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Literature DB >> 9302214

Endotoxin-induced lethality in neonatal mice is counteracted by interleukin-10 (IL-10) and exacerbated by anti-IL-10.

F Nicoletti¹, G Mancuso, F A Ciliberti, C Beninati, M Carbone, S Franco, V Cusumano.

Abstract

The lethal effects occurring in neonatal (<24-h-old) BALB/c mice after challenge with 25 mg of lipopolysaccharide (LPS) per kg of body weight were significantly counteracted by pretreatment with recombinant interleukin-10 (rIL-10; 25 or 50 ng/mouse). Concordantly, blockage of endogenous IL-10 with the SXC1 monoclonal antibody increased LPS-induced mortality. Both IL-10 and SXC1 modulated the release of tumor necrosis factor alpha (TNF-alpha) so that, relative to controls, peak TNF-alpha values after LPS challenge were decreased by rIL-10 and increased by anti-IL-10.

Entities: Chemical Gene Species

Mesh：

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Year: 1997 PMID： 9302214 PMCID： PMC170607 DOI： 10.1128/cdli.4.5.607-610.1997

Source DB: PubMed Journal: Clin Diagn Lab Immunol ISSN： 1071-412X

22 in total

1. Neonatal hypersusceptibility to endotoxin correlates with increased tumor necrosis factor production in mice.

Authors: V Cusumano; G Mancuso; F Genovese; M Cuzzola; M Carbone; J A Cook; J B Cochran; G Teti
Journal: J Infect Dis Date: 1997-07 Impact factor: 5.226

2. Pathogenesis of colonization and infection in a neonatal surgical unit.

Authors: E M Leonard; H K van Saene; P Shears; J Walker; P K Tam
Journal: Crit Care Med Date: 1990-03 Impact factor: 7.598

3. A highly sensitive cell line, WEHI 164 clone 13, for measuring cytotoxic factor/tumor necrosis factor from human monocytes.

Authors: T Espevik; J Nissen-Meyer
Journal: J Immunol Methods Date: 1986-12-04 Impact factor: 2.303

4. Modified immunological status of anti-IL-10 treated mice.

Authors: H Ishida; R Hastings; L Thompson-Snipes; M Howard
Journal: Cell Immunol Date: 1993-05 Impact factor: 4.868

5. Interleukin 10 protects mice against staphylococcal enterotoxin B-induced lethal shock.

Authors: A G Bean; R A Freiberg; S Andrade; S Menon; A Zlotnik
Journal: Infect Immun Date: 1993-11 Impact factor: 3.441

6. Mortality, temporal substrate and insulin responses to endotoxic shock in zero, ten and twenty-eight day old rats.

Authors: W P Zeller; M Goto; L Witek-Janusek; R M Hurley
Journal: Surg Gynecol Obstet Date: 1991-11

7. Efficacy of monoclonal antibody against tumor necrosis factor alpha in an endotoxemic baboon model.

Authors: T E Emerson; D C Lindsey; G J Jesmok; M L Duerr; M A Fournel
Journal: Circ Shock Date: 1992-10

Review 8. Interleukin-10.

Authors: K W Moore; A O'Garra; R de Waal Malefyt; P Vieira; T R Mosmann
Journal: Annu Rev Immunol Date: 1993 Impact factor: 28.527

9. Cytokine appearance and effects of anti-tumor necrosis factor alpha antibodies in a neonatal rat model of group B streptococcal infection.

Authors: G Teti; G Mancuso; F Tomasello
Journal: Infect Immun Date: 1993-01 Impact factor: 3.441

Endotoxin-induced lethality in neonatal mice is counteracted by interleukin-10 (IL-10) and exacerbated by anti-IL-10.

1. Neonatal hypersusceptibility to endotoxin correlates with increased tumor necrosis factor production in mice.

2. Pathogenesis of colonization and infection in a neonatal surgical unit.

3. A highly sensitive cell line, WEHI 164 clone 13, for measuring cytotoxic factor/tumor necrosis factor from human monocytes.

4. Modified immunological status of anti-IL-10 treated mice.

5. Interleukin 10 protects mice against staphylococcal enterotoxin B-induced lethal shock.

6. Mortality, temporal substrate and insulin responses to endotoxic shock in zero, ten and twenty-eight day old rats.

7. Efficacy of monoclonal antibody against tumor necrosis factor alpha in an endotoxemic baboon model.

Review 8. Interleukin-10.

9. Cytokine appearance and effects of anti-tumor necrosis factor alpha antibodies in a neonatal rat model of group B streptococcal infection.

10. Interleukin 10 protects mice from lethal endotoxemia.

1. Hypoxia-inducible factor 2alpha regulates macrophage function in mouse models of acute and tumor inflammation.

2. Prevention and treatment of lethal murine endotoxemia by the novel immunomodulatory agent MFP-14.

3. Cardiac function and circulating cytokines after endotoxin exposure in neonatal mice.

4. IL-10 Has Differential Effects on the Innate and Adaptive Immune Systems of Septic Patients.

5. Mechanism of T-cell mediated protection in newborn mice against a Chlamydia infection.

Review 6. Hypoxia-inducible factors as essential regulators of inflammation.

7. The interaction of oxidative stress response with cytokines in the thyrotoxic rat: is there a link?