Literature DB >> 11799152

Adenovirus E3-6.7K maintains calcium homeostasis and prevents apoptosis and arachidonic acid release.

Alexander R Moise1, Jason R Grant, Timothy Z Vitalis, Wilfred A Jefferies.   

Abstract

E3-6.7K is a small and hydrophobic membrane glycoprotein encoded by the E3 region of subgroup C adenovirus. Recently, E3-6.7K has been shown to be required for the downregulation of tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) receptors by the adenovirus E3/10.4K and E3/14.5K complex of proteins. We demonstrate here that E3-6.7K has additional protective roles, independent of other virus proteins. In transfected Jurkat T-cell lymphoma cells, E3-6.7K was found to maintain endoplasmic reticulum-Ca(2+) homeostasis and inhibit the induction of apoptosis by thapsigargin. The presence of E3-6.7K also lead to a reduction in the TNF-induced release of arachidonic acid from transfected U937 human histiocytic lymphoma cells. In addition, E3-6.7K protected cells against apoptosis induced through Fas, TNF receptor, and TRAIL receptors. Therefore, E3-6.7K confers a wide range of protective effects against both Ca(2+) flux-induced and death receptor-mediated apoptosis.

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Year:  2002        PMID： 11799152      PMCID： PMC135875          DOI： 10.1128/jvi.76.4.1578-1587.2002

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  105 in total

1.  The adenovirus E3-10.4K/14.5K complex mediates loss of cell surface Fas (CD95) and resistance to Fas-induced apoptosis.

Authors:  J Shisler; C Yang; B Walter; C F Ware; L R Gooding
Journal:  J Virol       Date:  1997-11       Impact factor: 5.103

2.  Forced degradation of Fas inhibits apoptosis in adenovirus-infected cells.

Authors:  A E Tollefson; T W Hermiston; D L Lichtenstein; C F Colle; R A Tripp; T Dimitrov; K Toth; C E Wells; P C Doherty; W S Wold
Journal:  Nature       Date:  1998-04-16       Impact factor: 49.962

3.  The myxoma virus M-T4 gene encodes a novel RDEL-containing protein that is retained within the endoplasmic reticulum and is important for the productive infection of lymphocytes.

Authors:  M Barry; S Hnatiuk; K Mossman; S F Lee; L Boshkov; G McFadden
Journal:  Virology       Date:  1997-12-22       Impact factor: 3.616

4.  Herpes simplex virus type 1 renders infected cells resistant to cytotoxic T-lymphocyte-induced apoptosis.

Authors:  K R Jerome; J F Tait; D M Koelle; L Corey
Journal:  J Virol       Date:  1998-01       Impact factor: 5.103

5.  A third distinct tumor necrosis factor receptor of orthopoxviruses.

Authors:  V N Loparev; J M Parsons; J C Knight; J F Panus; C A Ray; R M Buller; D J Pickup; J J Esposito
Journal:  Proc Natl Acad Sci U S A       Date:  1998-03-31       Impact factor: 11.205

6.  The adenovirus E3/10.4K-14.5K proteins down-modulate the apoptosis receptor Fas/Apo-1 by inducing its internalization.

Authors:  A Elsing; H G Burgert
Journal:  Proc Natl Acad Sci U S A       Date:  1998-08-18       Impact factor: 11.205

7.  The early region 4 orf4 protein of human adenovirus type 5 induces p53-independent cell death by apoptosis.

Authors:  R C Marcellus; J N Lavoie; D Boivin; G C Shore; G Ketner; P E Branton
Journal:  J Virol       Date:  1998-09       Impact factor: 5.103

8.  BiP, a major chaperone protein of the endoplasmic reticulum lumen, plays a direct and important role in the storage of the rapidly exchanging pool of Ca2+.

Authors:  J P Lièvremont; R Rizzuto; L Hendershot; J Meldolesi
Journal:  J Biol Chem       Date:  1997-12-05       Impact factor: 5.157

9.  E4orf4, a novel adenovirus death factor that induces p53-independent apoptosis by a pathway that is not inhibited by zVAD-fmk.

Authors:  J N Lavoie; M Nguyen; R C Marcellus; P E Branton; G C Shore
Journal:  J Cell Biol       Date:  1998-02-09       Impact factor: 10.539

10.  Increased apoptosis arising from increased expression of the Alzheimer's disease-associated presenilin-2 mutation (N141I).

Authors:  S Janicki; M J Monteiro
Journal:  J Cell Biol       Date:  1997-10-20       Impact factor: 10.539
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  12 in total

1.  The adenovirus E3-6.7K protein adopts diverse membrane topologies following posttranslational translocation.

Authors:  Alexander R Moise; Jason R Grant; Roger Lippé; Reinhard Gabathuler; Wilfred A Jefferies
Journal:  J Virol       Date:  2004-01       Impact factor: 5.103

2.  Adenovirus E3-6.7K protein is required in conjunction with the E3-RID protein complex for the internalization and degradation of TRAIL receptor 2.

Authors:  Drew L Lichtenstein; Konstantin Doronin; Karoly Toth; Mohan Kuppuswamy; William S M Wold; Ann E Tollefson
Journal:  J Virol       Date:  2004-11       Impact factor: 5.103

3.  Identification of a novel immunosubversion mechanism mediated by a virologue of the B-lymphocyte receptor TACI.

Authors:  Jason R Grant; Alexander R Moise; Wilfred A Jefferies
Journal:  Clin Vaccine Immunol       Date:  2007-05-30

4.  Molecular Characterization of the Viroporin Function of Foot-and-Mouth Disease Virus Nonstructural Protein 2B.

Authors:  D P Gladue; E Largo; I de la Arada; V M Aguilella; A Alcaraz; J L R Arrondo; L G Holinka; E Brocchi; E Ramirez-Medina; E A Vuono; K A Berggren; C Carrillo; J L Nieva; M V Borca
Journal:  J Virol       Date:  2018-11-12       Impact factor: 5.103

5.  P2Y2 purinergic receptor modulates virus yield, calcium homeostasis, and cell motility in human cytomegalovirus-infected cells.

Authors:  Saisai Chen; Thomas Shenk; Maciej T Nogalski
Journal:  Proc Natl Acad Sci U S A       Date:  2019-09-03       Impact factor: 11.205

6.  Adenovirus RIDbeta subunit contains a tyrosine residue that is critical for RID-mediated receptor internalization and inhibition of Fas- and TRAIL-induced apoptosis.

Authors:  Drew L Lichtenstein; Peter Krajcsi; David J Esteban; Ann E Tollefson; William S M Wold
Journal:  J Virol       Date:  2002-11       Impact factor: 5.103

7.  The Biology of TRAIL and the Role of TRAIL-Based Therapeutics in Infectious Diseases.

Authors:  Brett D Shepard; Andrew D Badley
Journal:  Antiinfect Agents Med Chem       Date:  2009-04-01

8.  Distinct domains in the adenovirus E3 RIDalpha protein are required for degradation of Fas and the epidermal growth factor receptor.

Authors:  Tom A Zanardi; Soonpin Yei; Drew L Lichtenstein; Ann E Tollefson; William S M Wold
Journal:  J Virol       Date:  2003-11       Impact factor: 5.103

9.  Inhibition of apoptosis in Cryptosporidium parvum-infected intestinal epithelial cells is dependent on survivin.

Authors:  Jin Liu; Shinichiro Enomoto; Cheryl A Lancto; Mitchell S Abrahamsen; Mark S Rutherford
Journal:  Infect Immun       Date:  2008-06-02       Impact factor: 3.441

10.  No evidence of a death-like function for species B1 human adenovirus type 3 E3-9K during A549 cell line infection.

Authors:  Kathryn M Frietze; Samuel K Campos; Adriana E Kajon
Journal:  BMC Res Notes       Date:  2012-08-11
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