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Literature DB >> 8649418

Interaction of Vav with ENX-1, a putative transcriptional regulator of homeobox gene expression.

Abstract

The proto-oncogene product Vav plays a critical role in hematopoietic signal transduction. By using the yeast two-hybrid system, we identified a novel human protein, ENX-1, which interacts specifically with Vav both in vitro and in vivo. ENX-1 represents the human homolog of the Drosophila Enhancer of zeste gene, a member of the Polycomb group of genes, which are transcriptional regulators of homeobox gene expression. Interaction with ENX-1 suggests that Vav functions as an upstream element in the transcriptional regulation of homeobox genes, known to be important effectors in the hematopoietic system.

Entities: Gene Species

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Year: 1996 PMID： 8649418 PMCID： PMC231301 DOI： 10.1128/MCB.16.6.3066

Source DB: PubMed Journal: Mol Cell Biol ISSN： 0270-7306 Impact factor: 4.272

41 in total

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Authors: J Simon
Journal: Curr Opin Cell Biol Date: 1995-06 Impact factor: 8.382

Review 2. The two-hybrid system: an assay for protein-protein interactions.

Authors: S Fields; R Sternglanz
Journal: Trends Genet Date: 1994-08 Impact factor: 11.639

Review 3. The LIM domain: a new structural motif found in zinc-finger-like proteins.

Authors: I Sánchez-García; T H Rabbitts
Journal: Trends Genet Date: 1994-09 Impact factor: 11.639

4. Binding of Vav to Grb2 through dimerization of Src homology 3 domains.

Authors: Z S Ye; D Baltimore
Journal: Proc Natl Acad Sci U S A Date: 1994-12-20 Impact factor: 11.205

5. Defective antigen receptor-mediated proliferation of B and T cells in the absence of Vav.

Authors: A Tarakhovsky; M Turner; S Schaal; P J Mee; L P Duddy; K Rajewsky; V L Tybulewicz
Journal: Nature Date: 1995-03-30 Impact factor: 49.962

6. Novel signaling pathway suggested by SH3 domain-mediated p95vav/heterogeneous ribonucleoprotein K interaction.

Authors: O Hobert; B Jallal; J Schlessinger; A Ullrich
Journal: J Biol Chem Date: 1994-08-12 Impact factor: 5.157

7. Posterior transformation, neurological abnormalities, and severe hematopoietic defects in mice with a targeted deletion of the bmi-1 proto-oncogene.

Authors: N M van der Lugt; J Domen; K Linders; M van Roon; E Robanus-Maandag; H te Riele; M van der Valk; J Deschamps; M Sofroniew; M van Lohuizen
Journal: Genes Dev Date: 1994-04-01 Impact factor: 11.361

8. The LIM protein RBTN2 and the basic helix-loop-helix protein TAL1 are present in a complex in erythroid cells.

Authors: V E Valge-Archer; H Osada; A J Warren; A Forster; J Li; R Baer; T H Rabbitts
Journal: Proc Natl Acad Sci U S A Date: 1994-08-30 Impact factor: 11.205

9. Association of the vav proto-oncogene product with poly(rC)-specific RNA-binding proteins.

Authors: X R Bustelo; K L Suen; W M Michael; G Dreyfuss; M Barbacid
Journal: Mol Cell Biol Date: 1995-03 Impact factor: 4.272

10. The protein encoded by the Drosophila position-effect variegation suppressor gene Su(var)3-9 combines domains of antagonistic regulators of homeotic gene complexes.

Authors: B Tschiersch; A Hofmann; V Krauss; R Dorn; G Korge; G Reuter
Journal: EMBO J Date: 1994-08-15 Impact factor: 11.598

36 in total

1. Vav1 oncogenic mutation inhibits T cell receptor-induced calcium mobilization through inhibition of phospholipase Cγ1 activation.

Authors: Mira Knyazhitsky; Etay Moas; Ekaterina Shaginov; Anna Luria; Alex Braiman
Journal: J Biol Chem Date: 2012-04-03 Impact factor: 5.157

2. Interaction of mouse polycomb-group (Pc-G) proteins Enx1 and Enx2 with Eed: indication for separate Pc-G complexes.

Authors: M van Lohuizen; M Tijms; J W Voncken; A Schumacher; T Magnuson; E Wientjens
Journal: Mol Cell Biol Date: 1998-06 Impact factor: 4.272

3. Characterization of interactions between the mammalian polycomb-group proteins Enx1/EZH2 and EED suggests the existence of different mammalian polycomb-group protein complexes.

Authors: R G Sewalt; J van der Vlag; M J Gunster; K M Hamer; J L den Blaauwen; D P Satijn; T Hendrix; R van Driel; A P Otte
Journal: Mol Cell Biol Date: 1998-06 Impact factor: 4.272

Review 4. T-cell identity and epigenetic memory.

Authors: Ellen V Rothenberg; Jingli A Zhang
Journal: Curr Top Microbiol Immunol Date: 2012 Impact factor: 4.291

5. The methyltransferase Ezh2 controls cell adhesion and migration through direct methylation of the extranuclear regulatory protein talin.

Authors: Merry Gunawan; Nandini Venkatesan; Jia Tong Loh; Jong Fu Wong; Heidi Berger; Wen Hao Neo; Liang Yao Jackson Li; Myint Khun La Win; Yin Hoe Yau; Tiannan Guo; Peter Chi Ee See; Sayuri Yamazaki; Keh Chuang Chin; Alexandre R Gingras; Susana Geifman Shochat; Lai Guan Ng; Siu Kwan Sze; Florent Ginhoux; I-hsin Su
Journal: Nat Immunol Date: 2015-03-09 Impact factor: 25.606

10. JNK and STAT3 signaling pathways converge on Akt-mediated phosphorylation of EZH2 in bronchial epithelial cells induced by arsenic.

Authors: Bailing Chen; Jia Liu; Qingshan Chang; Kevin Beezhold; Yongju Lu; Fei Chen
Journal: Cell Cycle Date: 2012-12-19 Impact factor: 4.534