Literature DB >> 7582445

Promotion by SR 48692 of gastric emptying and defaecation in rats suggesting a role of endogenous neurotensin.

T Croci1, A Giudice, L Manara, D Gully, G Le Fur.   

Abstract

We investigated the influence of the nonpeptide neurotensin receptor antagonist, SR 48692, administered orally, on gastric emptying and on acute defaecation. SR 48692 dose-dependently (ED50 approximately 0.7 microgram kg-1) increased gastric emptying of a food suspension, but it had no effect on that of a non-caloric meal. SR 48692 also dose-dependently promoted defaecation and increased faecal water content. We suggest that antagonism of endogenous neurotensin accounts for the gastric emptying and defaecation promoting action of SR 48692.

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Year:  1995        PMID： 7582445      PMCID： PMC1908395          DOI： 10.1111/j.1476-5381.1995.tb16343.x

Source DB:  PubMed          Journal:  Br J Pharmacol        ISSN： 0007-1188            Impact factor:   8.739


  5 in total

1.  Effects of neurotensin on the transit of gastrointestinal contents in the rat.

Authors:  P M Hellström; G Nylander; S Rosell
Journal:  Acta Physiol Scand       Date:  1982-06

2.  Effect of the nonpeptide neurotensin antagonist, SR 48692, and two enantiomeric analogs, SR 48527 and SR 49711, on neurotensin binding and contractile responses in guinea pig ileum and colon.

Authors:  C Labbé-Jullié; S Deschaintres; D Gully; G Le Fur; P Kitabgi
Journal:  J Pharmacol Exp Ther       Date:  1994-10       Impact factor: 4.030

3.  Stimulation of faecal excretion in rats by alpha 2-adrenergic antagonists.

Authors:  T Croci; A Bianchetti
Journal:  J Pharm Pharmacol       Date:  1992-04       Impact factor: 3.765

4.  Cloning and expression of a complementary DNA encoding a high affinity human neurotensin receptor.

Authors:  N Vita; P Laurent; S Lefort; P Chalon; X Dumont; M Kaghad; D Gully; G Le Fur; P Ferrara; D Caput
Journal:  FEBS Lett       Date:  1993-02-08       Impact factor: 4.124

5.  Biochemical and pharmacological profile of a potent and selective nonpeptide antagonist of the neurotensin receptor.

Authors:  D Gully; M Canton; R Boigegrain; F Jeanjean; J C Molimard; M Poncelet; C Gueudet; M Heaulme; R Leyris; A Brouard
Journal:  Proc Natl Acad Sci U S A       Date:  1993-01-01       Impact factor: 11.205
  5 in total
  2 in total

1.  Amylin given by central or peripheral routes decreases gastric emptying and intestinal transit in the rat.

Authors:  G Clementi; A Caruso; V M Cutuli; E de Bernardis; A Prato; M Amico-Roxas
Journal:  Experientia       Date:  1996-07-15

2.  CircORC2 is involved in the pathogenesis of slow transit constipation via modulating the signalling of miR-19a and neurotensin/motilin.

Authors:  Yuan-Yuan Wang; Rui-Yun Lu; Ji Shi; Shuai Zhao; Xia Jiang; Xiaosong Gu
Journal:  J Cell Mol Med       Date:  2021-02-24       Impact factor: 5.310
  2 in total

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