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Literature DB >> 8698109

Amylin given by central or peripheral routes decreases gastric emptying and intestinal transit in the rat.

G Clementi¹, A Caruso, V M Cutuli, E de Bernardis, A Prato, M Amico-Roxas.

Abstract

The effect of rat amylin on gastric emptying and intestinal transit in the rat was examined. Amylin administered intracerebroventricularly (1, 2, 2.5 or 4 micrograms/rat) produced the maximal decrease in gastric emptying and intestinal transit at the dose of 2.5 micrograms/rat. Higher doses produced a lower effect. Peripheral administration (25, 50 or 100 micrograms/kg) produced dose-dependent effects. Pre-treatment with neostigmine blocked the effect of amylin when it was centrally injected, while the effect of amylin given peripherally was partially reduced. Pre-treatment with domperidone decreased the inhibitory effect of peripherally injected amylin, but no effect was observed when the peptide was centrally injected.

Entities: Chemical Gene Species

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Year: 1996 PMID： 8698109 DOI： 10.1007/bf01925572

Source DB: PubMed Journal: Experientia ISSN： 0014-4754

14 in total

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Authors: A Ogawa; V Harris; S K McCorkle; R H Unger; K L Luskey
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10. Expression of the rat amylin (IAPP/DAP) gene.

Authors: G J Ferrier; A M Pierson; P M Jones; S R Bloom; S I Girgis; S Legon
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Review 3. Control of energy homeostasis by amylin.

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5. Distinct internalization pathways of human amylin monomers and its cytotoxic oligomers in pancreatic cells.

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6. The ability of insulin to inhibit the formation of amyloid by pro-islet amyloid polypeptide processing intermediates is significantly reduced in the presence of sulfated glycosaminoglycans.

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7. Rationally designed, nontoxic, nonamyloidogenic analogues of human islet amyloid polypeptide with improved solubility.

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8. General amyloid inhibitors? A critical examination of the inhibition of IAPP amyloid formation by inositol stereoisomers.

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9. Regulation of amylin release from cultured rabbit gastric fundic mucosal cells.

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Review 10. Role and Cytotoxicity of Amylin and Protection of Pancreatic Islet β-Cells from Amylin Cytotoxicity.

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