Literature DB >> 864125

Active site generated analogues of reactive intermediates in enzymic reactions. Potent inhibition of pyruvate dehydrogenase by a phosphonate analogue of pyruvate1.

R Kluger, D C Pike.   

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Year:  1977        PMID： 864125     DOI： 10.1021/ja00455a052

Source DB:  PubMed          Journal:  J Am Chem Soc        ISSN： 0002-7863            Impact factor:   15.419


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  20 in total

1.  Challenges and Hallmarks of Establishing Alkylacetylphosphonates as Probes of Bacterial 1-Deoxy-d-xylulose 5-Phosphate Synthase.

Authors:  Sara Sanders; Ryan J Vierling; David Bartee; Alicia A DeColli; Mackenzie J Harrison; Joseph L Aklinski; Andrew T Koppisch; Caren L Freel Meyers
Journal:  ACS Infect Dis       Date:  2017-06-21       Impact factor: 5.084

2.  The preparation and properties of bromoacetylphosphonic acid.

Authors:  M J Sparkes; H B Dixon
Journal:  Biochem J       Date:  1991-05-01       Impact factor: 3.857

3.  X-ray crystallography-based structural elucidation of enzyme-bound intermediates along the 1-deoxy-d-xylulose 5-phosphate synthase reaction coordinate.

Authors:  Percival Yang-Ting Chen; Alicia A DeColli; Caren L Freel Meyers; Catherine L Drennan
Journal:  J Biol Chem       Date:  2019-06-25       Impact factor: 5.157

4.  Characterization and structure of DhpI, a phosphonate O-methyltransferase involved in dehydrophos biosynthesis.

Authors:  Jin-Hee Lee; Brian Bae; Michael Kuemin; Benjamin T Circello; William W Metcalf; Satish K Nair; Wilfred A van der Donk
Journal:  Proc Natl Acad Sci U S A       Date:  2010-09-27       Impact factor: 11.205

5.  Covalently bound substrate at the regulatory site of yeast pyruvate decarboxylases triggers allosteric enzyme activation.

Authors:  Steffen Kutter; Manfred S Weiss; Georg Wille; Ralph Golbik; Michael Spinka; Stephan König
Journal:  J Biol Chem       Date:  2009-02-26       Impact factor: 5.157

6.  Conformational ensemble modulates cooperativity in the rate-determining catalytic step in the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex.

Authors:  Sachin Kale; Frank Jordan
Journal:  J Biol Chem       Date:  2009-09-29       Impact factor: 5.157

7.  Glyoxylate carboligase: a unique thiamin diphosphate-dependent enzyme that can cycle between the 4'-aminopyrimidinium and 1',4'-iminopyrimidine tautomeric forms in the absence of the conserved glutamate.

Authors:  Natalia Nemeria; Elad Binshtein; Hetalben Patel; Anand Balakrishnan; Ilan Vered; Boaz Shaanan; Ze'ev Barak; David Chipman; Frank Jordan
Journal:  Biochemistry       Date:  2012-09-25       Impact factor: 3.162

8.  Metabolism of 1-aminoethylphosphinate generates acetylphosphinate, a potent inhibitor of pyruvate dehydrogenase.

Authors:  B Laber; N Amrhein
Journal:  Biochem J       Date:  1987-12-01       Impact factor: 3.857

9.  Observation of a stable carbene at the active site of a thiamin enzyme.

Authors:  Danilo Meyer; Piotr Neumann; Ralf Ficner; Kai Tittmann
Journal:  Nat Chem Biol       Date:  2013-06-09       Impact factor: 15.040

10.  Human 2-oxoglutarate dehydrogenase complex E1 component forms a thiamin-derived radical by aerobic oxidation of the enamine intermediate.

Authors:  Natalia S Nemeria; Attila Ambrus; Hetalben Patel; Gary Gerfen; Vera Adam-Vizi; Laszlo Tretter; Jieyu Zhou; Junjie Wang; Frank Jordan
Journal:  J Biol Chem       Date:  2014-09-10       Impact factor: 5.157
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