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Literature DB >> 2689229

Secretion of islet amyloid polypeptide in response to glucose.

A Kanatsuka¹, H Makino, H Ohsawa, Y Tokuyama, T Yamaguchi, S Yoshida, M Adachi.

Abstract

The content of islet amyloid polypeptide (IAPP) in isolated rat pancreatic islets was determined by a radioimmunoassay. Reverse-phase high-performance liquid chromatography analysis revealed that a main peak of IAPP immunoreactivity in the extracts from the islets corresponded to a synthetic rat IAPP. Secretion of IAPP from the cells is regulated by the extracellular glucose concentration. Thus, IAPP may be a novel regulator for glucose homeostasis and changes in the secretion perhaps relate to insular amyloid deposits and impaired glucose tolerance in type 2 diabetes mellitus.

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Year: 1989 PMID： 2689229 DOI： 10.1016/0014-5793(89)81527-3

Source DB: PubMed Journal: FEBS Lett ISSN： 0014-5793 Impact factor: 4.124

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Cited

18 in total

1. CGRP receptors mediating CGRP-, adrenomedullin- and amylin-induced relaxation in porcine coronary arteries. Characterization with 'Compound 1' (WO98/11128), a non-peptide antagonist.

Authors: P Hasbak; A Sams; S Schifter; J Longmore; L Edvinsson
Journal: Br J Pharmacol Date: 2001-08 Impact factor: 8.739

9. A mnemonical or negative-co-operativity model for the activation of adenylate cyclase by a common G-protein-coupled calcitonin-gene-related neuropeptide (CGRP)/amylin receptor.

Authors: M Bushfield; A Savage; N J Morris; M D Houslay
Journal: Biochem J Date: 1993-07-01 Impact factor: 3.857

10. High ascorbic acid content in the rat endocrine pancreas.

Authors: A Zhou; N A Thorn
Journal: Diabetologia Date: 1991-11 Impact factor: 10.122

Secretion of islet amyloid polypeptide in response to glucose.

1. CGRP receptors mediating CGRP-, adrenomedullin- and amylin-induced relaxation in porcine coronary arteries. Characterization with 'Compound 1' (WO98/11128), a non-peptide antagonist.

Review 2. Islet amyloid polypeptide--a novel controversy in diabetes research.

3. Amylin given by central or peripheral routes decreases gastric emptying and intestinal transit in the rat.

4. The effects of amylin on carbohydrate metabolism in skeletal muscle in vitro and in vivo.

Review 5. Amylin, amyloid and age-related disease.

6. Non-selective ion channel activity of polymorphic human islet amyloid polypeptide (amylin) double channels.

7. Plasma amylin and insulin concentrations in normoglycemic and hyperglycemic cats.

8. Anti-insulin effects of amylin and calcitonin-gene-related peptide on hepatic glycogen metabolism.

9. A mnemonical or negative-co-operativity model for the activation of adenylate cyclase by a common G-protein-coupled calcitonin-gene-related neuropeptide (CGRP)/amylin receptor.

10. High ascorbic acid content in the rat endocrine pancreas.