Literature DB >> 8676523

An African swine fever virus Bc1-2 homolog, 5-HL, suppresses apoptotic cell death.

C L Afonso1, J G Neilan, G F Kutish, D L Rock.   

Abstract

Here, we show that the African swine fever virus 5-HL gene is a highly conserved viral gene and contains all known protein domains associated with Bcl-2 activity, including those involved with dimerization, mediating cell death, and protein-binding functions, and that its protein product, p21, suppresses apoptotic cell death in the mammalian lymphoid cell line FL5.12. Thus, 5-HL is a true functional viral member of the Bcl-2 gene family.

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Year:  1996        PMID： 8676523      PMCID： PMC190433     

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  53 in total

1.  A workbench for multiple alignment construction and analysis.

Authors:  G D Schuler; S F Altschul; D J Lipman
Journal:  Proteins       Date:  1991

2.  Adenovirus E1B 19-kilodalton protein overcomes the cytotoxicity of E1A proteins.

Authors:  E White; R Cipriani; P Sabbatini; A Denton
Journal:  J Virol       Date:  1991-06       Impact factor: 5.103

3.  A tool for multiple sequence alignment.

Authors:  D J Lipman; S F Altschul; J D Kececioglu
Journal:  Proc Natl Acad Sci U S A       Date:  1989-06       Impact factor: 11.205

4.  Cloning of a bcl-2 homologue by interaction with adenovirus E1B 19K.

Authors:  S N Farrow; J H White; I Martinou; T Raven; K T Pun; C J Grinham; J C Martinou; R Brown
Journal:  Nature       Date:  1995-04-20       Impact factor: 49.962

5.  An African swine fever virus gene with similarity to the proto-oncogene bcl-2 and the Epstein-Barr virus gene BHRF1.

Authors:  J G Neilan; Z Lu; C L Afonso; G F Kutish; M D Sussman; D L Rock
Journal:  J Virol       Date:  1993-07       Impact factor: 5.103

6.  Detection of conserved segments in proteins: iterative scanning of sequence databases with alignment blocks.

Authors:  R L Tatusov; S F Altschul; E V Koonin
Journal:  Proc Natl Acad Sci U S A       Date:  1994-12-06       Impact factor: 11.205

7.  bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death.

Authors:  L H Boise; M González-García; C E Postema; L Ding; T Lindsten; L A Turka; X Mao; G Nuñez; C B Thompson
Journal:  Cell       Date:  1993-08-27       Impact factor: 41.582

8.  Bad, a heterodimeric partner for Bcl-XL and Bcl-2, displaces Bax and promotes cell death.

Authors:  E Yang; J Zha; J Jockel; L H Boise; C B Thompson; S J Korsmeyer
Journal:  Cell       Date:  1995-01-27       Impact factor: 41.582

9.  Experimental African swine fever: apoptosis of lymphocytes and virus replication in other cells.

Authors:  J C Gómez-Villamandos; J Hervás; A Méndez; L Carrasco; J Martín de las Mulas; C J Villeda; P J Wilkinson; M A Sierra
Journal:  J Gen Virol       Date:  1995-09       Impact factor: 3.891

10.  A conserved domain in Bak, distinct from BH1 and BH2, mediates cell death and protein binding functions.

Authors:  T Chittenden; C Flemington; A B Houghton; R G Ebb; G J Gallo; B Elangovan; G Chinnadurai; R J Lutz
Journal:  EMBO J       Date:  1995-11-15       Impact factor: 11.598
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  28 in total

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Authors:  D S Bellows; B N Chau; P Lee; Y Lazebnik; W H Burns; J M Hardwick
Journal:  J Virol       Date:  2000-06       Impact factor: 5.103

2.  Adenovirus E3-6.7K maintains calcium homeostasis and prevents apoptosis and arachidonic acid release.

Authors:  Alexander R Moise; Jason R Grant; Timothy Z Vitalis; Wilfred A Jefferies
Journal:  J Virol       Date:  2002-02       Impact factor: 5.103

3.  Regions of the herpes simplex virus type 1 latency-associated transcript that protect cells from apoptosis in vitro and protect neuronal cells in vivo.

Authors:  Maryam Ahmed; Martin Lock; Cathie G Miller; Nigel W Fraser
Journal:  J Virol       Date:  2002-01       Impact factor: 5.103

4.  Bovine herpesvirus 4 BORFE2 protein inhibits Fas- and tumor necrosis factor receptor 1-induced apoptosis and contains death effector domains shared with other gamma-2 herpesviruses.

Authors:  G H Wang; J Bertin; Y Wang; D A Martin; J Wang; K J Tomaselli; R C Armstrong; J I Cohen
Journal:  J Virol       Date:  1997-11       Impact factor: 5.103

5.  The pp38 gene of Marek's disease virus (MDV) is necessary for cytolytic infection of B cells and maintenance of the transformed state but not for cytolytic infection of the feather follicle epithelium and horizontal spread of MDV.

Authors:  I M Gimeno; R L Witter; H D Hunt; S M Reddy; L F Lee; R F Silva
Journal:  J Virol       Date:  2005-04       Impact factor: 5.103

Review 6.  Regulation of apoptosis by viral gene products.

Authors:  J G Teodoro; P E Branton
Journal:  J Virol       Date:  1997-03       Impact factor: 5.103

7.  African swine fever virus multigene family 360 and 530 genes are novel macrophage host range determinants.

Authors:  L Zsak; Z Lu; T G Burrage; J G Neilan; G F Kutish; D M Moore; D L Rock
Journal:  J Virol       Date:  2001-04       Impact factor: 5.103

8.  Novel swine virulence determinant in the left variable region of the African swine fever virus genome.

Authors:  J G Neilan; L Zsak; Z Lu; G F Kutish; C L Afonso; D L Rock
Journal:  J Virol       Date:  2002-04       Impact factor: 5.103

9.  Vaccinia virus infection disarms the mitochondrion-mediated pathway of the apoptotic cascade by modulating the permeability transition pore.

Authors:  S T Wasilenko; A F Meyers; K Vander Helm; M Barry
Journal:  J Virol       Date:  2001-12       Impact factor: 5.103

10.  Modulation of p53 cellular function and cell death by African swine fever virus.

Authors:  Aitor G Granja; María L Nogal; Carolina Hurtado; José Salas; María L Salas; Angel L Carrascosa; Yolanda Revilla
Journal:  J Virol       Date:  2004-07       Impact factor: 5.103
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