Literature DB >> 1847510

Isolation and expression of human cytokine synthesis inhibitory factor cDNA clones: homology to Epstein-Barr virus open reading frame BCRFI.

P Vieira1, R de Waal-Malefyt, M N Dang, K E Johnson, R Kastelein, D F Fiorentino, J E deVries, M G Roncarolo, T R Mosmann, K W Moore.   

Abstract

We have demonstrated the existence of human cytokine synthesis inhibitory factor (CSIF) [interleukin 10 (IL-10)]. cDNA clones encoding human IL-10 (hIL-10) were isolated from a tetanus toxin-specific human T-cell clone. Like mouse IL-10, hIL-10 exhibits strong DNA and amino acid sequence homology to an open reading frame in the Epstein-Barr virus, BCRFI. hIL-10 and the BCRFI product inhibit cytokine synthesis by activated human peripheral blood mononuclear cells and by a mouse Th1 clone. Both hIL-10 and mouse IL-10 sustain the viability of a mouse mast cell line in culture, but BCRFI lacks comparable activity in this assay, suggesting that BCRFI may have conserved only a subset of hIL-10 activities.

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Year:  1991        PMID： 1847510      PMCID： PMC50979          DOI： 10.1073/pnas.88.4.1172

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  40 in total

Review 1.  Learning from leprosy: a perspective on immunology and the Third World.

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3.  Production of cytokines by mouse B cells: B lymphomas and normal B cells produce interleukin 10.

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4.  Differential interleukin-2 and interferon-gamma production by human lymphocyte cultures exceptionally resistant to Epstein-Barr virus immortalization.

Authors:  J Gosselin; J Menezes; G Mercier; G Lamoureux; D Oth
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5.  New perspectives on a subclinical form of visceral leishmaniasis.

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6.  B cell stimulatory factor-1 enhances the IgE response of lipopolysaccharide-activated B cells.

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7.  Human Fc gamma RIII: cloning, expression, and identification of the chromosomal locus of two Fc receptors for IgG.

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8.  Absence of gamma interferon and interleukin 2 production during active visceral leishmaniasis.

Authors:  E M Carvalho; R Badaró; S G Reed; T C Jones; W D Johnson
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Review 9.  Immunological unresponsiveness in leprosy.

Authors:  B R Bloom; V Mehra
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10.  Two types of mouse T helper cell. IV. Th2 clones secrete a factor that inhibits cytokine production by Th1 clones.

Authors:  D F Fiorentino; M W Bond; T R Mosmann
Journal:  J Exp Med       Date:  1989-12-01       Impact factor: 14.307
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  185 in total

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Review 4.  Biological properties of interleukin 10.

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7.  Purification and partial amino acid sequence of suppressive lymphokine from a CD8+ CD57+ human T hybridoma.

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8.  Production of interleukin-10 by human bronchogenic carcinoma.

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9.  IL-10 augments CD23 expression on U937 cells and down-regulates IL-4-driven CD23 expression on cultured human blood monocytes: effects of IL-10 and other cytokines on cell phenotype and phagocytosis.

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