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Literature DB >> 8671315

Incidence of chromosome 21 disomy in human spermatozoa as determined by fluorescent in-situ hybridization.

Abstract

We have evaluated the incidence of chromosome 21 disomy in decondensed sperm heads from nine normal men using a locus-specific DNA probe for chromosome 21, and a centromeric probe for chromosome 6 as a control. The results show that the incidence of chromosome 21 disomy (0.38%) is significantly higher than disomy for chromosome 6(0.14%). No differences were found among the individuals analysed.

Entities: Disease Species

Mesh：

Year: 1996 PMID： 8671315 DOI： 10.1093/oxfordjournals.humrep.a019241

Source DB: PubMed Journal: Hum Reprod ISSN： 0268-1161 Impact factor: 6.918

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Cited

13 in total

1. Sequential FISH allows the determination of the segregation outcome and the presence of numerical anomalies in spermatozoa from a t(1;8;2)(q42;p21;p15) carrier.

Authors: Anna Godo; Joan Blanco; Francesca Vidal; Mònica Parriego; Montserrat Boada; Ester Anton
Journal: J Assist Reprod Genet Date: 2013-08-23 Impact factor: 3.412

2. Chromosome 21 disomy in the spermatozoa of the fathers of children with trisomy 21, in a population with a high prevalence of Down syndrome: increased incidence in cases of paternal origin.

Authors: J Blanco; E Gabau; D Gómez; N Baena; M Guitart; J Egozcue; F Vidal
Journal: Am J Hum Genet Date: 1998-10 Impact factor: 11.025

3. Fluorescence in situ hybridization with chromosome paint probes: a novel approach to assess aneuploidy in human sperm nuclei.

Authors: N Rives; S Wust; B David; V Duchesne; G Joly; B Mace
Journal: J Assist Reprod Genet Date: 1999-01 Impact factor: 3.412

4. Genetics of human sperm.

Authors: R H Martin
Journal: J Assist Reprod Genet Date: 1998-05 Impact factor: 3.412

5. Sex chromosomal analysis of spermatozoa from infertile men using fluorescence in situ hybridization.

Authors: N Nishikawa; I Murakami; K Ikuta; K Suzumori
Journal: J Assist Reprod Genet Date: 2000-02 Impact factor: 3.412

6. Preliminary analysis of numerical chromosome abnormalities in reciprocal and Robertsonian translocation preimplantation genetic diagnosis cases with 24-chromosomal analysis with an aCGH/SNP microarray.

Authors: Yanxin Xie; Yanwen Xu; Jing Wang; Benyu Miao; Yanhong Zeng; Chenhui Ding; Jun Gao; Canquan Zhou
Journal: J Assist Reprod Genet Date: 2017-09-18 Impact factor: 3.412

Incidence of chromosome 21 disomy in human spermatozoa as determined by fluorescent in-situ hybridization.

1. Sequential FISH allows the determination of the segregation outcome and the presence of numerical anomalies in spermatozoa from a t(1;8;2)(q42;p21;p15) carrier.

2. Chromosome 21 disomy in the spermatozoa of the fathers of children with trisomy 21, in a population with a high prevalence of Down syndrome: increased incidence in cases of paternal origin.

3. Fluorescence in situ hybridization with chromosome paint probes: a novel approach to assess aneuploidy in human sperm nuclei.

4. Genetics of human sperm.

5. Sex chromosomal analysis of spermatozoa from infertile men using fluorescence in situ hybridization.

6. Preliminary analysis of numerical chromosome abnormalities in reciprocal and Robertsonian translocation preimplantation genetic diagnosis cases with 24-chromosomal analysis with an aCGH/SNP microarray.

7. Implications of sperm chromosome abnormalities in recurrent miscarriage.

8. The use of fluorescent in situ hybridization in male infertility.

9. Frequency of XY sperm increases with age in fathers of boys with Klinefelter syndrome.

10. High sex chromosome aneuploidy and diploidy rate of epididymal spermatozoa in obstructive azoospermic men.