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Literature DB >> 8662506

Polar overdominance at the ovine callipyge locus.

N E Cockett¹, S P Jackson, T L Shay, F Farnir, S Berghmans, G D Snowder, D M Nielsen, M Georges.

Abstract

An inheritable muscular hypertrophy was recently described in sheep and shown to be determined by the callipyge gene mapped to ovine chromosome 18. Here, the callipyge phenotype was found to be characterized by a nonmendelian inheritance pattern, referred to as polar overdominance, where only heterozygous individuals having inherited the callipyge mutation from their sire express the phenotype. The possible role of parental imprinting in the determinism of polar overdominance is envisaged.

Entities: Disease Species

Mesh：

Year: 1996 PMID： 8662506 DOI： 10.1126/science.273.5272.236

Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728

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Cited

60 in total

1. Novel imprinted DLK1/GTL2 domain on human chromosome 14 contains motifs that mimic those implicated in IGF2/H19 regulation.

Authors: A A Wylie; S K Murphy; T C Orton; R L Jirtle
Journal: Genome Res Date: 2000-11 Impact factor: 9.043

2. Genomic imprinting and position-effect variegation in Drosophila melanogaster.

Authors: V K Lloyd; D A Sinclair; T A Grigliatti
Journal: Genetics Date: 1999-04 Impact factor: 4.562

3. Mosaicism of Solid Gold supports the causality of a noncoding A-to-G transition in the determinism of the callipyge phenotype.

Authors: Maria Smit; Karin Segers; Laura Garcia Carrascosa; Tracy Shay; Francesca Baraldi; Gabor Gyapay; Gary Snowder; Michel Georges; Noelle Cockett; Carole Charlier
Journal: Genetics Date: 2003-01 Impact factor: 4.562

4. Identification of the single base change causing the callipyge muscle hypertrophy phenotype, the only known example of polar overdominance in mammals.

Authors: Brad A Freking; Susan K Murphy; Andrew A Wylie; Simon J Rhodes; John W Keele; Kreg A Leymaster; Randy L Jirtle; Timothy P L Smith
Journal: Genome Res Date: 2002-10 Impact factor: 9.043

5. Assessing the effect of the CLPG mutation on the microRNA catalog of skeletal muscle using high-throughput sequencing.

Authors: Florian Caiment; Carole Charlier; Tracy Hadfield; Noelle Cockett; Michel Georges; Denis Baurain
Journal: Genome Res Date: 2010-10-13 Impact factor: 9.043

6. BEGAIN: a novel imprinted gene that generates paternally expressed transcripts in a tissue- and promoter-specific manner in sheep.

Authors: Maria A Smit; Xavier Tordoir; Gabor Gyapay; Noelle E Cockett; Michel Georges; Carole Charlier
Journal: Mamm Genome Date: 2005-10-29 Impact factor: 2.957

Polar overdominance at the ovine callipyge locus.

1. Novel imprinted DLK1/GTL2 domain on human chromosome 14 contains motifs that mimic those implicated in IGF2/H19 regulation.

2. Genomic imprinting and position-effect variegation in Drosophila melanogaster.

3. Mosaicism of Solid Gold supports the causality of a noncoding A-to-G transition in the determinism of the callipyge phenotype.

4. Identification of the single base change causing the callipyge muscle hypertrophy phenotype, the only known example of polar overdominance in mammals.

5. Assessing the effect of the CLPG mutation on the microRNA catalog of skeletal muscle using high-throughput sequencing.

6. BEGAIN: a novel imprinted gene that generates paternally expressed transcripts in a tissue- and promoter-specific manner in sheep.

7. Callipyge mutation affects gene expression in cis: a potential role for chromatin structure.

8. The callipyge mutation enhances bidirectional long-range DLK1-GTL2 intergenic transcription in cis.

9. Maternal effects as the cause of parent-of-origin effects that mimic genomic imprinting.

10. On the detection of imprinted quantitative trait loci in line crosses: effect of linkage disequilibrium.