Literature DB >> 2039453

The preparation and properties of bromoacetylphosphonic acid.

M J Sparkes1, H B Dixon.   

Abstract

Bromoacetylphosphonic acid, Br-CH2-CO-PO3H2, was made by brominating dimethyl acetylphosphonate and de-esterifying with HBr. It proves to be a powerful alkylating agent, reacting rapidly with GSH, with a rate constant of about 6M(-1).s(-1) at pH6.

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Year:  1991        PMID： 2039453      PMCID： PMC1150120          DOI： 10.1042/bj2750772

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  5 in total

1.  Detection of phosphate esters on paper chromatograms.

Authors:  H E WADE; D M MORGAN
Journal:  Nature       Date:  1953-03-21       Impact factor: 49.962

2.  Spin-label study of the mobility of enzyme-bound lipoic acid in the pyruvate dehydrogenase multienzyme complex of Escherichia coli.

Authors:  M C Ambrose; R N Perham
Journal:  Biochem J       Date:  1976-05-01       Impact factor: 3.857

3.  Active site generated analogues of reactive intermediates in enzymic reactions. Potent inhibition of pyruvate dehydrogenase by a phosphonate analogue of pyruvate1.

Authors:  R Kluger; D C Pike
Journal:  J Am Chem Soc       Date:  1977-06-22       Impact factor: 15.419

4.  Use of methyl iodide for probing the polarity of the immediate environment of --SH groups in thiolenzymes. Reaction of methyl iodide with thiosubtilisin.

Authors:  P Halász; L Polgár
Journal:  Eur J Biochem       Date:  1976-12-11

5.  Phosphonomethyl analogues of phosphate ester glycolytic intermediates.

Authors:  H B Dixon; M J Sparkes
Journal:  Biochem J       Date:  1974-09       Impact factor: 3.857
  5 in total
  1 in total

1.  Alkylation of glyceraldehyde-3-phosphate dehydrogenase with haloacetylphosphonates. An unusual pH-dependence.

Authors:  Y K Li; J Boggaram; L D Byers
Journal:  Biochem J       Date:  1991-05-01       Impact factor: 3.857
  1 in total

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