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Literature DB >> 10749581

Cellular and molecular mechanisms of aging and age related diseases.

Abstract

This review on aging is focused on those cellular and molecular mechanisms which concern age related pathologies. The central question addressed is the relationship between normal aging and age-related pathologies such as osteoarthritis, cardiovascular diseases, emphysema, malignant tumors and cognitive decline, dementias. The mechanisms recognized as most important in cell and tissue aging are briefly outlined. Emphasis is laid on the importance of post-synthetic modifications of the macromolecules of the extracellular matrix and on cell matrix interactions. Loss of intercellular communication and cell-matrix interactions as a result of receptor decay and receptor uncoupling were recently recognized as key events. Unavoidable poly-pathology at advanced age may be the answer to the above question.

Entities: Disease

Mesh：

Substances：

Year: 2000 PMID： 10749581 DOI： 10.1007/bf03032651

Source DB: PubMed Journal: Pathol Oncol Res ISSN： 1219-4956 Impact factor: 3.201

46 in total

1. The maintenance of the accuracy of protein synthesis and its relevance to ageing.

Authors: L E ORGEL
Journal: Proc Natl Acad Sci U S A Date: 1963-04 Impact factor: 11.205

Review 2. Elastin-elastase-atherosclerosis revisited.

Authors: L Robert; A M Robert; B Jacotot
Journal: Atherosclerosis Date: 1998-10 Impact factor: 5.162

3. The 80-kD fibronectin fragment increases the production of fibronectin and tumour necrosis factor-alpha (TNF-alpha) in cultured mesangial cells.

Authors: M J Lopez-Armada; E Gonzalez; C Gomez-Guerrero; J Egido
Journal: Clin Exp Immunol Date: 1997-02 Impact factor: 4.330

Review 4. Cell death induced in lymphocytes expressing the elastin-laminin receptor by excess agonists: necrosis and apoptosis.

Authors: G Péterszegi; L Robert
Journal: Biomed Pharmacother Date: 1998 Impact factor: 6.529

5. Aging of the vascular wall: serum concentration of elastin peptides and elastase inhibitors in relation to cardiovascular risk factors. The EVA study.

Authors: L Bizbiz; A Alpérovitch; L Robert
Journal: Atherosclerosis Date: 1997-05 Impact factor: 5.162

6. Cell death by overload of the elastin-laminin receptor on human activated lymphocytes: protection by lactose and melibiose.

Authors: G Péterszegi; S Texier; L Robert
Journal: Eur J Clin Invest Date: 1999-02 Impact factor: 4.686

7. Altered phosphatidylinositol breakdown after K-elastin stimulation in PMNLs of elderly.

Authors: Z Varga; M P Jacob; J Csongor; L Robert; A Leövey; T Fülöp
Journal: Mech Ageing Dev Date: 1990-03-01 Impact factor: 5.432

8. High concentrations of fibronectin fragments cause short-term catabolic effects in cartilage tissue while lower concentrations cause continuous anabolic effects.

Authors: G A Homandberg; F Hui
Journal: Arch Biochem Biophys Date: 1994-06 Impact factor: 4.013

9. Human helper and memory lymphocytes exhibit an inducible elastin-laminin receptor.

Authors: G Péterszegi; S Texier; L Robert
Journal: Int Arch Allergy Immunol Date: 1997-11 Impact factor: 2.749

Review 10. Cancer and aging.

Authors: A Macieira-Coelho
Journal: Exp Gerontol Date: 1986 Impact factor: 4.032

7 in total

Review 1. The Oxygen Paradox, the French Paradox, and age-related diseases.

Authors: Joanna M S Davies; Josiane Cillard; Bertrand Friguet; Enrique Cadenas; Jean Cadet; Rachael Cayce; Andrew Fishmann; David Liao; Anne-Laure Bulteau; Frédéric Derbré; Amélie Rébillard; Steven Burstein; Etienne Hirsch; Robert A Kloner; Michael Jakowec; Giselle Petzinger; Delphine Sauce; Florian Sennlaub; Isabelle Limon; Fulvio Ursini; Matilde Maiorino; Christina Economides; Christian J Pike; Pinchas Cohen; Anne Negre Salvayre; Matthew R Halliday; Adam J Lundquist; Nicolaus A Jakowec; Fatima Mechta-Grigoriou; Mathias Mericskay; Jean Mariani; Zhenlin Li; David Huang; Ellsworth Grant; Henry J Forman; Caleb E Finch; Patrick Y Sun; Laura C D Pomatto; Onnik Agbulut; David Warburton; Christian Neri; Mustapha Rouis; Pierre Cillard; Jacqueline Capeau; Jean Rosenbaum; Kelvin J A Davies
Journal: Geroscience Date: 2017-12-21 Impact factor: 7.713

Cellular and molecular mechanisms of aging and age related diseases.

1. The maintenance of the accuracy of protein synthesis and its relevance to ageing.

Review 2. Elastin-elastase-atherosclerosis revisited.

3. The 80-kD fibronectin fragment increases the production of fibronectin and tumour necrosis factor-alpha (TNF-alpha) in cultured mesangial cells.

Review 4. Cell death induced in lymphocytes expressing the elastin-laminin receptor by excess agonists: necrosis and apoptosis.

5. Aging of the vascular wall: serum concentration of elastin peptides and elastase inhibitors in relation to cardiovascular risk factors. The EVA study.

6. Cell death by overload of the elastin-laminin receptor on human activated lymphocytes: protection by lactose and melibiose.

7. Altered phosphatidylinositol breakdown after K-elastin stimulation in PMNLs of elderly.

8. High concentrations of fibronectin fragments cause short-term catabolic effects in cartilage tissue while lower concentrations cause continuous anabolic effects.

9. Human helper and memory lymphocytes exhibit an inducible elastin-laminin receptor.

Review 10. Cancer and aging.

Review 1. The Oxygen Paradox, the French Paradox, and age-related diseases.

Review 2. Sickle cell disease as an accelerated aging syndrome.

3. Ageing and its implications.

4. Study on the dynamics of cortisol secretions in hypertensive elderly patients.

5. Effect of aging on airway remodeling and muscarinic receptors in a murine acute asthma model.

6. Relationship between perceived sleep and polysomnography in older adult patients.

7. Unacylated ghrelin rescues endothelial progenitor cell function in individuals with type 2 diabetes.