Literature DB >> 8698067

Glucose consumption and methionine uptake in low-grade gliomas after iodine-125 brachytherapy.

M Würker1, K Herholz, J Voges, U Pietrzyk, H Treuer, B Bauer, V Sturm, W D Heiss.   

Abstract

We investigated whether 2-[18F]-fluoro-2-deoxy-d-glucose (FDG) and carbon-11 methionine are suitable tracers to monitor the effects of therapy for low-grade gliomas. Ten patients with low-grade glioma without previous treatment were studied with FDG positron emission tomography. Additionally, l-[methyl-11C]methionine uptake was measured in five subjects before and 1 year after computerized tomography (CT)-guided stereotactic and computer-assisted implantation of iodine-125 seeds. All scans were 3D-matched to CT, isodose volumes were determined, and changes in glucose metabolism and methionine uptake were evaluated in tumour and brain tissue as a function of radiation dose. After 1 year glucose metabolism was not significantly altered up to a radiation dose of 300 Gy, whereas methionine uptake showed a significant dose-dependent decrease. Higher rates of decline were found in tumours with high basal methionine incorporation activity before therapy. These data suggest that measurement of methionine uptake is more suitable than measurement of FDG uptake for monitoring therapeutic effects in low-grade gliomas.

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Year:  1996        PMID： 8698067     DOI： 10.1007/bf00833397

Source DB:  PubMed          Journal:  Eur J Nucl Med        ISSN： 0340-6997


  10 in total

1.  Changes of cerebral blood flow, and oxygen and glucose metabolism following radiochemotherapy of gliomas: a PET study.

Authors:  T Ogawa; K Uemura; F Shishido; T Yamaguchi; M Murakami; A Inugami; I Kanno; H Sasaki; T Kato; K Hirata
Journal:  J Comput Assist Tomogr       Date:  1988 Mar-Apr       Impact factor: 1.826

2.  Estimation of local cerebral glucose utilization by positron emission tomography of [18F]2-fluoro-2-deoxy-D-glucose: a critical appraisal of optimization procedures.

Authors:  K Wienhard; G Pawlik; K Herholz; R Wagner; W D Heiss
Journal:  J Cereb Blood Flow Metab       Date:  1985-03       Impact factor: 6.200

3.  Computerized optimization of 125I implants in brain tumors.

Authors:  B Bauer-Kirpes; V Sturm; W Schlegel; W J Lorenz
Journal:  Int J Radiat Oncol Biol Phys       Date:  1988-05       Impact factor: 7.038

4.  An interactive technique for three-dimensional image registration: validation for PET, SPECT, MRI and CT brain studies.

Authors:  U Pietrzyk; K Herholz; G Fink; A Jacobs; R Mielke; I Slansky; M Würker; W D Heiss
Journal:  J Nucl Med       Date:  1994-12       Impact factor: 10.057

5.  [11C]L-methionine uptake in gliomas.

Authors:  J M Derlon; C Bourdet; P Bustany; M Chatel; J Theron; F Darcel; A Syrota
Journal:  Neurosurgery       Date:  1989-11       Impact factor: 4.654

6.  Early changes in tumor metabolism after treatment: the effects of stereotactic radiotherapy.

Authors:  J M Rozental; R L Levine; M P Mehta; T J Kinsella; A B Levin; O Algan; M Mendoza; J M Hanson; D A Schrader; R J Nickles
Journal:  Int J Radiat Oncol Biol Phys       Date:  1991-05       Impact factor: 7.038

Review 7.  Amino acids for the measurement of protein synthesis in vivo by PET.

Authors:  W Vaalburg; H H Coenen; C Crouzel; P H Elsinga; B Långström; C Lemaire; G J Meyer
Journal:  Int J Rad Appl Instrum B       Date:  1992-02

8.  Iodine-125 interstitial irradiation of virally induced dog brain tumours.

Authors:  C B Ostertag; P Warnke; P Kleihues; D D Bigner
Journal:  Neurol Res       Date:  1984-12       Impact factor: 2.448

9.  Brain tumor protein synthesis and histological grades: a study by positron emission tomography (PET) with C11-L-Methionine.

Authors:  P Bustany; M Chatel; J M Derlon; F Darcel; P Sgouropoulos; F Soussaline; A Syrota
Journal:  J Neurooncol       Date:  1986       Impact factor: 4.130

10.  Tracer feasibility for monitoring tumor radiotherapy: a quadruple tracer study with fluorine-18-fluorodeoxyglucose or fluorine-18-fluorodeoxyuridine, L-[methyl-14C]methionine, [6-3H]thymidine, and gallium-67.

Authors:  K Kubota; K Ishiwata; R Kubota; S Yamada; M Tada; T Sato; T Ido
Journal:  J Nucl Med       Date:  1991-11       Impact factor: 10.057
  10 in total
  22 in total

Review 1.  Positron emission tomography and the central nervous system.

Authors:  R O Robinson; C D Ferrie; M Capra; M N Maisey
Journal:  Arch Dis Child       Date:  1999-09       Impact factor: 3.791

2.  Evaluation of 11C-methionine PET as a surrogate endpoint after treatment of grade 2 gliomas.

Authors:  Dan Ribom; Marjoleine Schoenmaekers; Henry Engler; Anja Smits
Journal:  J Neurooncol       Date:  2005-02       Impact factor: 4.130

Review 3.  Molecular imaging of gliomas with PET: opportunities and limitations.

Authors:  Christian la Fougère; Bogdana Suchorska; Peter Bartenstein; Friedrich-Wilhelm Kreth; Jörg-Christian Tonn
Journal:  Neuro Oncol       Date:  2011-07-13       Impact factor: 12.300

Review 4.  Molecular imaging of brain tumors: a bridge between clinical and molecular medicine?

Authors:  B J Schaller; M Modo; M Buchfelder
Journal:  Mol Imaging Biol       Date:  2007 Mar-Apr       Impact factor: 3.488

Review 5.  Specific biomarkers of receptors, pathways of inhibition and targeted therapies: clinical applications.

Authors:  Y Waerzeggers; R T Ullrich; P Monfared; T Viel; M Weckesser; W Stummer; O Schober; A Winkeler; A H Jacobs
Journal:  Br J Radiol       Date:  2011-12       Impact factor: 3.039

6.  O-(2-[18F]fluorethyl)-L-tyrosine PET in the clinical evaluation of primary brain tumours.

Authors:  M Weckesser; K J Langen; C H Rickert; S Kloska; R Straeter; K Hamacher; G Kurlemann; H Wassmann; H H Coenen; O Schober
Journal:  Eur J Nucl Med Mol Imaging       Date:  2005-01-14       Impact factor: 9.236

7.  Stereotactic brachytherapy of low-grade cerebral glioma after tumor resection.

Authors:  Bogdana Suchorska; Maximilian Ruge; Harald Treuer; Volker Sturm; Jürgen Voges
Journal:  Neuro Oncol       Date:  2011-08-25       Impact factor: 12.300

8.  Differentiation of glioma and radiation injury in rats using in vitro produce magnetically labeled cytotoxic T-cells and MRI.

Authors:  Ali S Arbab; Branislava Janic; Kourosh Jafari-Khouzani; A S M Iskander; Sanath Kumar; Nadimpalli R S Varma; Robert A Knight; Hamid Soltanian-Zadeh; Stephen L Brown; Joseph A Frank
Journal:  PLoS One       Date:  2010-02-26       Impact factor: 3.240

9.  Diagnostics of cerebral gliomas with radiolabeled amino acids.

Authors:  Karl-Josef Langen; Klaus Tatsch; Anca-Ligia Grosu; Andreas H Jacobs; Matthias Weckesser; Osama Sabri
Journal:  Dtsch Arztebl Int       Date:  2008-01-25       Impact factor: 5.594

10.  Imaging biological activity of a glioblastoma treated with an individual patient-tailored, experimental therapy regimen.

Authors:  N Galldiks; R Ullrich; M Schroeter; G R Fink; L W Kracht
Journal:  J Neurooncol       Date:  2009-01-29       Impact factor: 4.130
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