Literature DB >> 1980485

Manic depressive illness not linked to factor IX region in an independent series of pedigrees.

P V Gejman1, S Detera-Wadleigh, M M Martinez, W H Berrettini, L R Goldin, J Gelernter, W T Hsieh, E S Gershon.   

Abstract

We studied seven informative kindreds segregating for manic depressive illness (MDI), consistent with X-chromosome transmission of the trait (families do not show affective disease in both a father and a son), using markers mapped to the region of Xq27-Xq28. The lod scores were consistently below -2 in the region extending from about 10 cM centromeric from the Factor IX locus (F9) to the colorblindness region. This study does not replicate previous reports of linkage of MDI to Factor IX (Xq27) and colorblindness region (Xq28) chromosomal markers in other kindreds.

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Year:  1990        PMID： 1980485     DOI： 10.1016/0888-7543(90)90251-o

Source DB:  PubMed          Journal:  Genomics        ISSN： 0888-7543            Impact factor:   5.736


  2 in total

1.  A critical analysis of data presented in eight studies favouring X-linkage of bipolar illness with special emphasis on formal genetic aspects.

Authors:  J Hebebrand; K Hennighausen
Journal:  Hum Genet       Date:  1992-11       Impact factor: 4.132

2.  Affected-sib-pair analyses reveal support of prior evidence for a susceptibility locus for bipolar disorder, on 21q.

Authors:  S D Detera-Wadleigh; J A Badner; L R Goldin; W H Berrettini; A R Sanders; D Y Rollins; G Turner; T Moses; H Haerian; D Muniec; J I Nurnberger; E S Gershon
Journal:  Am J Hum Genet       Date:  1996-06       Impact factor: 11.025
  2 in total

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