Literature DB >> 8673100

Genetic analysis of ageing: role of oxidative damage and environmental stresses.

G M Martin1, S N Austad, T E Johnson.   

Abstract

Evolutionary theory predicts substantial interspecific and intraspecific differences in the proximal mechanisms of ageing. Our goal here is to seek evidence for common ('public') mechanisms among diverse organisms amenable to genetic analysis. Oxidative damage is a candidate for such a public mechanism of ageing. Long-lived strains are relatively resistant to different environmental stresses. The extent to which these stresses produce oxidative damage remains to be established.

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Year:  1996        PMID: 8673100     DOI: 10.1038/ng0596-25

Source DB:  PubMed          Journal:  Nat Genet        ISSN: 1061-4036            Impact factor:   38.330


  114 in total

1.  A functional interaction of Ku with Werner exonuclease facilitates digestion of damaged DNA.

Authors:  D K Orren; A Machwe; P Karmakar; J Piotrowski; M P Cooper; V A Bohr
Journal:  Nucleic Acids Res       Date:  2001-05-01       Impact factor: 16.971

2.  A causal link between respiration and senescence in Podospora anserina.

Authors:  E Dufour; J Boulay; V Rincheval; A Sainsard-Chanet
Journal:  Proc Natl Acad Sci U S A       Date:  2000-04-11       Impact factor: 11.205

Review 3.  Cellular and molecular mechanisms of aging and age related diseases.

Authors:  R Ladislas
Journal:  Pathol Oncol Res       Date:  2000       Impact factor: 3.201

4.  EMBO WORKSHOP REPORT: Molecular and cellular gerontology Serpiano, Switzerland, September 18-22, 1999.

Authors:  C Brack; G Lithgow; H Osiewacz; O Toussaint
Journal:  EMBO J       Date:  2000-05-02       Impact factor: 11.598

5.  Quantitative trait loci affecting survival and fertility-related traits in Caenorhabditis elegans show genotype-environment interactions, pleiotropy and epistasis.

Authors:  D R Shook; T E Johnson
Journal:  Genetics       Date:  1999-11       Impact factor: 4.562

6.  Distinct spectra of somatic mutations accumulated with age in mouse heart and small intestine.

Authors:  M E Dollé; W K Snyder; J A Gossen; P H Lohman; J Vijg
Journal:  Proc Natl Acad Sci U S A       Date:  2000-07-18       Impact factor: 11.205

7.  Positive selection of Caenorhabditis elegans mutants with increased stress resistance and longevity.

Authors:  Manuel J Muñoz; Donald L Riddle
Journal:  Genetics       Date:  2003-01       Impact factor: 4.562

Review 8.  Longevity genes in the nematode Caenorhabditis elegans also mediate increased resistance to stress and prevent disease.

Authors:  T E Johnson; S Henderson; S Murakami; E de Castro; S H de Castro; J Cypser; B Rikke; P Tedesco; C Link
Journal:  J Inherit Metab Dis       Date:  2002-05       Impact factor: 4.982

Review 9.  Molecular gerontology.

Authors:  T B L Kirkwood
Journal:  J Inherit Metab Dis       Date:  2002-05       Impact factor: 4.982

10.  Multiple-stress analysis for isolation of Drosophila longevity genes.

Authors:  Horng-Dar Wang; Parsa Kazemi-Esfarjani; Seymour Benzer
Journal:  Proc Natl Acad Sci U S A       Date:  2004-08-12       Impact factor: 11.205

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