       Date:  2007-11-14       Impact factor: 4.330

9.  IL-10 up-regulates nitric oxide (NO) synthesis by lipopolysaccharide (LPS)-activated macrophages: improved control of Trypanosoma cruzi infection.

Authors:  F Jacobs; D Chaussabel; C Truyens; V Leclerq; Y Carlier; M Goldman; B Vray
Journal:  Clin Exp Immunol       Date:  1998-07       Impact factor: 4.330

Review 10.  Induction and termination of inflammatory signaling in group B streptococcal sepsis.

Authors:  Julia Wennekamp; Philipp Henneke
Journal:  Immunol Rev       Date:  2008-10       Impact factor: 12.988
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