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Literature DB >> 8678827

Expression of V-SRC and chromosome analysis of a newly established cell line from rat sarcoma induced by an avian retroviral strain.

Abstract

In the newly established rat sarcoma cell line LSR-SF (SR) expression of pp60v-src was detected. Karyotype analyses revealed various chromosome aberrations during prolonged passaging of the tumor cells in vitro. Polyploidy was found to be a characteristic feature of the line studied. A large metacentric chromosome persistently present in the cells was accepted as a line marker.

Entities: CellLine Disease Species

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Year: 1996 PMID： 8678827 DOI： 10.1007/bf01718156

Source DB: PubMed Journal: Arch Virol ISSN： 0304-8608 Impact factor: 2.574

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References

29 in total

1. Identification of a transformation-specific antigen induced by an avian sarcoma virus.

Authors: J S Brugge; R L Erikson
Journal: Nature Date: 1977-09-22 Impact factor: 49.962

2. Characterization of transforming viruses rescued from a hamster tumour cell line harbouring the v-src gene flanked by long terminal repeats.

Authors: J Geryk; J Pichrtova; R V Guntaka; S Gowda; J Svoboda
Journal: J Gen Virol Date: 1986-11 Impact factor: 3.891

3. Proviruses of avian sarcoma virus are terminally redundant, co-extensive with unintegrated linear DNA and integrated at many sites.

Authors: S H Hughes; P R Shank; D H Spector; H J Kung; J M Bishop; H E Varmus; P K Vogt; M L Breitman
Journal: Cell Date: 1978-12 Impact factor: 41.582

4. A mutation in v-src that removes a single conserved residue in the SH-2 domain of pp60v-src restricts transformation in a host-dependent manner.

Authors: M F Verderame; J M Kaplan; H E Varmus
Journal: J Virol Date: 1989-01 Impact factor: 5.103

Expression of V-SRC and chromosome analysis of a newly established cell line from rat sarcoma induced by an avian retroviral strain.

1. Identification of a transformation-specific antigen induced by an avian sarcoma virus.

2. Characterization of transforming viruses rescued from a hamster tumour cell line harbouring the v-src gene flanked by long terminal repeats.

3. Proviruses of avian sarcoma virus are terminally redundant, co-extensive with unintegrated linear DNA and integrated at many sites.

4. A mutation in v-src that removes a single conserved residue in the SH-2 domain of pp60v-src restricts transformation in a host-dependent manner.

5. Structure of viral DNA and RNA in mammalian cells infected with avian sarcoma virus.

6. No apparent nucleotide sequence specificity in cellular DNA juxtaposed to retrovirus proviruses.

7. Metastatic clones selected from an RSV-induced mouse sarcoma share a common marker chromosome.

8. Malignant transformation of early passage rodent cells by a single mutated human oncogene.

9. Host range mutants of v-src: alterations in kinase activity and substrate interactions.

10. Phosphorylation of tyrosine-416 is not required for the transforming properties and kinase activity of pp60v-src.