Literature DB >> 8633060

Purified inositol hexakisphosphate kinase is an ATP synthase: diphosphoinositol pentakisphosphate as a high-energy phosphate donor.

S M Voglmaier1, M E Bembenek, A I Kaplin, G Dormán, J D Olszewski, G D Prestwich, S H Snyder.   

Abstract

Diphosphoinositol pentakisphosphate (PP-IP5) and bis(diphospho)inositol tetrakisphosphate (bis-PP-IP4) are recently identified inositol phosphates that possess pyrophosphate bonds. We have purified an inositol hexakisphosphate (IP6) kinase from rat brain supernatants. The pure protein, a monomer of 54 kDa, displays high affinity (Km = 0.7 microM) and selectivity for inositol hexakisphosphate as substrate. It can be dissociated from bis(diphospho)inositol tetrakisphosphate synthetic activity. The purified enzyme transfers a phosphate from PP-IP5 to ADP to form ATP. This ATP synthase activity indicates the high phosphate group transfer potential of PP-IP5 and may represent a physiological role for PP-IP5.

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Year:  1996        PMID： 8633060      PMCID： PMC39531          DOI： 10.1073/pnas.93.9.4305

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  51 in total

1.  A COMPLETE INTRACELLULAR UNIT FOR INCORPORATION OF AMINO-ACID INTO STORAGE PROTEIN UTILIZING ADENOSINE TRIPHOSPHATE GENERATED FROM PHYTATE.

Authors:  R K MORTON; J K RAISON
Journal:  Nature       Date:  1963-11-02       Impact factor: 49.962

2.  Catalytic properties of inositol trisphosphate kinase: activation by Ca2+ and calmodulin.

Authors:  S H Ryu; S Y Lee; K Y Lee; S G Rhee
Journal:  FASEB J       Date:  1987-11       Impact factor: 5.191

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Authors:  J K Raison; W J Evans
Journal:  Biochim Biophys Acta       Date:  1968-12-23

4.  Cleavage of structural proteins during the assembly of the head of bacteriophage T4.

Authors:  U K Laemmli
Journal:  Nature       Date:  1970-08-15       Impact factor: 49.962

5.  Purification and characterization of myo-inositol hexaphosphate-adenosine diphosphate phosphotransferase from Phaseolus aureus.

Authors:  S Biswas; I B Maity; S Chakrabarti; B B Biswas
Journal:  Arch Biochem Biophys       Date:  1978-01-30       Impact factor: 4.013

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Journal:  J Biol Chem       Date:  1979-07-25       Impact factor: 5.157

7.  Phytic acid. A natural antioxidant.

Authors:  E Graf; K L Empson; J W Eaton
Journal:  J Biol Chem       Date:  1987-08-25       Impact factor: 5.157

8.  A possible docking and fusion particle for synaptic transmission.

Authors:  G Schiavo; M J Gmachl; G Stenbeck; T H Söllner; J E Rothman
Journal:  Nature       Date:  1995-12-14       Impact factor: 49.962

9.  Observation of inositol pentakis- and hexakis-phosphates in mammalian tissues by 31P NMR.

Authors:  B S Szwergold; R A Graham; T R Brown
Journal:  Biochem Biophys Res Commun       Date:  1987-12-31       Impact factor: 3.575

10.  Purification of D-myo-inositol 1,4,5-trisphosphate 3-kinase from rat brain.

Authors:  R A Johanson; C A Hansen; J R Williamson
Journal:  J Biol Chem       Date:  1988-06-05       Impact factor: 5.157
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  54 in total

Review 1.  How versatile are inositol phosphate kinases?

Authors:  Stephen B Shears
Journal:  Biochem J       Date:  2004-01-15       Impact factor: 3.857

Review 2.  Diphosphoinositol polyphosphates: what are the mechanisms?

Authors:  Stephen B Shears; Nikhil A Gokhale; Huanchen Wang; Angelika Zaremba
Journal:  Adv Enzyme Regul       Date:  2010-10-28

3.  Neuronal migration is mediated by inositol hexakisphosphate kinase 1 via α-actinin and focal adhesion kinase.

Authors:  Chenglai Fu; Jing Xu; Weiwei Cheng; Tomas Rojas; Alfred C Chin; Adele M Snowman; Maged M Harraz; Solomon H Snyder
Journal:  Proc Natl Acad Sci U S A       Date:  2017-02-02       Impact factor: 11.205

4.  Conformational changes in inositol 1,3,4,5,6-pentakisphosphate 2-kinase upon substrate binding: role of N-terminal lobe and enantiomeric substrate preference.

Authors:  José Ignacio Baños-Sanz; Julia Sanz-Aparicio; Hayley Whitfield; Chris Hamilton; Charles A Brearley; Beatriz González
Journal:  J Biol Chem       Date:  2012-06-28       Impact factor: 5.157

5.  Inositol polyphosphates intersect with signaling and metabolic networks via two distinct mechanisms.

Authors:  Mingxuan Wu; Lucy S Chong; David H Perlman; Adam C Resnick; Dorothea Fiedler
Journal:  Proc Natl Acad Sci U S A       Date:  2016-10-19       Impact factor: 11.205

6.  A novel context for the 'MutT' module, a guardian of cell integrity, in a diphosphoinositol polyphosphate phosphohydrolase.

Authors:  S T Safrany; J J Caffrey; X Yang; M E Bembenek; M B Moyer; W A Burkhart; S B Shears
Journal:  EMBO J       Date:  1998-11-16       Impact factor: 11.598

7.  Simulations of inositol phosphate metabolism and its interaction with InsP(3)-mediated calcium release.

Authors:  Jyoti Mishra; Upinder S Bhalla
Journal:  Biophys J       Date:  2002-09       Impact factor: 4.033

8.  Inositol pyrophosphates and their unique metabolic complexity: analysis by gel electrophoresis.

Authors:  Oriana Losito; Zsolt Szijgyarto; Adam Cain Resnick; Adolfo Saiardi
Journal:  PLoS One       Date:  2009-05-18       Impact factor: 3.240

9.  Cellular Cations Control Conformational Switching of Inositol Pyrophosphate Analogues.

Authors:  Anastasia Hager; Mingxuan Wu; Huanchen Wang; Nathaniel W Brown; Stephen B Shears; Nicolás Veiga; Dorothea Fiedler
Journal:  Chemistry       Date:  2016-07-27       Impact factor: 5.236

Review 10.  Inositol pyrophosphates: structure, enzymology and function.

Authors:  Christopher John Barker; Christopher Illies; Gian Carlo Gaboardi; Per-Olof Berggren
Journal:  Cell Mol Life Sci       Date:  2009-08-28       Impact factor: 9.261
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