Literature DB >> 8389936

An African swine fever virus gene with similarity to the proto-oncogene bcl-2 and the Epstein-Barr virus gene BHRF1.

J G Neilan1, Z Lu, C L Afonso, G F Kutish, M D Sussman, D L Rock.   

Abstract

An open reading frame, LMW5-HL, in the African swine fever virus genome displays a high degree of similarity to the proto-oncogene bcl-2 and, to a lesser degree, the Epstein-Barr virus gene BHRF1. A highly conserved central region is found in all three proteins. LMW5-HL encodes a protein of 18 kDa that is present in infected porcine macrophages at both early and late times postinfection. The similarity of LMW5-HL to bcl-2 and BHRF1 suggests a role for it in cell maintenance during productive or persistent viral infection.

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Year:  1993        PMID： 8389936      PMCID： PMC237812     

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  41 in total

1.  Structure of vaccinia virus early promoters.

Authors:  A J Davison; B Moss
Journal:  J Mol Biol       Date:  1989-12-20       Impact factor: 5.469

2.  A new method for predicting signal sequence cleavage sites.

Authors:  G von Heijne
Journal:  Nucleic Acids Res       Date:  1986-06-11       Impact factor: 16.971

3.  Comparison of lesions in acute and chronic African swine fever.

Authors:  J Moulton; L Coggins
Journal:  Cornell Vet       Date:  1968-07

4.  The epizootiology of African swine fever in Africa.

Authors:  J Parker; W Plowright; M A Pierce
Journal:  Vet Rec       Date:  1969-12-13       Impact factor: 2.695

5.  Acute African swine fever. Proliferative phase in lymphoreticular tissue and the reticuloendothelial system.

Authors:  S Konno; W D Taylor; A H Dardiri
Journal:  Cornell Vet       Date:  1971-01

6.  Liver pathology in African swine fever.

Authors:  S Konno; W D Taylor; W R Hess; W P Heuschele
Journal:  Cornell Vet       Date:  1971-01

7.  Codon preference and its use in identifying protein coding regions in long DNA sequences.

Authors:  R Staden; A D McLachlan
Journal:  Nucleic Acids Res       Date:  1982-01-11       Impact factor: 16.971

8.  An interactive graphics program for comparing and aligning nucleic acid and amino acid sequences.

Authors:  R Staden
Journal:  Nucleic Acids Res       Date:  1982-05-11       Impact factor: 16.971

9.  Two-dimensional analysis of African swine fever virus proteins and proteins induced in infected cells.

Authors:  A Esteves; M I Marques; J V Costa
Journal:  Virology       Date:  1986-07-15       Impact factor: 3.616

10.  DNA sequencing with chain-terminating inhibitors.

Authors:  F Sanger; S Nicklen; A R Coulson
Journal:  Proc Natl Acad Sci U S A       Date:  1977-12       Impact factor: 11.205
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  45 in total

1.  Effect of enforced expression of human bcl-2 on Japanese encephalitis virus-induced apoptosis in cultured cells.

Authors:  C L Liao; Y L Lin; J J Wang; Y L Huang; C T Yeh; S H Ma; L K Chen
Journal:  J Virol       Date:  1997-08       Impact factor: 5.103

2.  Vaccinia virus virulence factor N1L is a novel promising target for antiviral therapeutic intervention.

Authors:  Anton V Cheltsov; Mika Aoyagi; Alexander Aleshin; Eric Chi-Wang Yu; Taylor Gilliland; Dayong Zhai; Andrey A Bobkov; John C Reed; Robert C Liddington; Ruben Abagyan
Journal:  J Med Chem       Date:  2010-05-27       Impact factor: 7.446

3.  The conserved N-terminal BH4 domain of Bcl-2 homologues is essential for inhibition of apoptosis and interaction with CED-4.

Authors:  D C Huang; J M Adams; S Cory
Journal:  EMBO J       Date:  1998-02-16       Impact factor: 11.598

4.  An African swine fever virus Bc1-2 homolog, 5-HL, suppresses apoptotic cell death.

Authors:  C L Afonso; J G Neilan; G F Kutish; D L Rock
Journal:  J Virol       Date:  1996-07       Impact factor: 5.103

Review 5.  Regulation of apoptosis by viral gene products.

Authors:  J G Teodoro; P E Branton
Journal:  J Virol       Date:  1997-03       Impact factor: 5.103

6.  African swine fever virus multigene family 360 and 530 genes are novel macrophage host range determinants.

Authors:  L Zsak; Z Lu; T G Burrage; J G Neilan; G F Kutish; D M Moore; D L Rock
Journal:  J Virol       Date:  2001-04       Impact factor: 5.103

7.  Open reading frame 5 of porcine reproductive and respiratory syndrome virus as a cause of virus-induced apoptosis.

Authors:  P Suárez; M Díaz-Guerra; C Prieto; M Esteban; J M Castro; A Nieto; J Ortín
Journal:  J Virol       Date:  1996-05       Impact factor: 5.103

8.  Inhibition of IL-2R and SLA class II expression on stimulated lymphocytes by a suppressor activity found in homogenates of African swine fever virus infected cultures.

Authors:  A Canals; J Domínquez; J Tomillo; M Babín; F Alonso
Journal:  Arch Virol       Date:  1995       Impact factor: 2.574

9.  Three distinct regions of the murine gammaherpesvirus 68 genome are transcriptionally active in latently infected mice.

Authors:  H W Virgin; R M Presti; X Y Li; C Liu; S H Speck
Journal:  J Virol       Date:  1999-03       Impact factor: 5.103

10.  Functional and structural studies of the vaccinia virus virulence factor N1 reveal a Bcl-2-like anti-apoptotic protein.

Authors:  Samantha Cooray; Mohammad W Bahar; Nicola G A Abrescia; Colin E McVey; Nathan W Bartlett; Ron A-J Chen; David I Stuart; Jonathan M Grimes; Geoffrey L Smith
Journal:  J Gen Virol       Date:  2007-06       Impact factor: 3.891
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